Results 1 to 10 of about 88,889 (259)
Osteoblast-Osteoclast Communication and Bone Homeostasis
Cells, 2020 Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell ...
Matthew B Greenblatt +2 more
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Zoledronic acid promotes osteoclasts ferroptosis by inhibiting FBXO9-mediated p53 ubiquitination and degradation [PDF]
PeerJ, 2021 Bisphosphonates (BPs)-related osteonecrosis of jaw (BRONJ) is a severe complication of the long-term administration of BPs. The development of BRONJ is associated with the cell death of osteoclasts, but the underlying mechanism remains unclear.
Xingzhou Qu +3 more
doaj +2 more sources
Inhibitory Effects of Gold and Silver Nanoparticles on the Differentiation into Osteoclasts In Vitro
Pharmaceutics, 2021 Gold nanoparticles (GNPs) have been widely studied to inhibit differentiation into osteoclasts. However, reports of the inhibitory effects of silver nanoparticles (SNPs) during the process of differentiation into osteoclasts are rare.
Daye Lee +6 more
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A New Method to Sort Differentiating Osteoclasts into Defined Homogeneous Subgroups
Cells, 2022 Osteoclasts regulate skeletal development but also drive pathological osteolysis, making them prime therapeutic targets. Osteoclast research is limited by the heterogeneity of osteoclast populations generated in vitro, where the mixture of ...
Philippa A. Hulley, Helen J. Knowles
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Immunological Medicine, 2022 Rheumatoid arthritis is a chronic form of arthritis that causes bone destruction in joints such as the knees and fingers. Over the past two decades, the clinical outcomes of rheumatoid arthritis have improved substantially with the development of ...
Tomoya Agemura +4 more
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Scientific Reports, 2021 Osteoclasts are multinucleated, bone-resorbing cells. However, they also digest cartilage during skeletal maintenance, development and in degradative conditions including osteoarthritis, rheumatoid arthritis and primary bone sarcoma.
Quitterie C. Larrouture +5 more
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Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro. [PDF]
PLoS ONE, 2012 Osteoclasts are the body's sole bone resorbing cells. Cytokines produced by pro-inflammatory effector T-cells (T(EFF)) increase bone resorption by osteoclasts.
Zachary S Buchwald +4 more
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Stem Cell Research & Therapy, 2020 Background Infantile malignant osteopetrosis (IMO) is an autosomal recessive disorder characterized by non-functional osteoclasts and a fatal outcome early in childhood. About 50% of patients have mutations in the TCIRG1 gene.
Xiaojie Xian +7 more
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Automated Quantification of Human Osteoclasts Using Object Detection
Frontiers in Cell and Developmental Biology, 2022 A balanced skeletal remodeling process is paramount to staying healthy. The remodeling process can be studied by analyzing osteoclasts differentiated in vitro from mononuclear cells isolated from peripheral blood or from buffy coats.
Sampsa Kohtala +9 more
doaj +1 more source
Centrosome clustering control in osteoclasts through CCR5-mediated signaling
Scientific Reports, 2023 Osteoclasts uniquely resorb calcified bone matrices. To exert their function, mature osteoclasts maintain the cellular polarity and directional vesicle trafficking to and from the resorbing bone surface.
Ji-Won Lee +10 more
doaj +1 more source