Results 81 to 90 of about 199,493 (265)

Debonding Analysis Model and Experimental Investigations on FRP Plates Reinforced SHCC Beams Under Three-point Bending

open access: yes工程科学与技术
ObjectiveStrain-hardening cement-based composites (SHCC) exhibit inherent characteristics of multiple microcracking under uniaxial tension and bending, which reduces stress concentration at the crack mouth and delays debonding failure between SHCC and ...
HU Jihong   +4 more
doaj  

Experimental Research on Longitudinal Steel Bar Bond Properties in Modified Recycled Aggregate Concrete Beam-Column Interior Joint under Cyclic Loading

open access: yesAdvances in Materials Science and Engineering, 2017
Three recycled aggregate concrete (RAC) beam-column interior-joint specimens (including two modified recycled aggregate concrete interior joints with replacement of fly ash ratio of 15%) were tested under cyclic loading in order to study the bond ...
Jia-Li Fu, Bing-Kang Liu, Jun-Wei Ma
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Numerical Parametric Analysis of Bond Coat Thickness Effect on Residual Stresses in Zirconia-Based Thermal Barrier Coatings

open access: yesHigh Temperature Materials and Processes, 2016
Numerical-based finite element investigation has been conducted to explain the effect of bond coat thickness on stress distribution in traditional and nanostructured yttria-stabilized zirconia (YSZ)-based thermal barrier coatings (TBC). Stress components
Abbas Musharaf   +2 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Study on the Bond Performance of Epoxy Resin Concrete with Steel Reinforcement

open access: yesBuildings
Epoxy resin concrete, characterized by its superior mechanical properties, is frequently utilized for structural reinforcement and strengthening. However, its application in structural members remains limited.
Peiqi Chen   +4 more
doaj   +1 more source

Bond behaviour of GFRP reinforced geopolymer cement concrete

open access: yesMATEC Web of Conferences, 2017
Bond plays a key role in the performance of reinforced concrete structures. Glass fibre reinforced polymer (GFRP) reinforcing bar and Geopolymer cement (GPC) concrete are promising alternative construction materials for steel bars and Ordinary Portland ...
Hailu Tekle Biruk   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

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