Results 51 to 60 of about 48,008 (252)
Effect of stapedotomy in otosclerosis patients with advanced hearing loss
Turkish Archives of Otorhinolaryngology, 2009 Objectives:The aim of this study is to evaluate the efficiency of the surgery in otosclerosis patients with advanced hearing loss.Methods:The charts of 28 patients (30 ears) operated for otosclerosis with mean air conduction threshold greater than 70 dB ...
Fatma Çaylaklı +3 more
doaj +1 more source
A Novel Dentary Bone Conduction Device Equipped with Laser Communication in DSP
Sensors, 2021 In this study, we designed a dentary bone conduction system that transmits and receives audio by laser. The main objective of this research was to propose a complete hardware design method, including a laser audio transmitter and receiver and digital ...
Jau-Woei Perng +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Effect of otosclerosis surgery on tinnitus
Turkish Archives of Otorhinolaryngology, 2008 Objectives:The aim of this study is to investigate the possible correlation between tinnitus and hearing level and the effect of surgery on tinnitus in otosclerosis patients with tinnitus.Methods:In this study, 55 patients (59 ears) operated for ...
Fatma Çaylaklı +2 more
doaj +1 more source
International Archives of Otorhinolaryngology, 2016 Introduction Hearing loss is the most common clinical finding in patients with malformation of the external ear canal. Among the possibilities of treatment, there is the adaptation of hearing aids by bone conduction and the adaptation of implantable ...
Maria Fernanda Capoani Garcia Mondelli +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source