Results 31 to 40 of about 588,712 (307)

Novel mutations in BMP1 result in a patient with autosomal recessive osteogenesis imperfecta

Molecular Genetics & Genomic Medicine, 2021
Background Osteogenesis imperfecta (OI) is a rare heritable bone disorder that is characterised by increased bone fragility and recurrent fractures. To date, only 19 OI patients have been reported, as caused by BMP1 gene mutations, worldwide.
Lei Xi, Shanshan Lv, Hao Zhang, Zhen‐Lin Zhang   +3 more
doaj   +1 more source

Analysis benefits of a second Allo-HSCT after CAR-T cell therapy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia who relapsed after transplant

Frontiers in Immunology, 2023
BackgroundChimeric antigen receptor (CAR) T-cell therapy has demonstrated high initial complete remission (CR) rates in B-cell acute lymphoblastic leukemia (B-ALL) patients, including those who relapsed after transplant.
Xing-yu Cao, Jian-ping Zhang, Yan-li Zhao, Min Xiong, Jia-rui Zhou, Yue Lu, Rui-juan Sun, Zhi-jie Wei, De-yan Liu, Xian Zhang, Jun-fang Yang, Peihua Lu, Peihua Lu   +12 more
doaj   +1 more source

Mechanical behavior of osteoporotic bone at sub-lamellar length scales [PDF]

, 2015
Osteoporosis is a disease known to promote bone fragility but the effect on the mechanical properties of bone material, which is independent of geometric effects, is particularly unclear.
Anna eShipov, Asa eBarber, Asa eBarber, Ines eJimenez-Palomar, Ron eShahar   +4 more
core   +2 more sources

Tibial cortex transverse transport facilitating healing in patients with recalcitrant non-diabetic leg ulcers

Journal of Orthopaedic Translation, 2021
Summary: Objective: The treatment of recalcitrant not-diabetic leg ulcers remains challenging. Distraction osteogenesis is accompanying by angiogenesis and neovascularization in the surrounding tissues.
Xinyu Nie, Xiaocong Kuang, Guangwei Liu, Zhaowei Zhong, Yi Ding, Jie Yu, Jie Liu, Shanlang Li, Liexun He, Hongjie Su, Wencong Qin, Jinmin Zhao, Qikai Hua, Yan Chen   +13 more
doaj   +1 more source

Myeloma-derived IL-32γ induced PD-L1 expression in macrophages facilitates immune escape via the PFKFB3-JAK1 axis

OncoImmunology, 2022
Multiple myeloma (MM) is characterized by an accumulation of monoclonal plasma cells within the bone marrow (BM). Macrophages are an abundant component of myeloma BM microenvironment and support survival of the malignant cells and foster myeloma ...
Yang Liu, Haimeng Yan, Huiyao Gu, Enfan Zhang, Jingsong He, Wen Cao, Jianwei Qu, Ruyi Xu, Liqin Cao, Donghua He, Jinna Zhang, Yifan Hou, Zhen Cai   +12 more
doaj   +1 more source

Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury. [PDF]

, 2018
Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis.
Jiang, Bin, Jiang, Longfeng, Ke, Bibo, Li, Changyong, Lu, Ling, Ni, Xuhao, Wang, Han, Wang, Xuehao, Zhang, Feng, Zhu, Qiang   +9 more
core   +2 more sources

Efficacy Analysis of Selection of Distal Reference Point for Tibial Coronal Plane Osteotomy during Total Knee Arthroplasty: A Literature Review

Orthopaedic Surgery, 2021
Total knee arthroplasty is an effective treatment for end‐stage knee osteoarthritis. The tibial platform osteotomy must take full account of the coronal plane, the sagittal plane, and the rotational alignment of the tibial prosthesis.
Jie Men, Han‐guang Liang, Zhi‐wei Wang, Peng Sun, Wei Feng   +4 more
doaj   +1 more source

High serum IL-17A is associated with bone destruction in newly diagnosed multiple myeloma patients

Frontiers in Oncology, 2022
BackgroundMultiple myeloma (MM) is a malignant proliferative disease of the blood system, characterized by the abnormal growth of clonal plasma cells in the bone marrow.
Mengmeng Dong, Jinna Zhang, Qingxiao Chen, Donghua He, Haimeng Yan, Gaofeng Zheng, Xiaoyan Han, Jingsong He, Zhen Cai, Zhen Cai   +9 more
doaj   +1 more source

S-allylcysteine Improves Blood Flow Recovery and Prevents Ischemic Injury by Augmenting Neovasculogenesis. [PDF]

, 2017
Studies suggest that a low level of circulating human endothelial progenitor cells (EPCs) is a risk factor for ischemic injury and coronary artery disease (CAD). Consumption of S-allylcysteine (SAC) is known to prevent CAD.
Chao, Che-Yi, Chiang, En-Pei Isabel, Chiu, Shao-Chih, Rodriguez, Raymond L, Syu, Jia-Ning, Tang, Feng-Yao, Tsai, Shu-Yao, Yang, Mei-Due   +7 more
core   +1 more source

Clinical characteristics of 10 Chinese patients with melorheostosis and identification of a somatic MAP2K1 variant in one case

Molecular Genetics & Genomic Medicine, 2022
Background Melorheostosis (MEL) is an exceptionally rare sclerosing bone dysplasia with asymmetrically exuberant bone formation and soft tissue lesions in a segmental distribution.
Xiaojun Han, Yang Xu, Zhanying Wei, Chun Wang, Hua Yue, Zhenlin Zhang   +5 more
doaj   +1 more source