Results 191 to 200 of about 2,753 (283)

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh   +19 more
wiley   +1 more source

Chasing the perfida Albione: Anglo‐Italian productivity gap in the late 1930s

open access: yesThe Economic History Review, EarlyView.
Abstract This paper presents new estimates of Anglo‐Italian labour productivity levels in manufacturing in the late 1930s, derived using the standard single‐deflation approach. The findings confirm a substantial productivity gap between Italy and the United Kingdom at the aggregate level, alongside pronounced intersectoral heterogeneity.
Tancredi Salamone
wiley   +1 more source

Gender inequality in urban British Africa: Evidence from Anglican marriage registers

open access: yesThe Economic History Review, EarlyView.
Abstract We examine the colonial origins and evolution of gender inequality in mission schooling and formal labour force participation across six cities in British colonial Africa, using marriage register data for some 30,000 Anglican brides and grooms well‐positioned to benefit from colonial educational and employment opportunities.
Felix Meier zu Selhausen, Jacob Weisdorf
wiley   +1 more source

Updates on intra‐articular corticosteroid administration in horses

open access: yesEquine Veterinary Education, EarlyView.
Summary Intra‐articular (IA) corticosteroid administration in equine athletes has gained increased attention recently, particularly in racing. Despite widespread corticosteroid use in equine practice for decades, there are still a lack of equine‐specific studies to address key questions related to their use.
K. Tanner   +5 more
wiley   +1 more source

Investigating Crack Resistance Behavior of Polypropylene Using J integral, J‐R Curve and Fractographic Analysis

open access: yesFatigue &Fracture of Engineering Materials &Structures, EarlyView.
ABSTRACT In this study, the fracture response of polypropylene (PP) was assessed using J‐integral evaluation, J‐R curve construction, and fractography examination. J‐R and load–displacement curves were analyzed to determine critical loads and estimate J‐integral values based on standards established for polymer fracture testing, which led to the ...
N. Choupani   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy