Results 91 to 100 of about 3,479,474 (250)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Spinal Deformity, Dorsal Kyphosis and Bone Mineral Density

Türk Osteoporoz Dergisi, 2003
It has been show that spine deformity index is a better indicator of the functional capacity of the osteoporotic patient than the number of vertebral fractures.
Banu Kuran
doaj  

Bone density and its importance in orthodontics

Journal of Oral Biology and Craniofacial Research, 2013
Background: Researchers have generally focused on tissue reactions occurring within the periodontal ligament and bone to find possible explanation for various clinical phenomena, with less attention being paid to the inherent bone density.
Tina Chugh, Abhay Kumar Jain, Raj Kumar Jaiswal, Praveen Mehrotra, Rachita Mehrotra   +4 more
doaj   +1 more source

Prediction of risk of fracture in the tibia due to altered bone mineral density distribution resulting from disuse: a finite element study [PDF]

, 2014
The disuse-related bone loss that results from immobilisation following injury shares characteristics with osteoporosis in post-menopausal women and the aged, with decreases in bone mineral density leading to weakening of the bone and increased risk of ...
Allan, David B, Gislason, Magnus K., Coupaud, Sylvie, Allan, David B., Gislason, Magnus, Sasagawa, Keisuke, Tanabe, Yuji, Tanner, K. Elizabeth, Purcell, Mariel   +8 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Torus Palatinus: A New Anatomical Correlation with Bone Density in Postmenopausal Women

, 2003
The observation that subjects who have a striking oral exostosis, called torus palatinus, also tended to have normal or high bone densities prompted us to examine an unselected population referred for bone density assessment for a possible correlation ...
Hubert, Janet, Insogna, Karl, Johns, William, Belsky, Joseph, Hamer, Josie   +4 more
core  

Relative Contribution of Trabecular and Cortical Bone to Primary Implant Stability: An In vitro Model Study

Journal of Pharmacy and Bioallied Sciences
Background: Primary implant stability is a crucial factor for the successful osseointegration and long-term success of dental implants. The contribution of trabecular and cortical bone to primary implant stability is not well understood.
Trinanjali Bera, Bhavna Jha Kukreja, Chetan Sharma, Vivek V. Gupta, Priya Patel, Parul Singhal, Manish S. Jadhav, Naina Pattnaik   +7 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Bone mineral density and body composition in girls with idiopathic central precocious puberty before and after treatment with a gonadotropin-releasing hormone agonist

Clinics, 2012
OBJECTIVES: Idiopathic central precocious puberty and its postponement with a (gonadotropin-releasing hormone) GnRH agonist are complex conditions, the final effects of which on bone mass are difficult to define. We evaluated bone mass, body composition,
Sandra B. Alessandri, Francisco de A. Pereira, Rosângela A. Villela, Sonir R. R. Antonini, Paula C. L. Elias, Carlos E. Martinelli Jr., Margaret de Castro, Ayrton C. Moreira, Francisco J. A. de Paula   +8 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source