Results 41 to 50 of about 264,729 (304)

Management of patients with metastasis to the vertebrae: recommendations from the Italian Orthopaedic Society (SIOT) Bone Metastasis Study Group

, 2014
The purpose of this article is to outline the current approach to patients affected by metastasis to the spine and to present a clinical and surgical algorithm available for clinicians and for future research.
Casadei, Roberto, Spinelli, Maria Silvia, Capanna, Rodolfo, Boriani, Stefano, Papapietro, Nicola, The Italian Orthopaedic Society Bone Metastasis Study Group, Gasbarrini, Alessandro, Piccioli, Andrea, Di martino, Alberto   +8 more
core   +1 more source

Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer [PDF]

, 2020
Metastasis is the leading cause of cancer-related death. This multistage process involves contribution from both tumour cells and the tumour stroma to release metastatic cells into the circulation.
Taylor, T, J., Jeys, L., Bigger, B., Coonar, A., Alzabin, S., Fraser, D, W., Reekie, T., Finegan, G, F., Eyre, H., Babur, M., Williams, K., Singh, A., McMahon, A., Green, D., Chu, J., Rassl, D., Kassiou, M., Sumathi, V., Ponthan, F., Forster, D., Dalmay, T.   +20 more
core   +1 more source

Relationship of Tumor Markers and Hilar Lymph Nodes with Bone Metastasis of Whole Body Bone Imaging in Lung Adenocarcinoma

Zhongliu Fangzhi Yanjiu, 2019
Objective To investigate the relationship between tumor markers of lung cancer and bone metastasis of whole body bone imaging in lung adenocarcinoma. Methods The whole body bone imaging of 278 patients diagnosed as lung adenocarcinoma in our hospital was
CAO Zhongnian, ZHENG Rong, WEI Zhengmao, HONG Hao, GUAN Zhimei, LI Yuhuan   +5 more
doaj   +1 more source

MAZ promotes prostate cancer bone metastasis through transcriptionally activating the KRas-dependent RalGEFs pathway

Journal of Experimental & Clinical Cancer Research, 2019
Background Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. Myc-associated zinc-finger protein (MAZ) is a well-documented oncogene involved in the progression and metastasis of multiple cancer types, even in PCa. However,
Qing Yang, Chuandong Lang, Zhengquan Wu, Yuhu Dai, Shaofu He, Wei Guo, Shuai Huang, Hong Du, Dong Ren, Xinsheng Peng   +9 more
doaj   +1 more source

Overall Survival Improvement in Patients with Epidermal Growth Factor Receptor-Mutated Non-Small Cell Lung Cancer and Bone Metastasis Treated with Denosumab

, 2022
SIMPLE SUMMARY: Denosumab, a bone-modifying agent, has been approved for the prevention of or reduction in skeletal-related events (SREs) in non-small cell lung cancer (NSCLC) patients with bone metastasis. However, the effect of denosumab on survival of
Yang, Cheng-Ta, Chih-Teng Yu, Muh-Hwa Yang, Ko, How-Wen, Yu, Chih-Teng, Wang, Chih-Liang, Chi-Tsun Chiu, Wang, Chin-Chou, Tseng, Li-Chuan, Yang, Tsung-Ying, How-Wen Ko, Kuo, Chih-Hsi Scott, Chin-Chou Wang, Chien-Ying Liu, Chih-Hsi Scott Kuo, Cheng-Ta Yang, Li-Chuan Tseng, Yang, Muh-Hwa, Chiu, Chi-Tsun, Tsung-Ying Yang, Liu, Chien-Ying, Chih-Liang Wang   +21 more
core   +1 more source

Bone Metastasis From Gastric Adenocarcinoma—What Are the Risk Factors and Associated Survival? A Large Comprehensive Population-Based Cohort Study

Frontiers in Oncology, 2022
BackgroundWhile bone metastasis is not common in gastric adenocarcinoma (GaC), it can have important impacts on prognosis. This large cohort study aimed at exploring factors associated with bone metastasis in GaC and investigating the time-dependent ...
Lei Huang, Yajie Zhao, Yajie Zhao, Yan Shi, Weiguo Hu, Weiguo Hu, Jun Zhang, Jun Zhang   +7 more
doaj   +1 more source

Management of long bone metastases: recommendations from the Italian Orthopaedic Society bone metastasis study group

, 2014
The purpose of this article is to outline the current approach to patients affected by metastasis to the long bones and to present a clinical and surgical algorithm available for clinicians and for future research.
Gasbarrini Alessandro, CAPANNA, RODOLFO, Piana Raimondo, Gasbarrini A., Maccauro G., RUGGIERI, PIETRO, Piana R., Piccioli A., Piccioli Andrea, Spinelli M. S., Di Martino Alberto, Maccauro Giulio, Ippolito V., Ippolito Vincenzo, Di Martino A., The Italian Orthopaedic Society Bone Metastasis Study Group, Daolio P. A., Campanacci D. A., Ruggieri Pietro, Campanacci Domenico Andrea, Capanna R., Spinelli Maria Silvia, Daolio Primo Andrea   +22 more
core   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Restoring Tissue Homeostasis at Metastatic Sites: A Focus on Extracellular Vesicles in Bone Metastasis

Frontiers in Oncology, 2021
Bone is the most common site of cancer metastasis and the spread of cancer cells to the bone is associated with poor prognosis, pain, increased risk of fractures, and hypercalcemia.
Domenica Giannandrea, Valentina Citro, Elena Lesma, Monica Bignotto, Natalia Platonova, Raffaella Chiaramonte   +5 more
doaj   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source