Results 101 to 110 of about 1,491,850 (243)

Alterations in step frequency and muscle activities using body weight support influence the ventilatory response to sinusoidal walking in humans. [PDF]

Sci Rep, 2023
Fujita M, Kamibayashi K, Horiuchi M, Ebine N, Fukuoka Y.   +4 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Sensor Integration Alters Biomechanical Load Transfer in Pressure Mapping of Neonatal Support Surfaces

Advances in Materials Science and Engineering
In bedridden patients, the constant load between the body and the support surface increases the risk of soft tissue injuries. Understanding body–mattress interactions is the key to developing pressure-reducing support surfaces.
Tino A. Jucker, Simon Annaheim, Martin Camenzind, René M. Rossi   +3 more
doaj   +1 more source

Effect of Robotic-Assisted Gait at Different Levels of Guidance and Body Weight Support on Lower Limb Joint Kinematics and Coordination. [PDF]

Sensors (Basel), 2023
Cherni Y, Blache Y, Begon M, Ballaz L, Dal Maso F.   +4 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Treadmill walking with body weight support

, 2012
Background: Rehabilitating walking in patients post-stroke with safe, task-specific, intensive training of sufficient duration, can be challenging. Body weight supported treadmill training (BWSTT) has been proposed as an effective method to meet these challenges and may therefore have benefits over training overground walking.
openaire   +1 more source

A novel Dynamic Body Weight Support overground co-walker enabling variable unloading ratio and Motion Tracking. [PDF]

Front Neurosci, 2023
Zhang X, Shang P, Li B.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Effects of dynamic body weight support on functional independence measures in acute ischemic stroke: a retrospective cohort study. [PDF]

J Neuroeng Rehabil, 2023
Huber J, Elwert N, Powell ES, Westgate PM, Hines E, Sawaki L.   +5 more
europepmc   +1 more source