Results 81 to 90 of about 2,349,577 (305)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Anisotropy in Fracking: A Percolation Model for Observed Microseismicity

open access: yes, 2014
Hydraulic fracturing (fracking) using high pressures and a low viscosity fluid allow the extraction of large quantiles of oil and gas from very low permeability shale formations.
Norris, J. Quinn   +2 more
core   +1 more source

INTERNATIONAL TRENDS IN THE FIELD OF FOREIGN INVESTMENTS* [PDF]

open access: yesEconomica, 2020
Foreign investments represent placements in the territory of a country made by non-resident investors. Depending on the approach position, they are considered as forms of international investment and part of international investment market.
Iulita BIRCA   +2 more
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Polymer chain scission at constant tension - an example of force-induced collective behaviour

open access: yes, 2011
The breakage of a polymer chain of segments, coupled by anharmonic bonds with applied constant external tensile force is studied by means of Molecular Dynamics simulation.
Milchev, A.   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Climate risk assessment of the sovereign bond portfolio of European Insurers [PDF]

open access: yes, 2019
In the first collaboration between climate economists, climate financial risk modellers and financial regulators, we apply the CLIMAFIN framework described in Battiston at al.
Battiston, Stefano   +4 more
core  

Comparison of Bond Character in Hydrocarbons and Fullerenes

open access: yes, 1996
We present a comparison of the bond polarizabilities for carbon-carbon bonds in hydrocarbons and fullerenes, using two different models for the fullerene Raman spectrum and the results of Raman measurements on ethane and ethylene.
A.A. Maradudin   +17 more
core   +2 more sources

EWOLUTION OF CHINA'S FINANCIAL SYSTEM

open access: yesJournal of Modern Science, 2019
Financial system is a “ blood circulation” of country economy. Since China is attempting to establish modern economy ( within authoritarian political system though) the creation of institutions and regulations of the system became crucial.
Krystyna Palonka
doaj   +1 more source

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