Results 121 to 130 of about 300,410 (306)

Diagnosis and management of bone cysts

Bone cysts are benign, fluid-filled lesions primarily occurring in the metaphyseal regions of tubular and flat bones, such as the humerus and femur. These lesions are commonly seen in children and adolescents during periods of rapid bone growth.
Devaraju, Deepak Channarayapattana, Boregowdanapalya, Anitha   +1 more
core   +1 more source

Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases

Advanced Science, EarlyView.
There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia, Hui You, Ke Zhang, Hui Jiang, Hongping Liu, Lianghua Liu, Aijie Zhang, You Zhou   +7 more
wiley   +1 more source

Total Hip Replacement in Fracture of Hip with Unicameral Bone Cyst – A Rare Case Report

Journal of Orthopaedic Case Reports
Introduction: Unicameral (simple) bone cysts (UBCs) are fluid-filled intramedullary cavities commonly seen in the metaphysis of long bones in young patients under the age of 20 years.
Sarang Shete, Sachin Bharadwaj, Hemlata Khanapure   +2 more
doaj   +1 more source

Direct steroid injections in the treatment of single bone cysts

, 1988
In the past, conventional surgical procedures for treatment of single bone cysts (curettage and bone grafting through a limited cortical window) were not satisfactory, showing a recurrence rate around 30-40%.
M. CAMPANACCI, CAPANNA, RODOLFO
core  

Treatment of aneurysmal bone cysts by introduction of demineralized bone and autogenous bone marrow.

, 2005
BACKGROUND: On the assumption that an aneurysmal bone cyst has an intrinsic potential to heal by ossification, a new, minimally invasive protocol was developed.
Delloye, Christian, Docquier, Pierre-Louis   +1 more
core   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Reconstruction of Bone Defects after Operations on Voluminous Maxillary Cysts

, 2005
The authors treated 125 patients with odontogenic jaw cysts of the volume larger than 2 cm3. In 75 of them the cystectomy was followed by reconstruction of the bone defect by lyophilized griaded allogenic spongious bone supplied by the Tissue Bank of the
J. Novotný, M. Geierová, J. Pazdera, V. Zbořil, P. Tvrdý, Z. Kolář   +5 more
core  

The pathogenesis and significance of menisceal cysts

, 1979
From a total of 1571 surgically excised menisci, 112 (7.1 per cent) were found by gross and microscopic examination to contain one or more cysts. All of these cysts were associated with tears, either primarily horizontal or with a horizontal component ...
HJ Barrie
core   +1 more source

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source