Results 1 to 10 of about 87,141 (298)
Osteoclasts and Microgravity [PDF]
Life, 2020 Astronauts are at risk of losing 1.0% to 1.5% of their bone mass for every month they spend in space despite their adherence to diets and exercise regimens designed to protect their musculoskeletal systems. This loss is the result of microgravity-related
John Kelly Smith
exaly +7 more sources
INTRAVASCULAR OSTEOCLASTS [PDF]
The Journal of Bone and Joint Surgery. British volume, 1957 1. In five out of eleven cases of osteoclastoma it was found that osteoclasts were present inside clearly defined blood vessels either within the tumours or in the tissues immediately surrounding the tumours. In two further cases it was found that osteoclasts protruded into the vessels although they were not lying free within the vessels. 2.
R. A. Sladden
openaire +3 more sources
Osteoclasts in Multiple Myeloma Are Derived from Gr-1+CD11b+Myeloid-Derived Suppressor Cells [PDF]
PLoS ONE, 2012 Osteoclasts play a key role in the development of cancer-associated osteolytic lesions. The number and activity of osteoclasts are often enhanced by tumors. However, the origin of osteoclasts is unknown.
James Edwards +2 more
exaly +2 more sources
Isolation and Generation of Osteoclasts
, 2019 This chapter describes the isolation, culture, and staining of osteoclasts. The key advantages of this assay are that it allows direct measurement of osteoclast number, bone resorption, as well as yielding good quantities of osteoclasts at defined stages of formation for molecular analysis.
Nadia Rucci, Alberta Zallone, Anna Teti
openaire +3 more sources
Effect of Urocortin on human osteoclasts differentiation
, 2018 : Introduction Osteoarthritis (OA) is a degenerative joint disease characterised by articular cartilage and subchondral bone degradation, which affects approximately eight million people in the UK only.
De Pascale, C. +2 more
core +6 more sources
Zoledronic acid promotes osteoclasts ferroptosis by inhibiting FBXO9-mediated p53 ubiquitination and degradation [PDF]
PeerJ, 2021 Bisphosphonates (BPs)-related osteonecrosis of jaw (BRONJ) is a severe complication of the long-term administration of BPs. The development of BRONJ is associated with the cell death of osteoclasts, but the underlying mechanism remains unclear.
Xingzhou Qu +3 more
doaj +2 more sources
The IRE1-XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5-HT Dependent Endogenous Anti-Autophagy Mechanism. [PDF]
Adv Sci (Weinh)A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Yang P +14 more
europepmc +2 more sources
Inhibitory Effects of Gold and Silver Nanoparticles on the Differentiation into Osteoclasts In Vitro
Pharmaceutics, 2021 Gold nanoparticles (GNPs) have been widely studied to inhibit differentiation into osteoclasts. However, reports of the inhibitory effects of silver nanoparticles (SNPs) during the process of differentiation into osteoclasts are rare.
Daye Lee +6 more
doaj +1 more source
Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK-Binding Osteoclastogenic Factor. [PDF]
Adv Sci (Weinh)Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Park C +13 more
europepmc +2 more sources
A New Method to Sort Differentiating Osteoclasts into Defined Homogeneous Subgroups
Cells, 2022 Osteoclasts regulate skeletal development but also drive pathological osteolysis, making them prime therapeutic targets. Osteoclast research is limited by the heterogeneity of osteoclast populations generated in vitro, where the mixture of ...
Philippa A. Hulley, Helen J. Knowles
doaj +1 more source