Results 21 to 30 of about 599 (119)

Merging Continuous Flow Technology, Photochemistry and Biocatalysis to Streamline Steroid Synthesis

Advanced Synthesis &Catalysis, Volume 365, Issue 23, Page 4024-4048, December 5, 2023., 2023
Abstract Since their structural elucidation in 1935, the introduction and substitution of functional groups and the modification of the steroidal scaffolds have been a fertile ground of research for synthetic and medicinal chemists. The discovery of steroids with hormonal and pharmacological activity has stimulated tremendous efforts to the development
Elena Tomarelli, Bruno Cerra, Francesco G. Mutti, Antimo Gioiello   +3 more
wiley   +1 more source

‘My mind pretty much went to mush’: A qualitative exploration of trenbolone in the performance and image enhancing drug community

Drug and Alcohol Review, Volume 42, Issue 6, Page 1566-1576, September 2023., 2023
Abstract Introduction There are a variety of harms associated with anabolic–androgenic steroids (AAS), with some AAS associated with an increased risk profile for users. Despite potentially different risk profiles, these harms are seldom discussed with respect to specific compounds although recent ethnographic research has identified a need to do so ...
Timothy M. Piatkowski, David L. Neumann, Matthew Dunn   +2 more
wiley   +1 more source

Investigations in carbon isotope ratios of seized testosterone and boldenone preparations

Drug Testing and Analysis, Volume 14, Issue 3, Page 514-518, March 2022., 2022
The carbon isotope ratios of black market products (n = 157 testosterone and n = 39 boldenone preparations) seized between 2013 and 2018 were investigated in order to prove their depleted 13C content compared with endogenously produced steroids. All boldenone and more than 95% of testosterone samples were found with δ13CVPDB‐values < −26‰.
Thomas Piper, Mario Thevis
wiley   +1 more source

Epigenetic modification‐dependent androgen receptor occupancy facilitates the ectopic TSPY1 expression in prostate cancer cells

Cancer Science, Volume 112, Issue 2, Page 691-702, February 2021., 2021
Our findings identify the regulation of DNA methylation, acting as a primary mechanism, on TSPY1 expression in PCa, and reveal that TSPY1 is an androgen‐AR axis‐regulated oncogene, suggesting a novel and potential target for PCa therapy. Abstract Testis‐specific protein Y‐encoded 1 (TSPY1), a Y chromosome‐linked oncogene, is frequently activated in ...
Xiangyou Leng, Mohan Liu, Dachang Tao, Bo Yang, Yangwei Zhang, Tianrong He, Shengyu Xie, Zhaokun Wang, Yunqiang Liu, Yuan Yang   +9 more
wiley   +1 more source

Anabolic‐Androgenic Steroid Misuse: Mechanisms, Patterns of Misuse, User Typology, and Adverse Effects

Journal of Sports Medicine, Volume 2021, Issue 1, 2021., 2021
Anabolic‐androgenic steroids (AAS) encompass a broad group of natural and synthetic androgens. AAS misuse is highly prevalent on a global scale, with the lifetime prevalence of AAS misuse in males being estimated to be around 6%, with 15 to 25% of male gym attendees using it at any one time.
Jack B. Ding, Marcus Z. Ng, Steven S. Huang, Mark Ding, Kevin Hu, Nancy J. Rehrer   +5 more
wiley   +1 more source

Evaluación de dos estimulantes hormonales para el engorde de toretes Brahman bajo pastoreo y bloques multinutricionales suplementarios

Siembra, 2016
La alimentación en la producción animal es un reto que enfrentan los agricultores al buscar que el animal alcance el peso ideal en el menor tiempo y al menor costo posible.
Eloy Castro, Carmen Pérez, Carlos Alberto Ortega, Diego Salazar Vizuete, Juan Pazmiño González   +4 more
doaj   +1 more source

Bioformation of boldenone and related precursors/metabolites in equine feces and urine, with relevance to doping control [PDF]

, 2019
Boldenone (1‐dehydrotestosterone) is an exogenous anabolic‐androgenic steroid(AAS) but is also known to be endogenous in the entire male horse and potentiallyformed by microbes in voided urine, the gastrointestinal tract, or feed resulting inits ...
Christopher J. Walker, Muir, Tessa, James Scarth, Walker, Christopher J., Andrew T. Kicman, Kim Wolff, Pamela Hincks, Viljanto, Marjaana, Hincks, Pamela, Scarth, James, Biddle, Simon, Kicman, Andrew T., Wolff, Kim; id_orcid, Tessa Muir, Simon Biddle, Marjaana Viljanto   +15 more
core   +1 more source

Evaluation of the Cardiac Protection Conferred by Proanthocyanidins in Grape Seeds against Development of Ehrlich Solid Tumors in Mice

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Examination of the antineoplastic effects of a range of chemical compounds is often undertaken via the transplantable tumor model of Ehrlich solid tumor (EST), which is a simulation of breast cancer. The purpose of this study was to explore how cardiac toxicity, damage, oxidative stress, and changes in the expressions of TNFα and apoptotic P53 ...
Maha Abdulrahman Aldubayan, Sivagnanam Thamilselvan   +1 more
wiley   +1 more source

Boldenone-induced apoptotic, structural, and functional alterations in the liver of rabbits

World Rabbit Science, 2015
Boldenone undecylenate (BOL) is an anabolic androgenic steroid used in livestock to improve growth and food conversion. This study investigated the actions of BOL on structure and functions of rabbit liver as well as the effects of its withdrawal ...
R.F. Mayada, M.S. Taghred, A.A. Haytham
doaj   +1 more source

EFFECT OF LYCOPENE IN AMELIORATION OF TESTICULAR AND RENAL TOXICITY INDUCED BY BOLDENONE UNDECYLENATE IN MALE ALBINO RATS

International Journal of Medical and Biomedical Studies, 2019
Background: The present study was designed to evaluate the relative ameliorating efficacy of lycopene against the deleterious effects of boldenone, an androgenic steroid, on the rat testis and kidney.  Materials and Methods: 40 male albino rats were divided into four groups; control group received intramuscular (i.m) injection of olive oil once a week;
Samar Ibrahim, Alshaimaa M. Said
openaire   +2 more sources