Results 121 to 130 of about 606,113 (264)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Androgen Receptor (AR) Pathophysiological Roles in Androgen Related Diseases in Skin, Metabolism Syndrome, Bone/Muscle and Neuron/Immune Systems: Lessons Learned from Mice Lacking AR in Specific Cells [PDF]

, 2013
Chawnshang Chang, Shuyuan Yeh, Soo Ok Lee, Ta‐Min Chang   +3 more
openalex   +1 more source

Active IgG4-related disease with bone marrow involvement: a report of 2 cases and case-based review [PDF]

, 2022
Shiyi Liu, Hui Wang, Tao Su
openalex   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

The importance of retaining physical functions to prevent skeletal‐related events in multiple myeloma patients with bone disease [PDF]

, 2022
Hirokazu Miki, Shingen Nakamura, Masahiro Oura, Masafumi Nakamura, Ryohei Sumitani, Kimiko Sogabe, Mamiko Takahashi, Tomoko Maruhashi, Takeshi Harada, Shiro Fujii, Hirofumi Hamano, Masateru Kondo, Naoto Okada, Itsuro Endo, Masahiro Abe   +14 more
openalex   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Beyond immunosuppressive effects: dual roles of myeloid-derived suppressor cells in bone-related diseases. [PDF]

Cell Mol Life Sci, 2021
Ling Z, Yang C, Tan J, Dou C, Chen Y.
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Non-bone-derived exosomes: a new perspective on regulators of bone homeostasis

Cell Communication and Signaling
Accumulating evidence indicates that exosomes help to regulate bone homeostasis. The roles of bone-derived exosomes have been well-described; however, recent studies have shown that some non-bone-derived exosomes have better bone targeting ability than ...
Ping Wang, Wenkai Shao, Zilin Li, Bo Wang, Xiao Lv, Yiyao Huang, Yong Feng   +6 more
doaj   +1 more source

Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases. [PDF]

Front Bioeng Biotechnol, 2021
Khan S, Siddique R, Huanfei D, Shereen MA, Nabi G, Bai Q, Manan S, Xue M, Ullah MW, Bowen H.   +9 more
europepmc   +1 more source