Results 241 to 250 of about 216,398 (309)

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

Automated Analysis of Pollutants in Wastewater Using Atmospheric Pressure Gas Chromatography-Tandem Quadrupole Mass Spectrometer With Robotic Autosampler and Solid Phase Micro Extraction. [PDF]

J Sep Sci
Shinde D, Dhagat U, Murugan V, Gupta P, Tadala R, Karubothula B, Devireddy C, Stanislaus E, Salem SB, Elamin W, Brudecki G.   +10 more
europepmc   +1 more source

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

Sugar-Based Polyesters: From Glux-Diol Synthesis to Its Enzymatic Polymerization. [PDF]

ACS Omega
Acciaretti F, Pasquale A, Lombardo G, Damonte G, Petroni S, Leuzzi L, Mangiagalli M, Brocca S, Pellis A, Cipolla L.   +9 more
europepmc   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, EarlyView.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

High-Speed X-Ray Imager 'Hayaka' and Its Application for Quick Imaging XAFS and in Coquendo 4DCT Observation. [PDF]

Sensors (Basel)
Yoneyama A, Yasuda M, Yashiro W, Setoyama H, Takeya S, Kawamoto M.   +5 more
europepmc   +1 more source

Single Treatment Boiling Histotripsy Focused Ultrasound Ablation Neither Negates nor Enhances the Activity of α-CD40 in a Pancreatic Cancer Model. [PDF]

IEEE Trans Biomed Eng
Stepanechko M, Gamache A, Padilla F, Nemshick M, Kitelinger L, Conarroe C, DeWitt M, Hossack JA, Bullock TNJ.   +8 more
europepmc   +1 more source

Investigation of Phase-Change Droplets and Fast Imaging for Indicator Dilution Measurement of Flow. [PDF]

J Ultrasound Med
Zajac Z, Helfield B, Williams R, Sheeran P, Tremblay-Darveau C, Yoo K, Burns PN.   +6 more
europepmc   +1 more source

Ultracold cryogenic TEM with liquid helium and high stability. [PDF]

Proc Natl Acad Sci U S A
Rennich E, Sung SH, Agarwal N, Gates M, Kerns R, Hovden R, Baggari IE.   +6 more
europepmc   +1 more source

Seamless analysis of liquid samples by coupling a thermal desorption chip with ion mobility spectrometry. [PDF]

Anal Bioanal Chem
Fechner A, Drees C, Vautz W, Sielemann S, Telgheder U, Franzke J, Brandt S.   +6 more
europepmc   +1 more source