Results 111 to 120 of about 1,124,156 (362)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

open access: yesFEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian   +6 more
wiley   +1 more source

Evaluation of dental implant induced bone remodelling by using a 2D Finite Element model [PDF]

open access: yes, 2007
Dental implantation is one of the most common dental restorative techniques to replace a missing tooth. The longevity and the stability of the dental implant can be directly impacted by two factors: 1) The degree of integration between the implant and ...
Ichim, Ionut   +4 more
core  

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

open access: yesFEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić   +3 more
wiley   +1 more source

Evaluation of sarcoidosis with multiple bone lesions using both bone scintigraphy and FDG-PET/CT: A case report

open access: yesRespiratory Medicine Case Reports
Sarcoidosis is a systemic granulomatous disease; however, the incidence of bone sarcoidosis is relatively rare. The short tubular bones of the hands and feet are most frequently affected, while the vertebrae and the pelvic bones are rarely involved.
Naohiro Kadoma   +7 more
doaj   +1 more source

Incorporation of glycine-2-C-14 in acid-insoluble proteins of rat bones and teeth during hypokinesia and administration of thyrocalcitonine [PDF]

open access: yes
A forced limitation of the motor activity in rats (from 5 to 60 days) results in reduced incorporation of glycine 2-C14 in the total acid insoluble proteins of limb bones and its increase in the teeth and mandibular-maxillary bones.
Potkin, V. Y.   +3 more
core   +1 more source

The Makapansgat Limeworks grey breccia: hominids, hyaenas, hystricids or hillwash? [PDF]

open access: yes, 1980
Main articleThe question of the origin of the Makapansgat Limeworks grey breccia is here considered from two viewpoints: (a) the accumulation of bones within a catchment area; and (b) the possible concentration of the bones in their final resting ...
Collett, M. H.   +2 more
core  

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

open access: yesFEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson   +5 more
wiley   +1 more source

Effect of six-month hypokinesia in dogs on mineral component, reconstruction and mechanical properties of bone tissue [PDF]

open access: yes
Ca45 incorporation into the bones of the limbs, particularly in the area of the muscle attachment increased in dogs as a result of 6 month hypokinesia.
Korzhenyants, V. A.   +4 more
core   +1 more source

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