Results 21 to 30 of about 104,844 (248)

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane   +43 more
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza   +19 more
wiley   +1 more source

Claustrum Involvement in New Onset Refractory Status Epilepticus: A Systematic Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The claustrum sign is a distinctive neuroimaging finding characterized by bilateral T2/FLAIR hyperintensity of the claustrum, one of the most interconnected regions of the human brain. It was first described in new‐onset refractory status epilepticus (NORSE) and febrile infection–related epilepsy syndrome (FIRES).
Margherita Burani   +5 more
wiley   +1 more source

Engineering Nanoplatforms for Alzheimer's Disease Detection via Biomolecular Corona Proteomic and Lipidomic Profiling

open access: yesAdvanced Healthcare Materials, EarlyView.
Engineered nanoparticles capture disease‐specific biomolecular coronas that uncover hidden molecular features of Alzheimer's disease. Combined proteomic and lipidomic analyses reveal a characteristic shift in ribosomal machinery and energy metabolism, generating a multiomic fingerprint that supports accurate disease detection and opens new ...
Antonietta Greco   +7 more
wiley   +1 more source

Osservazioni paleografiche su due papiri greci conservati all’Archiginnasio di Bologna

open access: yesAnnali Online dell'Università di Ferrara. Sezione Lettere, 2015
The essay presents a palaeographical analysis and description of two fragments of Greek papyrus (2nd and 3rd centuries AD), that are preserved at the Archiginnasio Library in Bologna. The two fragments (entirely reproduced) had not yet been edited, hence
Sandro Bertelli
doaj   +1 more source

Sustainable Poly(Lactic Acid)/Graphene Oxide Bioelectronic Platform for Neurotransmitters Sensing and Tunable Stimulation of Astrocytes

open access: yesAdvanced Materials, EarlyView.
This work introduces sustainable PLA/graphene oxide bioelectronic interfaces featuring electrodes with tunable conductivity and strong electrocatalytic performance. These platforms were used to implement a new method for tuning astrocyte Ca2+ signaling and for the efficient detection of key biomarkers.
Alessandra Scidà   +15 more
wiley   +1 more source

Precision Switching and Coupled Motion in a [3]Rotaxane Molecular Machine

open access: yesAngewandte Chemie, EarlyView.
A [3]rotaxane, composed by two crown ether macrocycles and an axle presenting three recognition sites, is operated through both chemical and electrochemical stimuli. The position of the macrocycles is precisely controlled by sequential stimulation and the processes are fully reversible. The characterization of the system revealed the macrocycles affect
Leonardo Andreoni   +3 more
wiley   +2 more sources

Giacomo Lercaro, an Architect among Architects? The Scientific Planning of the “Seconda Bologna” between the 1950s and 1960s.

open access: yesHistories of Postwar Architecture
Giacomo Lercaro’s arrival in Bologna in the spring of 1952 and his appointment as cardinal the following year opened a 15-year period in which the Emilian city was at the center of important initiatives that gained notoriety both nationally and ...
Giovanni Bellucci
doaj   +1 more source

Covalent Attachment of Quaternary Ammonium Group to Geopolymer Surface With Silane Coupling Agent to Enable Simultaneous Adsorption of Cations and Anions

open access: yesAdvanced Materials Interfaces, EarlyView.
Modification of geopolymer surface with a silane coupling agent containing quaternary ammonium group enables the development of dual‐functioning ion exchanger for both cations and anions. In the present study, the performance of this material was demonstrated for the uptake of ammonium and nitrate from water.
Yangmei Yu   +7 more
wiley   +1 more source

Strong Coupling in all‐Polymer Planar Microcavities

open access: yesAdvanced Optical Materials, EarlyView.
Strong Coupling has been achieved in an all‐polymer microcavity with dielectric contrast Δn = 0.33 doped with TDBC. A Rabi splitting of 39 meV has been measured opening novel perspectives for polymer photonics. ABSTRACT In this work, strong coupling effect is observed in all‐polymer planar microcavities incorporating TDBC J‐aggregates dispersed into ...
Daniela Di Fonzo   +5 more
wiley   +1 more source

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