Results 71 to 80 of about 1,047,443 (356)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Biomechanical Computed Tomography analysis (BCT) for clinical assessment of osteoporosis. [PDF]

, 2020
The surgeon general of the USA defines osteoporosis as "a skeletal disorder characterized by compromised bone strength, predisposing to an increased risk of fracture." Measuring bone strength, Biomechanical Computed Tomography analysis (BCT), namely ...
Bouxsein, ML, Clarke, BL, Cosman, F, Keaveny, TM, Khosla, S, Orwoll, ES, Siris, ES   +6 more
core  

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Bone Mineral Density in Men - Original Investigation

Türk Osteoporoz Dergisi, 2007
Aims: This study is designed to evaluate bone mineral density (BMD) in men who attend to Physical Medicine and Rehabilitation outpatient clinic. Patients and Medhods: 42 men were included into the study.
Duygu Geler Külcü, Burcu Yanık
doaj  

Relation of vertebral deformities to bone density, structure, and strength. [PDF]

, 2010
Because they are not reliably discriminated by areal bone mineral density (aBMD) measurements, it is unclear whether minimal vertebral deformities represent early osteoporotic fractures.
Boutroy, Bouxsein, Bouxsein, Crawford, Crawford, DeLong, Eckstein, Eswaran, Ferrar, Fink, Genant, Genant, Harrell, Keaveny, Kirmani, Laib, Lentle, MacNeil, Marshall, Melton, Melton, Melton, Melton, Melton, Melton, Pollintine, Riggs, Seeman, Silva, Sornay-Rendu, Yeh   +30 more
core   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Bone Mineral Density Assessment in Ankylosing Spondylitis and Characteristics of Bone Turnover Parameters

Türk Osteoporoz Dergisi, 2005
Ankylosing spondylitis, characterised with excessive new bone formation and calcification in spine and peripheral joints, causes osteoporosis which is a general component of inflammatory arthritis.
Füsun Şahin, Nurdan Kotevoğlu, Banu Kuran   +2 more
doaj  

3D Micron-scale Imaging of the Cortical Bone Canal Network in Human Osteogenesis Imperfecta (OI) [PDF]

, 2013
Osteogenesis imperfecta (OI) is a genetic disorder leading to increased bone fragility. Recent work has shown that the hierarchical structure of bone plays an important role in determining its mechanical properties and resistance to fracture. The current
Albert, Carolyne, Busse, Bjoern, Harris, Gerald F., Jameson, John R., Smith, Peter A.   +4 more
core   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Bone density and its importance in orthodontics

Journal of Oral Biology and Craniofacial Research, 2013
Background: Researchers have generally focused on tissue reactions occurring within the periodontal ligament and bone to find possible explanation for various clinical phenomena, with less attention being paid to the inherent bone density.
Tina Chugh, Abhay Kumar Jain, Raj Kumar Jaiswal, Praveen Mehrotra, Rachita Mehrotra   +4 more
doaj   +1 more source