Results 1 to 10 of about 81,648 (311)
Osteoclasts and Microgravity [PDF]
Life, 2020 Astronauts are at risk of losing 1.0% to 1.5% of their bone mass for every month they spend in space despite their adherence to diets and exercise regimens designed to protect their musculoskeletal systems. This loss is the result of microgravity-related
John Kelly Smith
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INTRAVASCULAR OSTEOCLASTS [PDF]
The Journal of Bone and Joint Surgery. British volume, 1957 1. In five out of eleven cases of osteoclastoma it was found that osteoclasts were present inside clearly defined blood vessels either within the tumours or in the tissues immediately surrounding the tumours.
R. A. Sladden
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Osteoclasts in Multiple Myeloma Are Derived from Gr-1+CD11b+Myeloid-Derived Suppressor Cells [PDF]
PLoS ONE, 2012 Osteoclasts play a key role in the development of cancer-associated osteolytic lesions. The number and activity of osteoclasts are often enhanced by tumors. However, the origin of osteoclasts is unknown.
Junling Zhuang +2 more
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Isolation and generation of osteoclasts
, 2019 This chapter describes the isolation, culture, and staining of osteoclasts. The key advantages of this assay are that it allows direct measurement of osteoclast number, bone resorption, as well as yielding good quantities of osteoclasts at defined ...
Alberta Zallone, Nadia Rucci, Anna Teti
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USP8-mediated mitochondrial regulation in osteoclasts is essential for skeletal development [PDF]
Cellular and Molecular Life SciencesAberrant protein regulatory pathways disrupt bone development and contribute to skeletal diseases. The cysteine protease family of deubiquitinating enzymes (DUBs) are critical for regulation of bone-resorbing osteoclasts and bone-forming osteoblasts ...
Sachin Chaugule +4 more
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Zoledronic acid promotes osteoclasts ferroptosis by inhibiting FBXO9-mediated p53 ubiquitination and degradation [PDF]
PeerJ, 2021 Bisphosphonates (BPs)-related osteonecrosis of jaw (BRONJ) is a severe complication of the long-term administration of BPs. The development of BRONJ is associated with the cell death of osteoclasts, but the underlying mechanism remains unclear.
Xingzhou Qu +3 more
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Inhibitory Effects of Gold and Silver Nanoparticles on the Differentiation into Osteoclasts In Vitro
Pharmaceutics, 2021 Gold nanoparticles (GNPs) have been widely studied to inhibit differentiation into osteoclasts. However, reports of the inhibitory effects of silver nanoparticles (SNPs) during the process of differentiation into osteoclasts are rare.
Daye Lee +6 more
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This is not an osteoclast [PDF]
Blood, 2016 ![Figure][1] A 64-year-old man with immunoglobulin A κ multiple myeloma was treated initially with bortezomib, thalidomide, dexamethasone, and daratumumab, an anti-CD38 antibody. After 4 cycles, the monoclonal component had decreased from 27 g/L to 8 g/L.
Adriana Plesa, Pierre Sujobert
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A New Method to Sort Differentiating Osteoclasts into Defined Homogeneous Subgroups
Cells, 2022 Osteoclasts regulate skeletal development but also drive pathological osteolysis, making them prime therapeutic targets. Osteoclast research is limited by the heterogeneity of osteoclast populations generated in vitro, where the mixture of ...
Philippa A. Hulley, Helen J. Knowles
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Immunological Medicine, 2022 Rheumatoid arthritis is a chronic form of arthritis that causes bone destruction in joints such as the knees and fingers. Over the past two decades, the clinical outcomes of rheumatoid arthritis have improved substantially with the development of ...
Tomoya Agemura +4 more
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