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Prostate Cancer Bone Metastasis: Molecular Mechanisms of Tumor and Bone Microenvironment [PDF]
Cancer Management and ResearchHua Jiang Department of Urology, Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai Sixth People’s Hospital), Zhuhai, People’s Republic of ChinaCorrespondence: Hua Jiang, The Fifth Affiliated Hospital of Zunyi Medical University (Zhuhai Sixth ...
Hua Jiang
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Microenvironment-targeted strategy steers advanced bone regeneration
Materials Today Bio, 2023 Treatment of large bone defects represents a great challenge in orthopedic and craniomaxillofacial surgery. Traditional strategies in bone tissue engineering have focused primarily on mimicking the extracellular matrix (ECM) of bone in terms of structure
Jiacan Su, Yingying Jing, Mingkai Wang
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Pathological Crosstalk between Metastatic Breast Cancer Cells and the Bone Microenvironment
Biomolecules, 2020 Bone is the most common metastatic site in breast cancer. Upon arrival to the bone, disseminated tumor cells can undergo a period of dormancy but often eventually grow and hijack the bone microenvironment.
Daniel J Smit +2 more
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Bioactive MaterialsUsing bone tissue engineering strategies to achieve bone defect repair is a promising modality. However, the repair process outcomes are often unsatisfactory.
Peibiao Zhang, Dianwei Wang, Songjia Sun
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Bioactive Materials, 2023 Large bone defects resulting from fractures and disease are a major clinical challenge, being often unable to heal spontaneously by the body's repair mechanisms.
Qing Jiang, Siyu Shen, Yangyufan Wang
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The role and mechanisms of bone microenvironment regulators in osteoporosis: novel intervention strategies for addressing the challenges of aging [PDF]
Frontiers in EndocrinologyOsteoporosis is an increasingly important global health concern, particularly in aging populations, with prevalence rising markedly after the age of 60.
Hongyuan Yao +6 more
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Frontiers in Cell and Developmental Biology, 2023 Osteosarcoma is a primary bone tumor with a high mortality rate. The event-free survival rate has not improved significantly in the past 30 years, which brings a heavy burden to patients and society.
Jin Zeng +5 more
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Engineered Regeneration, 2022 Bone is a complex biological tissue with a complicated hierarchical nanocomposite structure. The native microenvironment of the bone tissue may be significantly disrupted by large physiological and pathological bone defects.
Pei Wang, Xiansong Wang
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Exercise improves subchondral bone microenvironment through regulating bone-cartilage crosstalk
Frontiers in Endocrinology, 2023 Articular cartilage degeneration has been proved to cause a variety of joint diseases, among which osteoarthritis is the most typical. Osteoarthritis is characterized by articular cartilage degeneration and persistent pain, which affects the quality of ...
Shihua Zhang +9 more
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Bone Research, 2022 Bone metastases occur in patients with advanced-stage prostate cancer (PCa). The cell-cell interaction between PCa and the bone microenvironment forms a vicious cycle that modulates the bone microenvironment, increases bone deformities, and drives tumor ...
Jawed Akhtar Siddiqui +12 more
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