Results 181 to 190 of about 3,541,930 (355)

Alumanyl silanides as multifunctional reagents for olefin cycloaddition, CO hydrosilylation, and reductive CO coupling. [PDF]

Chem Sci
Ludwig M, Voigtland J, Vasko P, Stigler S, Inoue S.   +4 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Design, Synthesis, Antimicrobial Activity and Molecular Docking of New 1,2,4-Triazepine, 1,3,4,6-Oxatriazepine and Pyridazino[1,2-<i>a</i>] Pyrimidine Derivatives. [PDF]

Pharmaceuticals (Basel)
Amri N, Abu-Hashem AA.
europepmc   +1 more source

Probability Approach in Estimating Value at Risk of Bond Portfolios for Effective Hedging

, 2020
Bavani Chandra Kumar, Ravindran Ramasamy, Zulkifflee Mohamed   +2 more
openalex   +1 more source

Effect of the tyrosine 96 hydrogen bond on the inactivation of cytochromeP‐450_caminduced by hydrostatic pressure [PDF]

, 1990
Carmelo Di Primo, Gaston Hui Bon Hoa, Pierre Douzou, Stephen G. Sligar   +3 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Characterization of the protonation and hydrogen bonding state of the histidine residues in IIAmtl, a domain of the phosphoenolpyruvate-dependent mannitol-specific transport protein

, 1992
Alard A. Van Dijk, Ruud M. Scheek, Klaas Dijkstra, Gea K. Wolters, George T. Robillard   +4 more
openalex   +2 more sources

Review [of \u3cem\u3eDying on Foreign Shores: Travel and Mobility in the Late-Antique West\u3c/em\u3e by Mark Handley] [PDF]

, 2013
Bond, Sarah E.
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Evaluation of SMART technique using Nano-silver fluoride and Silver Diamine Fluoride; evaluation of tooth discoloration and shear bond strength in primary molars. [PDF]

Saudi Dent J
Bakhurji EA, Al Sheikh R, Alamri AA, Alothman FA, Aldossary KE, Alghamdi FR, Alghamdi OS.   +6 more
europepmc   +1 more source