Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore +20 more
wiley +1 more source
Water treatment and E. coli in drinking water: Household responses to (invisible) water quality risks. [PDF]
Kamei A, Soori BS.
europepmc +1 more source
DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li +25 more
wiley +1 more source
High-Speed X-Ray Imager 'Hayaka' and Its Application for Quick Imaging XAFS and in Coquendo 4DCT Observation. [PDF]
Yoneyama A +5 more
europepmc +1 more source
TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu +9 more
wiley +1 more source
Impact of Culinary Treatments on the Immunoreactivity of Soy Protein Isolates. [PDF]
Jędrusek-Golińska A +3 more
europepmc +1 more source
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi +16 more
wiley +1 more source
State-of-the-art assessment-based review of boiling heat transfer and friction factor correlations for NH<sub>3</sub>-H<sub>2</sub>O, NH<sub>3</sub>-LiNO<sub>3</sub> and NH<sub>3</sub>-LiNO<sub>3</sub>-H<sub>2</sub>O mixtures in a plate heat exchanger. [PDF]
Chauhan VKS, Sathyabhama A, Hegde RN.
europepmc +1 more source

