Results 121 to 130 of about 258,405 (265)

Tissue Engineering for Massive Bone Defects: The Volumetric Scaling Problem and Strategies to Solve It. [PDF]

Bioengineering (Basel)
Mosaid S, Jihad Y, Jihad M, Marudanayagam A, Lee P.   +4 more
europepmc   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

A bioprinted periosteum organoid enables functional repair of critical-sized bone defects. [PDF]

Bioact Mater
Chen Z, Huang K, Zhang Z, Chen P, Yu Q, Tang Y, Tan J, Zhang J, Qu Y, Dai Q, Dong S, Luo F, Dou C.   +12 more
europepmc   +1 more source

Self‐Assembly of Organic–Inorganic Copolymers Toward Bio‐Inspired Cementitious Composites

Advanced Science, EarlyView.
Organic–inorganic copolymerization of calcium silicate hydrate and thioctic acid produces a self‐organized nanocomposite inspired by the disordered collagen–mineral architecture of trabecular bone. The resulting material combines a compressive strength above 300 MPa with intrinsic physical reprocessibility, retaining over 80% of its strength and energy
Zonglin Xie, Suning Li, Fuwen Zhong, Gongkun Xiang, Mustapha Jamaa Garba, Yi Tian, Jun Wu, Zhiwu Yu, Qiang Yuan   +8 more
wiley   +1 more source

Forearm Nonunion and Segmental Bone Defects: A Focused Review of Masquelet Reconstruction and Free Vascularized Bone Grafting. [PDF]

Orthop Res Rev
Saad R, Saadeh J, Assaf F, Saber A, Abouzahr S, Kiwan E, Ghanem W, Badra M, Moucharafieh R.   +8 more
europepmc   +1 more source

Does Defective Bone Lead to Defective Muscle?

Journal of Bone and Mineral Research, 2015
openaire   +2 more sources

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

A microenvironment-responsive injectable hydrogel with core-shell nanoplatforms for sequential treatment of infected bone defects. [PDF]

Mater Today Bio
Han X, Chen H, Liu Y, Su Y, Gong H, Ma S, Sun D, Wang J, Wang Y, Chen W, Zhao J.   +10 more
europepmc   +1 more source

OTUD6A‐Mediated Deubiquitination of PRDX1 Protects Against Oral Ulcer by Restoring Mitochondrial Function

Advanced Science, EarlyView.
In human oral keratinocytes, OTUD6A promoted cell migration by deubiquitinating and stabilizing PRDX1. Conversely, OTUD6A deficiency reduced PRDX1 stability, triggering mitochondrial dysfunction and aggravating OU progression. ABSTRACT Oral ulcers (OU), as the most highly prevalent and recurrent oral mucosal lesion, have an unclear pathogenesis that ...
Xiaoyu Sun, Ruiwei Jia, Xingbei Pan, Rui Huang, Jiahong Chen, Ziyi Yao, Lei Yin, Jun Ma, Hongjieliang Wang, Xinyu Huang, Yilin Ma, Yifan Ping, Yuanyuan Chen, Huining Wang, Shengbin Huang, Guang Liang   +15 more
wiley   +1 more source

Clinical efficacy of Masquelet technique in the treatment of tibial and fibular bone defects caused by severe gunshot wounds. [PDF]

Front Med (Lausanne)
Sun Q, Cong Y, Sun W, Liu X, Guo B, Zhao C, Hou B, Liu Y, Zhou D.   +8 more
europepmc   +1 more source