Results 91 to 100 of about 271,941 (310)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Self-calibrating 3D-ultrasound-based bone registration for minimally invasive orthopedic surgery

, 2006
Intraoperative freehand three-dimensional (3-D) ultrasound (3D-US) has been proposed as a noninvasive method for registering bones to a preoperative computed tomography image or computer-generated bone model during computer-aided orthopedic surgery (CAOS)
C.S.K. Chan, G.P. Penney, Carter, TJ, Chan, CSK, Barratt, D C, Hawkes, DJ, Edwards, PJ, T.J. Carter, M. Slomczykowski, P.J. Edwards, D.J. Hawkes, Chan, C S K, Carter, T J, D.C. Barratt, Edwards, P J, Barratt, DC, Slomczykowski, M, Penney, GP, Hawkes, D J, Penney, G P   +19 more
core   +1 more source

Deficiency of the bone mineralization inhibitor NPP1 protects against obesity and diabetes [PDF]

, 2014
The emergence of bone as an endocrine regulator has prompted a re-evaluation of the role of bone mineralization factors in the development of metabolic disease.
Elspeth M. Milne, Ahmed, S Faisal, Zhu, Dongxing, Morton, Nicholas M, Millan, José Luis, MacRae, Vicky E, Mathieu Ferron, José Luis Millan, Dongxing Zhu, Nicholas M. Morton, Ferron, Mathieu, Farquharson, Colin, Karsenty, Gerard, Gerard Karsenty, Carmen Huesa, Vicky E. MacRae, Morton, Nicholas M., James D. Glover, Ahmed, S. Faisal, Glover, James D, Colin Farquharson, Huesa, Carmen, MacRae, Vicky E., S. Faisal Ahmed, Glover, James D., Milne, Elspeth M, Milne, Elspeth M., Farquharson, Colin; id_orcid   +27 more
core   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Inhibition of Acid Phosphatase Enzyme Activity in the Presence of Noncrystalline Calcium Phosphate and Nanocrystalline Calcium Apatite: a Preliminary Study

, 2009
*Background* Our bones are remodelled repeatedly during life. A new and “healthy” bone tissue replaces the old one. Accordingly, the bone degrading cells, the osteoclasts, prefer old and fatigued bone.
Yassen Pekounov
core  

Bone density and neuromuscular function in older competitive athletes depend on running distance

, 2013
Summary Individuals who are involved in explosive sport types, such as 100-m sprints and long jump, have greater bone density, leg muscle size, jumping height and grip strength than individuals involved in long-distance running.
Kusy, Krzysztof, Rittweger, Jörn, Belavy, Daniel, Gast, Ulf, Armbrecht, Gabriele, Rawer, R, Zielinski, Jacek, Felsenberg, Dieter, Winwood, Keith, Lexy, H   +9 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

A genome-wide scan for quantitative trait loci affecting limb bone lengths and areal bone mineral density of the distal femur in a White Duroc × Erhualian F₂ population

BMC Genetics, 2008
Background Limb bone lengths and bone mineral density (BMD) have been used to assess the bone growth and the risk of bone fractures in pigs, respectively. It has been suggested that limb bone lengths and BMD are under genetic control.
Ma Junwu, Ai Huashui, Liu Sanfeng, Ren Jun, Yang Bin, Yang Guangcheng, Guo Yuanmei, Mao Huirong, Brenig Bertram, Huang Lusheng   +9 more
doaj   +1 more source

pQCT-assessed relationships between diaphyseal design and cortical bone mass and density in the tibiae of healthy sedentary and trained men and women

, 2013
In a pQCT study of running-trained and untrained men and women we had shown that bone mass distribution along the tibia was adapted to the usage-derived stress pattern.
Rittweger, Jörn, Mortarino, Pablo, Feldman, Sara, Reina, P. S., Cointry, Gustavo, Capozza, R. F., Nocciolino, L. M., Ferretti, José Luis   +7 more
core  

Use of three isotopes to calibrate human bone radiocarbon determinations from Kainapirina (SAC), Watom Island, Papua New Guinea

, 2005
In archaeological dating, the greatest confidence is usually placed upon radiocarbon results of material that can be directly related to a defined archaeological event.
Green, Roger, Petchey, Fiona
core   +1 more source