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Macrophages and bone metastasis
Journal of Experimental Medicine, 2023 In the prostate bone metastasis microenvironment, macrophages activate a cascade that involves Activin A, the extracellular matrix, and SRC kinase and drives resistance to anti-androgen therapy. These findings (Li et al., 2023. J. Exp. Med.https://doi.org/10.1084/jem.20221007) have broad implications, including metastasis diversity in different tissue ...
Diletta Di Mitri +2 more
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Osteocytes and Bone Metastasis [PDF]
Frontiers in Endocrinology, 2020 Bone is the most frequent site of breast cancer and prostate cancer metastasis, and one of the most common sites of metastasis for many solid tumors. Once cancer cells colonize in the bone, it imposes a major clinical challenge for the treatment of the disease, and fatality rates increase drastically.
Manuel A. Riquelme +2 more
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Insights into immuno-oncology drug development landscape with focus on bone metastasis
Frontiers in Immunology, 2023 Bone is among the main sites of metastasis in breast, prostate and other major cancers. Bone metastases remain incurable causing high mortality, severe skeletal-related effects and decreased quality of life.
Tiina E. Kähkönen +4 more
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Clinicomics-guided distant metastasis prediction in breast cancer via artificial intelligence
BMC Cancer, 2023 Background Breast cancer has become the most common malignant tumour worldwide. Distant metastasis is one of the leading causes of breast cancer-related death.
Chao Zhang +12 more
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The Biology of Bone Metastasis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2017 Bone metastasis, or the development of secondary tumors within the bone of cancer patients, is a debilitating and incurable disease. Despite its morbidity, the biology of bone metastasis represents one of the most complex and intriguing of all oncogenic processes. This complexity derives from the intricately organized bone microenvironment in which the
Esposito, Mark +2 more
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Cells, 2022 Bone is the most common site of metastasis in breast cancer. Metastasis is promoted by acidosis, which is associated with osteoporosis. To investigate how acidosis could promote bone metastasis, we compared differentially expressed genes (DEGs) in MDA-MB-
Ana Sayuri Yamagata +6 more
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Tumor metastasis to bone [PDF]
Arthritis Research & Therapy, 2007 Establishment of skeletal metastasis involves bidirectional interactions between the tumor cell and the cellular elements in the bone microenvironment. A better understanding of the pathophysiology of bone metastasis will be critical in developing the means to prevent bone metastasis or inhibit its progression.
Virk, Mandeep S, Lieberman, Jay R
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Trends in Bone Metastasis Modeling [PDF]
Cancers, 2020 Bone is one of the most common sites for cancer metastasis. Bone tissue is composed by different kinds of cells that coexist in a coordinated balance. Due to the complexity of bone, it is impossible to capture the intricate interactions between cells under either physiological or pathological conditions.
Laranga R. +5 more
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Hallmarks of Bone Metastasis [PDF]
Calcified Tissue International, 2017 Breast cancer bone metastasis develops as the result of a series of complex interactions between tumor cells, bone marrow cells, and resident bone cells. The net effect of these interactions are the disruption of normal bone homeostasis, often with significantly increased osteoclast and osteoblast activity, which has provided a rational target for ...
Rachelle W. Johnson, Larry J. Suva
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Cancer Cell International, 2021 Background Bone is the most common site of metastatic breast cancer, and it is a leading cause of breast cancer-related death. This study aimed to explore bone metastasis-related long non-coding RNAs (lncRNAs) in breast cancer. Methods Four mRNA datasets
Yu Zhang +6 more
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