Results 51 to 60 of about 2,717,930 (384)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Histomorphometric analysis of the femoral neck in patients with and without femoral neck fracture [PDF]

Acta Ortopédica Brasileira, 2015
OBJECTIVE: To determine, through bone histomorphometry in femoral neck, whether there are differences in the cancellous bone of the proximal femur from female patients over 60 years old who had femoral neck fracture and similar patients who did not have ...
Caio Gonçalves de Souza, Vanda Jorgetti, Luciene Machado dos Reis, Alberto Tesconi Croci   +3 more
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Influence of zoledronic acid and low-intensity laser on collagen fibers during the bone repair process [PDF]

Acta Cirúrgica Brasileira
Purpose: To evaluate collagen fibers during the bone repair process in critical defects created in the tibias of rats, treated with zoledronic acid (AZ) associated with low-level laser therapy (LLLT).
Paola Aguilar, Angélica Cristina Fonseca, Gustavo Pompermaier Garlet, Jéssica Lemos Gulinelli, Pâmela Letícia Santos   +4 more
doaj   +1 more source

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.

American Journal of Human Genetics, 2002
Osteoporosis is a complex disease that affects >10 million people in the United States and results in 1.5 million fractures annually. In addition, the high prevalence of osteopenia (low bone mass) in the general population places a large number of people
R. D. Little, J. Carulli, R. D. Del Mastro, J. Dupuis, M. Osborne, C. Folz, S. P. Manning, P. Swain, Shan-Chuan Zhao, Brenda K. Eustace, M. Lappe, L. Spitzer, S. Zweier, K. Braunschweiger, Y. Benchekroun, Xintong Hu, R. Adair, L. Chee, M. FitzGerald, C. Tulig, A. Caruso, N. Tzellas, A. Bawa, B. Franklin, Shannon M. McGuire, X. Nogués, G. Gong, K. Allen, A. Anisowicz, Arturo J Morales, P. Lomedico, Susan M. Recker, P. van Eerdewegh, R. Recker, Mark L. Johnson   +34 more
semanticscholar   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Evolutionary patterns of bone histology and bone compactness in xenarthran mammal long bones. [PDF]

PLoS ONE, 2013
Bone microstructure reflects physiological characteristics and has been shown to contain phylogenetic and ecological signals. Although mammalian long bone histology is receiving increasing attention, systematic examination of the main clades has not yet ...
Fiona R Straehl, Torsten M Scheyer, Analía M Forasiepi, Ross D MacPhee, Marcelo R Sánchez-Villagra   +4 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Predictive Modelling of Bone Age through Classification and Regression of Bone Shapes [PDF]

, 2014
Bone age assessment is a task performed daily in hospitals worldwide. This involves a clinician estimating the age of a patient from a radiograph of the non-dominant hand.
Bagnall, Anthony, Davis, Luke
core   +1 more source

Validation of a 3D-printed human temporal bone model for otology surgical skill training

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2021
Hypothesis: Three-dimensional (3D) printed temporal bones are comparable to cadaveric temporal bones as a training tool for otologic surgery. Background: Cadaveric temporal bone dissection is an integral part of otology surgical training.
Wade W. Chien, Melville J. da Cruz, Howard W. Francis   +2 more
doaj