Results 141 to 150 of about 626,901 (398)

Improving the understandability of the next edition of the International System of Units (SI) by focusing on its conceptual structure

open access: yes, 2017
The International System of Units (SI) is fundamental for the social, and not only the scientific, role of metrology, and as such its understandability is a crucial issue.
Blattner, Peter   +2 more
core   +1 more source

Menopause, estrogens, progestins, or their combination on body weight and anthropometric measures [PDF]

open access: bronze, 2007
Angelo Cagnacci   +5 more
openalex   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Genetic aspects of calving, growth, and carcass traits in beef cattle [PDF]

open access: yes, 2003
The aim of this thesis was to learn more about the genetic background of calving, growth and carcass traits of beef cattle breeds in Sweden, and to assess the possibility of including calving traits and commercial carcass traits in the genetic evaluation.
Eriksson, Susanne
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Variogram investigation of covariance shape within longitudinal data with possible use of a krigeage technique as an interpolation tool: Sheep growth data as an example [PDF]

open access: yes, 2014
peer-reviewedMost quantitative traits considered in livestock evolve over time and several continuous functions have been proposed to model this change.
Chalh, A., El Gazzah, M.
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Changes in Alcohol Consumption, Eating Behaviors, and Body Weight during Quarantine Measures: Analysis of the CoCo-Fakt Study [PDF]

open access: gold, 2022
Stefanie Wessely   +13 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

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