Results 81 to 90 of about 1,124,156 (362)
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Morphometric investigations on the vertebral column of the rock partridges (alectoris graeca) and pheasants (phasianus colchicus) [PDF]
Eurasian Journal of Veterinary SciencesAim: The aim of this study was to determine macroanatomy and the number of cervical, thoracal and lumbar parts of the vertebral column in rock partridges (Alectoris graeca) and pheasants (Phasianus colchicus).
Mehmet Fatih Yüksel +1 more
doaj
Increased sclerostin associated with stress fracture of the third metacarpal bone in the Thoroughbred Racehorse [PDF]
, 2018 Objectives: The exact aetiopathogenesis of microdamage induced long bone fractures remains unknown. These fractures are likely the result of inadequate bone remodeling in response to damage.
Henson, F, Hopper, N, Singer, E
core +2 more sources
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
Descriptive Anatomy and Three-Dimensional Reconstruction of the Skull of the Early Tetrapod Acanthostega gunnari Jarvik, 1952 [PDF]
, 2003 The early tetrapod Acanthostega gunnari is an iconic fossil taxon exhibiting skeletal morphology reflecting the transition of vertebrates from water onto land. Computed tomography data of two Acanthostega skulls was segmented using visualization software
Chan, HL +5 more
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Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Symmetry and isometry of human adult hyoid bone: A cadaveric study in North Indian population
CHRISMED Journal of Health and Research, 2018 Introduction: Hyoid bone fracture is one of the most integral parts of internal examination during autopsy of hanging, ligature strangulation, or a throttling case.
Bhavna Kalyan +2 more
doaj +1 more source
Early evidence of stone tool use in bone working activities at Qesem Cave, Israel [PDF]
, 2016 For a long while, the controversy surrounding several bone tools coming from pre-Upper Palaeolithic contexts favoured the view of Homo sapiens as the only species of the genus Homo capable of modifying animal bones into specialised tools.
Barkai, Ran +8 more
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Nature Reviews Disease Primers, 2020 Bone is the most frequent site for metastasis for many cancers, notably for tumours originating in the breast and the prostate. Tumour cells can escape from the primary tumour site and colonize the bone microenvironment. Within the bone, these disseminated tumour cells, as well as those arising in the context of multiple myeloma, may assume a state of ...
Robert E Coleman +9 more
openaire +4 more sources
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source