Results 21 to 30 of about 24,376 (300)
Fides, bona fides, and bonus vir [PDF]
Journal of Law, Religion and State, 2017 This article investigates the link between the Roman notion of fides and the contemporary notion of fiduciary duties. Etymologically, the word “fiduciary” derives from fides .
openaire +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Природне право як основа морально-правових приписів у стародавньому Римі [PDF]
, 2008 У статті розглядаються проблеми ролі та місця в системі римського права концепції природного права. Автор вважає, що ця концепція дістала своє втілення у таких поняттях римського права, як добро (bona), справедливість (aequitas), добропорядність (bona ...
Шаркова, Ірина Миколаївна
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Wolves among us: some brief reflections on the bona fides of gendered violence in computer game art [PDF]
, 2015 The classification of computer games in Australia is a subject of expert discourse, but is not, itself, an expert function. It is carried out by community representatives (the classifiers), speaking for the community of reasonable people and applying ...
Jardine, Adam
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
International Journal of Communication, 2022 Paul Lazarsfeld’s upbringing was infused with the revolutionary potential and moral commitment of early 20th-century socialism. He was virtually raised by the leaders of the Austrian Social Democrats who frequented his mother’s salons, including ...
Joseph Malherek
doaj +2 more sources
Investigating the Routine Dispatch Tasks Performed by Police Officers
Safety, 2020 Police officers perform a variety of physical tasks that can range from deskwork to chasing down fleeing suspects on foot. If not sufficiently prepared these tasks can lead to an increased risk of injury or task failure.
Robin Orr +4 more
doaj +1 more source
Assessing the legality of coercive restructuring tactics in uk exchange offers [PDF]
, 2015 This article discusses bondholder exchange offers, a useful private debtrestructuring technique. In a typical offer, an under-performing issuer will seek to exchange its old bonds for new bonds with economically less favourable terms to bondholders, thus
Peel, Robert
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