Results 81 to 90 of about 2,347,040 (191)

Frequency Of Bracket Bond Failure In Orthodontic Patients With Normal Over Bite And Deep Bite

Journal of Bahria University Medical and Dental College, 2017
Objective: To find out the frequency of bracket bond failure in patients with normal overbite and deep bite. Methodology: Sample consisted of 100 patients undergoing fixed orthodontic treatment at Orthodontic Department of Rawal Institute of Health ...
Ahmad Hasan
doaj  

Creep model of bond-degradation in deep granite based on variable radius particle clump

Scientific Reports
The creep failure of rocks is related to its microstructure, external loading and time. A nonlinear yield model was introduced to describe the variation in the cohesion and friction angle with plastic strain and intergranular stress.
Chunzhe Jin, Chuang Sun, Yunhe Ao, Dong Xue, Xin Lu, Qing Zhang   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Research progress in high-temperature failure behavior of MCrAlY metal bond-coat

Cailiao gongcheng
The MCrAlY(M=Ni, Co or NiCo)has become a widely used bond-coat material of thermal barrier coatings (TBCs) due to its advantages of high-temperature oxidation resistance and high thermal expansion coefficient, with the continuous increase in turbine ...
LIU Jiaqi, WANG Chaohui, LIN Wei, YOU Yuan, CHENG Weidong, DONG Meiling, WANG You, WANG Yuhang, ZHU Zhongyu, LIU Jinquan   +9 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Advanced chronic heart failure: A position statement from the Study Group on Advanced Heart Failure of the Heart Failure Association of the European Societyof Cardiology [PDF]

, 2007
Therapy has improved the survival of heart failure (HF) patients. However, many patients progress to advanced chronic HF (ACHF). We propose a practical clinical definition and describe the characteristics of this condition.
METRA, Marco, Heart, Failure Association of the European Society of Cardiology   +1 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Bond performance of recycled coarse aggregate concrete with rebar under freeze–thaw environment: A review

Nonlinear Engineering
In this article, a review focusing on the frost resistance of recycled coarse aggregate concrete (RAC) and the bond performance of RAC with rebar under freeze–thaw environment is carried out. The results show that there are still some controversies about
Wang Ting, Yang Xuechao, Zhang Weishen, Yang Qifan, Yang Deqiang, Li Bangxiang, Su Tian, Mei Xuefeng   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source