Results 71 to 80 of about 1,219,620 (312)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Terminal Patient’s Hopes for Connections Transcending Time

open access: yesAnthropology & Aging, 2012
Terminal cancer patients face not only issues unique to their diseases, but also issues rooted in their previous life experiences, including physical, social, psychological, and spiritual pain.
Megumi Kondo-Arita
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Valuation of Government Bonds: the Exchange Rate Is an Important Aspect

open access: yesActa Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2017
Interest rates are currently very low in the countries. In these countries bonds are issued with low or negative yields. In this paper, I empirically investigate the factors that affect the price of bonds.
Blanka Francová
doaj   +1 more source

The pricing of green bonds: Are financial institutions special?

open access: yesJournal of Financial Stability, 2019
The financial system plays a major role in the transition to a low-carbon economy. We investigate this issue analysing the recent developments and challenges in the bond and debt markets. First, we study the pricing of green bonds at issuance.
Serena Fatica   +2 more
semanticscholar   +1 more source

Bond Laddering and Bond Indexing: An Empirical Comparison

open access: yesSSRN Electronic Journal, 2016
Bond laddering and bond indexing have been widely accepted approaches to bond investing among retail investors. However, bond laddering has virtually been ignored in both the academic literature and most of the popular investment textbooks. One thing both approaches have in common is that they are passive strategies with no attempt whatsoever to beat ...
C. Sherman Cheung, Peter Miu
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Methods for assessing the effectiveness of use loan capital for its core

open access: yesУченые записки Российской академии предпринимательства, 2021
The use of borrowed capital is characterized by its core. At the present stage with the help of the key components of the cost of financial credit, the value of funds raised through the issuance of bonds, the value of commercial (commercial) credit in ...
I. N. Vyachina, F. H. Khayrullina
doaj  

Bond Mutual Funds vs. Bond Exchange Traded Funds: Evaluation of Risk Adjusted Performance

open access: yesAdministrative Sciences, 2019
Growing acceptance of passive bond exchange traded funds (ETFs) and actively managed bond mutual funds has exposed the need to find a divide between these two comparatively similar types of instrument.
Jelena Stankevičienė, Ieva Petronienė
doaj   +1 more source

Green Bonds: Effectiveness and Implications for Public Policy

open access: yesEnvironmental and Energy Policy and the Economy, 2019
This paper studies green bonds, a relatively new instrument in sustainable finance. I first describe the market for green bonds and characterize the “green bond boom” witnessed in recent years.
C. Flammer
semanticscholar   +1 more source

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