Results 141 to 150 of about 9,532 (200)

Stromal Defense Against Cancer: An Unprecedented Mechanism Limiting Cancer Invasion Into the Bone

Cancer Science, EarlyView.
The roles of nonimmune systems in tumor regulation remain largely undefined. This article introduces a new concept, “stromal defense against cancer (SDAC),” which is based on recent findings that the periosteum actively responds to tumor proximity and physically impedes tumor invasion into bone.
Masayuki Tsukasaki, Hiroshi Takayanagi
wiley   +1 more source

Time-dependent improvement of quality of life with teriparatide or alendronate therapy: a JOINT-05 sub-analysis. [PDF]

J Bone Miner Metab
Mori S, Tanaka S, Kuroda T, Hagino H, Soen S.   +4 more
europepmc   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

ROMosozumab early experience in female patients with severe osteoporosis in an Italian real-world setting, the ROMEO study. [PDF]

Osteoporos Int
Adami G, Bartezaghi M, Montanari F, Piccinelli A, Pollastri F, Mastropaolo F, Giorgio F, Benini C, Fassio A, Rossini M, Gatti D, Fornari R, Viapiana O.   +12 more
europepmc   +1 more source

Equine botulism

Equine Veterinary Journal, EarlyView.
Abstract Botulism is a severe and often fatal disease in equine patients worldwide. Clostridium botulinum is a ubiquitous soil organism which produces a potent neurotoxin resulting in neuromuscular blockade and flaccid paralysis in affected animals. Definitive diagnosis is often impractical or impossible, leading to diagnosis and treatment based on ...
Kali Slavik, Robert Whitlock, Amy Johnson   +2 more
wiley   +1 more source

Case report on possible causes of severe osteoporosis: diffuse panbronchiolitis. [PDF]

Osteoporos Int
Cheng R, Zhang L.
europepmc   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Medication-Related Osteonecrosis of the Jaw: An Evidence-Based 2025 Position Statement from a Korean Multidisciplinary Task Force. [PDF]

Endocrinol Metab (Seoul)
Kim JW, Kong SH, Kim JY, Kwak MK, Kim JY, Oh JH, Park HY, Kim B, Lee YK, Han JJ, Kim MY, Choi YJ, Kwon YD, Song KS, Kim BJ, Kim SJ, Baek SH, Lee DO, Choi HS, Kim HY, Kwon TG.   +20 more
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Bisphosphonates with high bone-resorption-capacity promote osteonecrosis of the jaw development after tooth extraction in mice. [PDF]

J Bone Miner Metab
Kubo R, Tajiri R, Yamada H, Nakayama H, Miyamoto T.   +4 more
europepmc   +1 more source