Results 111 to 120 of about 3,540,813 (330)

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Elution and Mechanical Strength of Vancomycin-Loaded Bone Cement: In Vitro Study of the Influence of Brand Combination

PLoS ONE, 2016
Antibiotic-loaded bone cement (ALBC) is widely used in orthopaedic surgery for both prevention and treatment of infection. Little is known about the effect of different brand combinations of antibiotic and bone cement on the elution profile and ...
Shen-Hsun Lee, Ching-Lung Tai, Szu-Yuan Chen, Chih-Hsiang Chang, Yu-Han Chang, Pang-Hsin Hsieh   +5 more
semanticscholar   +1 more source

Controlled release properties and final macroporosity of a pectin microspheres–calcium phosphate composite bone cement [PDF]

, 2010
The use of calcium phosphate cements (CPC) is restricted by their lack of macroporosity and poor drug release properties. To overcome these two limitations, incorporating degradable polymer microparticles into CPC is an attractive option, as polymer ...
Rodriguez, Frédéric, Freche, Michèle, Lacout, Jean-Louis, Girod-Fullana, Sophie, Ternet, Hélène, Girod Fullana, Sophie, S. Girod Fullana, J.L. Lacout, M. Freche, H. Ternet, F. Rodriguez   +10 more
core   +1 more source

Industrial Symbiosis as a Neglected Opportunity in Industrial Decarbonisation Pathways: Qualitative Insights From the Australian Manufacturing Sector

Business Strategy and the Environment, EarlyView.
ABSTRACT Industrial symbiosis (IS) represents a key strategy for industrial decarbonisation (ID) by converting one industry's waste into valuable inputs for another, reducing emissions and resource extraction. Scientific studies have explored the concept, implementation approaches and theoretical foundations of IS.
Marzieh Dehghan Niri, A S M Monjurul Hasan, Andrea Trianni   +2 more
wiley   +1 more source

Hierarchical chirality of bone cement drives osteoinduction via integrin dependent signaling to accelerate critical bone defect regeneration

Journal of Nanobiotechnology
The biocompatibility and degradability of calcium phosphate bone cement (CPC) make it a potential therapeutic strategy to critical bone defects repair. However, it fails to create a stable extracellular microenvironment for inducing stem cells osteogenic
Jinzhou Du, Liang Yang, Lingchi Kong, Tengfei Lou, Ai Yang, Chao Zhou, Yun Qian, Cunyi Fan   +7 more
doaj   +1 more source

Five‐year tomographic and clinical evaluation of the socket shield technique: Case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background The socket shield technique, one modality of partial extraction therapy, aims to preserve periodontal tissues and maintain the buccal alveolar bone volume following immediate implant placement or in prosthetic pontic sites, by the strategic maintenance of a tooth root fragment.
Renan Dalla, Khalila C. Cotrim, Rafael A. Siqueira, Eduardo C. Kalil   +3 more
wiley   +1 more source

Environment Friendly Sustainable End‐Of‐Life Solutions for Plastic Components in Indian Automotive Industries

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Growing concerns about the environmental and social consequences of plastics around the world, manufacturing industries are associated with business are focusing on sustainable end‐of‐life options‐based solutions which aim at increasing the product life cycle.
Sivakumar Kirupanandan, Deepak Mathivathanan, Jayakrishna Kandasamy, Michele Mosca   +3 more
wiley   +1 more source

Development of an injectable composite for bone regeneration [PDF]

, 2013
With the development of minimally invasive surgical techniques, there is a growing interest in the research and development of injectable biomaterials especially for orthopedic applications.
Belime, Agathe, Girod Fullana, Sophie, JACQUART, S., El Kissi, Nadia, TADIER, S., PIGASSE, C., CORDIER, D., Rey, Christian, Galliard, Hélène, Girod-Fullana, Sophie, BROUILLET, F., Fatnassi, Mohammed, FATNASSI, M., ANAGNOSTOU, F., Cordier, Delphine, Brouillet, Fabien, Tadier, Solène, Roques, Christine, Bignon, Aurélien, AUZELY-VELTY, R., Anagnostou, Fani, Auzély-Velty, Rachel, SIADOUS, R., GALLIARD, H., Bareille, Reine, Combes, Christèle, BAREILLE, R., GIROD-FULLANA, S., EL KISSI, N., Siadous, Robin, BIGNON, A., Jacquart, Sylvaine, AMÉDÉE, J., ROQUES, C., Hénocq-Pigasse, Christel, Fatnassi, Mohamed, Amédée, Joelle, REY, C., BELIME, A., COMBES, C.   +39 more
core   +1 more source

Dental development in the tropical gar (Atractosteus tropicus) and the evolution of vertebrate dentitions

Developmental Dynamics, EarlyView.
Abstract Background Dentitions have diversified enormously during vertebrate evolution, involving reductions, modifications, or allocations to prey seizing and processing regions. A combination of ancient and novel features related to dental and oropharyngeal apparatuses is found in extant lineages of non‐teleost fishes, such as the gars.
Anna Pospisilova, Jan Stundl, Lenin Arias‐Rodriguez, Robert Cerny, Vladimír Soukup   +4 more
wiley   +1 more source