Results 171 to 180 of about 5,337,728 (405)

Interplay of integrins and selectins in metastasis

open access: yesMolecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva   +2 more
wiley   +1 more source

Enostosis (osteopoikylosis, bone islands) in medieval (14- 15th centuries) skeletons [PDF]

open access: yes, 2008
Enostosis (i.e. osteopoikylosis, bone islands, etc.) is a focus of mature cortical bone within cancellous bone. Bone islands are often recognized on radiographic pictures taken for other diagnostical purpose. The authors examined x-ray images of 652 long
Farkas, Gyula L., Józsa, László
core  

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Clinical study of 3D printed personalized prosthesis in the treatment of bone defect after pelvic tumor resection

open access: yesJournal of Orthopaedic Translation, 2021
Background: /Objective: In recent years, prostheses have been widely used for limb reconstruction after pelvic tumour resection. However, prostheses are associated with problems leading to tumour recurrence, poor implant matching, defects after tumour ...
Lin Xu   +6 more
doaj  

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Characterization of the elemental deposits in fossils from the Cradle of Humankind in south Africa and modern bones from the same geological area [PDF]

open access: yes, 2010
Bones are complex, composite tissues consisting of inorganic calcium phosphate crystallites precipitated in an organized organic collagen matrix. However, diagenetic processes alter the original chemical composition and structure of the mineral and the ...
Nhauro, Godwin
core  

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