Results 1 to 10 of about 40,867 (262)

Current comprehensive understanding of denosumab (the RANKL neutralizing antibody) in the treatment of bone metastasis of malignant tumors, including pharmacological mechanism and clinical trials

Frontiers in Oncology, 2023
Denosumab, a fully humanized monoclonal neutralizing antibody, inhibits activation of the RANK/RANKL/OPG signaling pathway through competitive binding with RANKL, thereby inhibiting osteoclast-mediated bone resorption.
Junjie Lu, Desheng Hu, Yan Zhang, Chen Ma, Lin Shen, Bo Shuai   +5 more
doaj   +2 more sources

Modeling rebound bone loss following denosumab discontinuation and sequential zoledronate therapy in TgRANKL osteoporotic mice [PDF]

Front Endocrinol (Lausanne)
BackgroundReceptor activator of nuclear factor-κB ligand (RANKL) plays a central role in regulating osteoclast formation and bone resorption, while its inhibition by the monoclonal antibody denosumab serves as an effective antiresorptive treatment for ...
Rinotas V, Ntouskou E, Dragolia M, Ntafis V, Yavropoulou M, Anastasilakis A, Makras P, Douni E.   +7 more
europepmc   +2 more sources

Denosumab Regulates Titanium Particles-Induced Macrophages Inflammation and Osteolysis by Targeting the ST18/PARP1 Interaction. [PDF]

Orthop Surg
Objective This study aims to investigate the role of Denosumab and its downstream target ST18 in wear particle‐induced macrophage inflammation and osteolysis, and to explore the underlying mechanisms involved in aseptic loosening (AL) of prosthetic ...
Chen Z, Yang F, Yu Y, Chen J, Ye J, Ding Y.   +5 more
europepmc   +2 more sources

Oral management of patients treated with denosumab for giant cell tumor of bone: A retrospective study at the University Hospitals of Strasbourg

Oral Oncology Reports, 2023
Objectives: Giant cell tumor of bone (GCTB) is defined as a rare intermediate-grade mesenchymal tumor. The first-line treatment was surgery but since the 2010s, denosumab is a medical therapeutic option that can stop progression of GCTBs with a high ...
P. Klienkoff, N. Weingertner, J.-E. Kurtz, F. Bornert   +3 more
doaj   +1 more source

The Activation of PDGFRβ on Mononuclear Stromal/Tumor Cells in Giant Cell Tumor of Bone After Denosumab Treatment. An Immunohistochemical Study of Five Cases

Pathology and Oncology Research, 2022
Due to the relatively high recurrence rate and the destructive nature of the tumor, the treatment of giant cell tumor is still a challenge. Denosumab appeared to be a promising candidate as a therapeutic drug.
Imre Antal, Zsuzsanna Pápai, Miklós Szendrői, Tamás Perlaky, Katalin Dezső, Zoltán Lippai, Zoltán Sápi   +6 more
doaj   +1 more source

Risk factors associated with skeletal-related events following discontinuation of denosumab treatment among patients with bone metastases from solid tumors: A real-world machine learning approach

Journal of Bone Oncology, 2022
Background: Clinical practice guidelines recommend the use of bone-targeting agents for preventing skeletal-related events (SREs) among patients with bone metastases from solid tumors.
Dionna Jacobson, Benoit Cadieux, Celestia S. Higano, David H. Henry, Basia A. Bachmann, Marko Rehn, Alison T. Stopeck, Hossam Saad   +7 more
doaj   +1 more source

Preoperative denosumab treatment in patients with giant cell bone tumors in limbs: A retrospective study using propensity score matching

Cancer Medicine, 2023
Background and Objectives Denosumab is recommended for advanced giant cell tumor of bone (GCTB) that is unresectable or resectable with unacceptable morbidity.
Yongfu Huang, Mingxian Xu, Bo Wang, Zhiqiang Zhao, Tiao Lin, Gang Huang, Junqiang Yin, Xianbiao Xie, Jingnan Shen, Changye Zou   +9 more
doaj   +1 more source

A 5-year retrospective cohort study of denosumab induced medication related osteonecrosis of the jaw in osteoporosis patients

Scientific Reports, 2022
Denosumab has been suggested as a first-line therapy for osteoporotic patients. However, a standardized protocol for the prevention of denosumab induced medication-related osteonecrosis of the jaw (MRONJ) has not yet been established. The purpose of this
Seoyeon Jung, Jaeyeon Kim, Jin Hoo Park, Ki-Yeol Kim, Hyung Jun Kim, Wonse Park   +5 more
doaj   +1 more source

Pre-operative denosumab is associated with higher risk of local recurrence in giant cell tumor of bone: a systematic review and meta-analysis

BMC Musculoskeletal Disorders, 2020
Background In 2013, denosumab was introduced as peri-operative adjuvant treatment for giant cell tumor (GCT) of bone as it inhibits osteoclast activity.
Xi Chen, Hairui Li, Shibai Zhu, Yiou Wang, Wenwei Qian   +4 more
doaj   +1 more source

Four-Year Teriparatide Followed by Denosumab vs. Continuous Denosumab in Glucocorticoid-Induced Osteoporosis Patients With Prior Bisphosphonate Treatment

Frontiers in Endocrinology, 2021
ObjectivesIn our previous 24-month study, we observed that teriparatide had some advantages over denosumab for bone mineral density (BMD) in glucocorticoid-induced osteoporosis (GIO) patients with prior bisphosphonate treatment.
Yasuaki Hirooka, Yasuaki Hirooka, Yuji Nozaki, Saki Okuda, Masafumi Sugiyama, Koji Kinoshita, Masanori Funauchi, Itaru Matsumura   +7 more
doaj   +1 more source