Results 121 to 130 of about 51,588 (239)

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

3 months vs 12 months of romosozumab for postmenopausal osteoporosis (LIDA): an open-label, non-inferiority, randomised controlled trial. [PDF]

Lancet Diabetes Endocrinol
Leder BZ, Ramchand SK, Jordan M, Ryan S, Patnaik A, Lee H, Tsai JN.   +6 more
europepmc   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

Recommendations for bone-directed therapy in patients with neuroendocrine tumour skeletal metastases at the New Zealand National Neuroendocrine Tumour Multidisciplinary Meeting. [PDF]

Intern Med J
Radley G, Elston MS, Lawrence B, Boyle V.   +3 more
europepmc   +1 more source

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Non-union after bisphosphonate-associated atypical femoral fractures: a review of the current literature. [PDF]

Eur J Orthop Surg Traumatol
Dowling J, Marsh S, O'Grady J.
europepmc   +1 more source

Neo‐Taphonomic Analysis of Prey Bone Remains Accumulated by Golden Eagle (Aquila chrysaetos): A Case of Nests in Southern France

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT The golden eagle (Aquila chrysaetos) nests in rock cavities where it accumulates prey bone remains during the breeding season. Because nests can be reoccupied from year to year, these faunal elements can form remarkable bone accumulations and, in the sub‐fossil record, be mixed with assemblages derived from human or other predator activities ...
Juliette Ripond, Véronique Laroulandie, Jean‐Baptiste Mallye, Renaud Nadal, Patrick Bayle, Christian Itty   +5 more
wiley   +1 more source

Anti-Osteoporotic Medication-Related Jaw Osteonecrosis: A Descriptive Analysis of the European EudraVigilance Database

Acta Médica Portuguesa
Sofia Ferreira Azevedo, Cláudia Pinto Oliveira, Ana Rita Prata, Inês Cunha, Anabela Barcelos   +4 more
doaj   +1 more source

Large, rugged and remote: The challenge of wolf–livestock coexistence on federal lands in the American West

People and Nature, EarlyView.
Abstract The expansion of grey wolves (Canis lupus) across the western United States, including on public lands used for extensive livestock grazing, requires tools and techniques for reducing wolf–livestock conflict and supporting coexistence. We examined approaches used on forested lands managed by the U.S.
Robert M. Anderson, Susan Charnley, Jeff Vance Martin, Kathleen Epstein   +3 more
wiley   +1 more source

Conversion to Complete, Parenchyma-Sparing Resection after Prolonged Denosumab for Bilateral Multifocal Pulmonary Metastases from Giant Cell Tumor of Bone: A Case Report. [PDF]

Ann Thorac Cardiovasc Surg
Omura S, Sasaki A, Anazawa U, Eguchi K.
europepmc   +1 more source