Results 81 to 90 of about 271,941 (310)

Targeted Regeneration of Bone in the Osteoporotic Human Femur

, 2011
We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system.
Gerard R. Ridgway, Poole, KES, Kenneth E. S. Poole, Borggrefe, J, Paul M Mayhew, Treece, GM, Ridgway, GR, Paul M. Mayhew, Andrew H. Gee, Graham M Treece, Mayhew, PM, Gee, AH, Graham M. Treece, Andrew H Gee, Gerard R Ridgway, Jan Borggrefe, Kenneth E S Poole   +16 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Bone geometry and volumetric bone mineral density in girls with Turner syndrome of different pubertal stages

, 2010
Objective An increased rate of fractures has been reported in patients with Turner syndrome (TS). We aimed to assess bone geometry and volumetric bone mineral density (vBMD) at the radius in girls with TS and to evaluate the relationships between bone
Kolouskova, Stanislava, Rittweger, Jörn, Soucek, Ondrej, Jan Lebl, Zdenek Sumnik, Snajderova, Marta, Ondrej Cinek, Zdenek Hlavka, Stanislava Kolouskova, Lebl, Jan, Marta Snajderova, Rocek, Miloslav, Cinek, Ondrej, Joern Rittweger, Miloslav Rocek, Ondrej Soucek, Sumnik, Zdenek   +16 more
core   +1 more source

Development and validation of a paediatric long-bone fracture classification : a prospective multicentre study in 13 European paediatric trauma centres [PDF]

, 2011
Background: The aim of this study was to develop a child-specific classification system for long bone fractures and to examine its reliability and validity on the basis of a prospective multicentre study.
Marzi, Ingo, Ralf Kraus, Lutz von Laer, Kraus, Ralf, Kaiser, Martin, Röder Christoph, von Laer Lutz, Schneidmüller, Dorien, Martin Kaiser, Dietrich, Daniel, Christoph Röder, Dietrich, Daniel J., Ingo Marzi, Kaiser Martin, Marzi Ingo, Röder, Christoph, Schneidmüller Dorien, Dietrich Daniel, von Laer, Lutz, Laer, Lutz von, Kraus Ralf, Dorien Schneidmüller, Daniel Dietrich   +22 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Mineral maturity and crystallinity index are distinct characteristics of bone mineral [PDF]

, 2010
The purpose of this study was to test the hypothesis that mineral maturity and crystallinity index are two different characteristics of bone mineral. To this end, Fourier transform infrared microspectroscopy (FTIRM) was used.
Delmas, Pierre D., Delmas, Pierre, D., Boivin, Georges, Panczer, Gérard, Rey, Christian, Farlay, Delphine   +5 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Osteoblastoma of the Os Capitatum

Case Reports in Orthopedics, 2014
An osteoblastoma is a primary benign bone tumor, which is rarely seen in hand bones. Osteoblastoma is generally seen in spine, pelvis, and long bones. However, there are a few case reports of osteoblastoma in wrist and hand bones. To our knowledge, up to
Çağrı Kaptan, Halil Atmaca
doaj   +1 more source

Temporary brittle bone disease:association with intracranial bleeding [PDF]

, 2013
We report 20 infants aged between 1 month and 6 months found to have subdural bleeding and also multiple unexplained fractures in a pattern similar to that described earlier as temporary brittle bone disease. Child abuse seemed unlikely as a cause of the
Paterson, Colin R., Monk, Elizabeth
core   +1 more source