Results 61 to 70 of about 595,279 (265)

SINdex: Semantic INconsistency Index for Hallucination Detection in LLMs

IEEE Open Journal of the Computer Society
Large language models (LLMs) are increasingly deployed across diverse domains, yet they are prone to generating factually incorrect outputs—commonly known as “hallucinations.” Among existing mitigation strategies, uncertainty-based ...
Samir Abdaljalil, Parichit Sharma, Erchin Serpedin, Rachad Atat, Hasan Kurban   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Efficient Unified Framework for Difficulty-Controllable Question Generation: Large Language Models Enabling Active Learning Labeling and Prompt-Based Low-Rank Adaptation

IEEE Access
The task of Difficulty-Controllable Question Generation (QG) in reading comprehension is of great significance for improving the educational applicability of automatically generated questions. However, existing research faces two core challenges: 1) lack
Xiaohui Dong, Zhengluo Li
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

基于ISAA-Na的CABRI-BI1失流实验分析

He jishu
钠沸腾是钠冷快堆重大事故前的重要瞬态现象，进行钠冷快堆事故分析需要准确预测钠沸腾时的两相状态和冷却剂热力学参数。本文为钠冷快堆一体化分析程序ISAA-Na（Integrated Severe Accident Analysis code）开发了基于多气泡段塞假设的堆芯热工水力模型。使用ISAA-Na对高燃耗辐照堆芯（Cœur à Haut Bûrnup Irradiation，CABRI-BI1）失流实验进行了模拟和分析。与实验数据的对比表明，ISAA-Na相较于SAS4A、ASTEC ...
唐 绍伟, 张 斌, 冯 思棋, 雷 伊, 单 建强   +4 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

大鳞副泥鳅台湾种群(Paramisgurnus dabryanus ssp. Taiwan)及选育品系“赣红1号”(“Ganhong No.1”)体色早期发育和相关基因的表达分析

Haiyang yu huzhao
为探究大鳞副泥鳅台湾种群(Paramisgurnus dabryanus ssp. Taiwan, 以下简称台鳅)和选育系“赣红1号”(“Ganhong No.1”, 以下简称红鳅)体色发育形成过程中色素相关基因和通路的动态变化对体色发育及调控的影响，研究红鳅体色突变的形成机制，实验通过显微观察和荧光定量PCR等方法，探究了台鳅和红鳅成鱼5种鱼鳍色素细胞类型、早期体色发育的过程，以及不同发育时期14个体色相关基因(tyr、mitfa、foxd3、oca2、dct、tbx2a、kita、slc45a2 ...
胡 艳, 刘 毅, 马 爱军, 王 海华, 孙 志宾, 蒋 宇航, 曹 郡文, 张 皓, 黄 智慧, 马 本贺   +9 more
doaj   +1 more source