Results 31 to 40 of about 115,562 (259)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Geometallurgical model of the work index for a porphyry copper deposit by machine learning

FIGEMPA
The development of mining projects in the exploration and pre-feasibility stages involves challenges related to geological and processing heterogeneity and uncertainty due to variability in their primary and response attributes.
Nelson Jesús Ramos-Armijos, Marilú Calderón-Celis   +1 more
doaj   +1 more source

Inequalities on the Generalized ABC Index

Mathematics, 2021
In this work, we obtained new results relating the generalized atom-bond connectivity index with the general Randić index. Some of these inequalities for ABCα improved, when α=1/2, known results on the ABC index. Moreover, in order to obtain our results,
Paul Bosch, Edil D. Molina, José M. Rodríguez, José M. Sigarreta   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

EFFECT OF GRINDING MEDIA ON THE MILLING EFFICIENCY OF A BALL MILL

Rudarsko-geološko-naftni Zbornik, 2022
The size of grinding media is the primary factor that affects the overall milling efficiency of a ball mill (e.g. power consumption and particle size breakage).
Gamal S. Abdelhaffez, Ahmed A. Ahmed, Haitham M. Ahmed   +2 more
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Modeling and Systematic Analysis of Grinding Behavior for Overburden, Saprolite, and Their Mixtures

Applied Sciences
To date, the grinding behavior of saprolite and lateritic overburden mixtures remains poorly understood. The Bond Work Index (BWI) is the principal indicator used to determine the specific energy consumption during the grinding process.
Yunior Correa-Cala, Norman Toro, Yabriel Oliveros Silvente, Hugo Javier Angulo-Palma, Roger Samuel Almenares Reyes, Ayelen Dominguez Ramirez, Carlos Hernández Pedrera, Iván Salazar, Sandra Gallegos, Felipe M. Galleguillos-Madrid, Manuel Saldana, Alvaro Soliz   +11 more
doaj   +1 more source

The first multiplication atom-bond connectivity index of molecular structures in drugs

Saudi Pharmaceutical Journal, 2017
In the field of medicine, there are a large number of new drugs synthesis every year. Before entering the clinical stage, it needs a lot of work on drug testing of the various properties.
Wei Gao, Yiqiao Wang, Weifan Wang, Li Shi   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source