Results 141 to 150 of about 558,138 (246)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

O potencial diagnóstico dos indicadores da obesidade centralizada

Revista de Saúde Pública
OBJETIVO: Tem sido sugerido que os indicadores da obesidade centralizada, representados pela relação entre as medidas das circunferências da cintura e do quadril e pela medida da circunferência da cintura, expressam distúrbios metabólicos diferentes ...
Ignez Salas Martins, Sheila Pita Marinho
doaj  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A new method to learn growth curves of beef cattle using a factorization approach [PDF]

, 2018
Alonso González, Jaime, Bahamonde Rionda, Antonio, Díez Peláez, Jorge, Luaces Rodríguez, Óscar   +3 more
core   +1 more source

Anthropometric profile of elite athletes of women´s futsal

Revista Brasileira de Cineantropometria e Desempenho Humano, 2005
The objective of the present study was to determinate the somatotype profile of professional players of futsal by their tactical function. The sample was composed by 112 futsal players from ten teams from seven states that were disputing the 10th ...
Marcelo Romanzini, Sandra Aires Ferreira, Marcos Roberto Queiroga   +2 more
doaj  

Interoceptive predictors of daily functioning in aging and their interaction with exteroceptive bodily representations. [PDF]

Front Psychol
Pasciucco MR, Bubbico F, Nunziata S, Iuliano S, Ruggiero G, Perrucci MG, Croce P, Costantini M, Ferri F.   +8 more
europepmc   +1 more source

Diagnostic Performance of BMI and Waist Circumference in Detecting Excess Adiposity. [PDF]

Obesity (Silver Spring)
Lin JC, Tandar CE, Bajaj SS, Stanford FC.   +3 more
europepmc   +1 more source

Expression of Concern: Dietary Compound Isoliquiritigenin Inhibits Breast Cancer Neoangiogenesis via VEGF/VEGFR-2 Signaling Pathway. [PDF]

PLoS One
PLOS One Editors.
europepmc   +1 more source

Adjusted effect size, area under the curve, and c-statistic for evaluating the association between uric acid and mortality in US adults using unweighted and survey-weighted regression, propensity, and prognostic score. [PDF]

PeerJ
Ahmed S, Dwivedi AK.
europepmc   +1 more source