Results 241 to 250 of about 255,833 (288)

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

Impact of Cooking Method on the Physicochemical Properties, Digestibility, and Sensory and Flavor Profiles of Chinese Chestnuts. [PDF]

Foods
Song L, Xu M, Zhang K, Guo G, Huai L, Zhao Y, Wang T, Pan L, Cui R, Zhang L.   +9 more
europepmc   +1 more source

Tuning the Solid-State Hydrogen Release of Ammonia Borane by Entrapping the Intermediates: The Role of High-Boiling-Point Amines. [PDF]

Molecules
Bartoli M, Ferraro G, Etzi M, Lettieri S, Pirri CF, Bocchini S.   +5 more
europepmc   +1 more source

Experimental data for the rate of CO₂ release from seawater under vacuum at 30°C and ambient pressure at 100°C. [PDF]

Data Brief
Straatman P, Gazzani M, van Sark W.
europepmc   +1 more source

Prediction of SF₆ Replacement Gases Based on Machine Learning. [PDF]

ACS Omega
Ding G, Liu W, Ling M, Chen F, Liu Z, Yuan Q, Cheng L.   +6 more
europepmc   +1 more source

Stewarding the hospital sink drain: a narrative review of practical approaches for controlling gram negative pathogens in low- and middle-income countries. [PDF]

Antimicrob Resist Infect Control
Mmolai S, Gatonye T, Gopolang B, Tembo CV, Keatholetswe T, Coffin SE, Richard-Greenblatt M, Annavajhala MK, Hoar C, Bédard E, Moustafa A, Planet P, Strysko J.   +12 more
europepmc   +1 more source