Results 91 to 100 of about 1,148,938 (358)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Skeletal responses to spaceflight [PDF]

The role of gravity in the determination of bone structure is elucidated by observations in adult humans and juvenile animals during spaceflight. The primary response of bone tissue to microgravity is at the interface of the mineral and matrix in the ...
Arnaud, Sara B., Morey-Holton, Emily
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Cancellous bone and theropod dinosaur locomotion. Part II—a new approach to inferring posture and locomotor biomechanics in extinct tetrapod vertebrates [PDF]

, 2018
This paper is the second of a three-part series that investigates the architecture of cancellous bone in the main hindlimb bones of theropod dinosaurs, and uses cancellous bone architectural patterns to infer locomotor biomechanics in extinct non-avian ...
Abourachid, Abourachid, Adachi, Alexander, Allen, Allen, Allmendinger, Amson, Anderson, Anderson, Andrada, Attene, Barak, Barak, Beaupré, Beer, Bell, Bergmann, Bergmann, Biewener, Biewener, Bishop, Bishop, Bishop, Bishop, Bishop, Blob, Bona, Bonnan, Bonnan, Boyle, Brassey, Bright, Bright, Bryant, Butcher, Calow, Campoli, Cardozo, Carey, Carrano, Carrano, Carrano, Carter, Carter, Chadwick, Charles, Chinsamy-Turan, Christen, Christen, Christen, Christen, Coelho, Cowin, Currey, Delp, Delp, Dumont, Erickson, Fajardo, Fernandez, Fischer, Gatesy, Gatesy, Gatesy, Gatesy, Gefen, Geraldes, Geraldes, Giarmatzis, Giddings, Gilbert, Goetz, Goldstein, Gosnell, Griffin, Grossi, Guldman, Haines, Hayes, Houssaye, Hudson, Hudson, Huiskes, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hébert, Jacobs, Jacobs, Jacobson, Jang, Jang, Jang, Kabel, Kambic, Kazemi, Kivell, Koch, Lamas, Lanyon, Lanyon, Lerner, Liao, Lovejoy, Lovejoy, MacLatchy, Maga, Main, Marsh, Martelli, Matarazzo, McGowan, McHenry, Medler, Miller, Modenese, Muir, Mullender, Odgaard, O’Neill, Page, Patak, Pauwels, Paxton, Pedotti, Phillips, Polk, Pontzer, Radin, Rankin, Reed, Regnault, Reilly, Ren, Richmond, Roberts, Rose, Rubenson, Rubenson, Rudman, Ruimerman, Ryan, Ryan, Ryan, Schaller, Sheffield, Smith, Steele, Stoessel, Stops, Su, Su, Sverdlova, Taylor, Tsegai, Tsubota, Tsubota, Turner, Turner, Turner, Ulrich, Valente, van Arkel, Van Der Meulen, van der Meulen, Vander Sloten, Verner, Volpato, Wang, Wink, Winter, Witte, Wolff, Wroe, Zadpoor, Zinoviev   +180 more
core   +3 more sources

Spinal fusions: bone and bone substitutes [PDF]

European Spine Journal, 2000
Vertebral arthrodesis is one of the most commonly performed, yet incompletely understood, procedures in spinal surgery. Despite major progress in internal fixation techniques, the high rate of nonunions indicates that physiologic, biologic and molecular events that are crucial to this process are not well known.
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Ecological succession of a Jurassic shallow-water ichthyosaur fall. [PDF]

, 2014
After the discovery of whale fall communities in modern oceans, it has been hypothesized that during the Mesozoic the carcasses of marine reptiles created similar habitats supporting long-lived and specialized animal communities.
A Glover, A Kaim, A Kaim, A Kaim, A Sheldon, C Bristow, C Clausen, C Gaillard, C Smith, C Smith, CE Braby, CR Smith, DL Distel, DM Martill, DM Martill, DM Martill, F Garcia-Pichel, F Garcia-Pichel, G Bianucci, H Astibia, HS Chafetz, J Taylor, JA Hogler, JA Hogler, JA Massare, JW Deming, K Amano, K Duff, K Olu-Le Roy, L Lundsten, LA Levin, M Hrs-Brenko, ME Jans, ME Williams, P Dando, PA Allison, PB Wignall, PD Taylor, R Bromley, R Motani, R Motani, R Riding, R Twitchett, R Vrijenhoek, RC Vrijenhoek, RS Shapiro, S Danise, S Danise, S Danise, S Danise, S Dominici, S Golubic, S Kiel, S Kiel, S Kiel, T Treude, V De Buffrenil, V Thiel, Z Lewy   +58 more
core   +3 more sources

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source