Results 11 to 20 of about 134,929 (355)
The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review
Frontiers in Immunology, 2023 The complicated connections and cross talk between the skeletal system and the immune system are attracting more attention, which is developing into the field of Osteoimmunology.
Jie Xu, +4 more
semanticscholar +1 more source
Inflammatory Osteoclasts Prime TNFα-Producing CD4+ T Cells and Express CX3CR1
Journal of Bone and Mineral Research, 2016 Matthieu Rouleau +2 more
exaly +2 more sources
PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis
Bone Research, 2022 Prostaglandin E2 (PGE2), a major cyclooxygenase-2 (COX-2) product, is highly secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis (OA) patients.
Wenhao Jiang +15 more
semanticscholar +1 more source
A New Method to Sort Differentiating Osteoclasts into Defined Homogeneous Subgroups
Cells, 2022 Osteoclasts regulate skeletal development but also drive pathological osteolysis, making them prime therapeutic targets. Osteoclast research is limited by the heterogeneity of osteoclast populations generated in vitro, where the mixture of ...
Philippa A. Hulley, Helen J. Knowles
doaj +1 more source
This is not an osteoclast [PDF]
Blood, 2016 ![Figure][1] A 64-year-old man with immunoglobulin A κ multiple myeloma was treated initially with bortezomib, thalidomide, dexamethasone, and daratumumab, an anti-CD38 antibody. After 4 cycles, the monoclonal component had decreased from 27 g/L to 8 g/L.
Adriana Plesa, Pierre Sujobert
openaire +2 more sources
Arthritis & Rheumatology, 2021 We have previously reported that stimulation of mouse bone marrow–derived macrophages with tumor necrosis factor (TNF) and interleukin‐6 (IL‐6) induces differentiation of osteoclast‐like cells.
K. Yokota +9 more
semanticscholar +1 more source
Immunological Medicine, 2022 Rheumatoid arthritis is a chronic form of arthritis that causes bone destruction in joints such as the knees and fingers. Over the past two decades, the clinical outcomes of rheumatoid arthritis have improved substantially with the development of ...
Tomoya Agemura +4 more
doaj +1 more source
Osteoclasts and Arthritis [PDF]
Journal of Bone and Mineral Research, 2009 INFLAMMATORY ARTHRITIS TYPICALLY presents as joint pain, swelling, and stiffness, which may be of short duration. For example, parvovirus B 19 infection, attended by painful polyarticular swelling, generally resolves spontaneously within 2 wk without joint destruction.
Georg, Schett, Steven L, Teitelbaum
openaire +3 more sources
Frontiers in Immunology, 2022 In response to mechanical forces and the aging process, bone in the adult skeleton is continuously remodeled by a process in which old and damaged bone is removed by bone-resorbing osteoclasts and subsequently is replaced by new bone by bone-forming ...
Tatjana Bordukalo-Nikšić +2 more
semanticscholar +1 more source
Origin of Osteoclasts: Osteoclast Precursor Cells
Journal of Bone Metabolism, 2023 Osteoclasts are multinucleated bone-resorbing cells and a key player in bone remodeling for health and disease. Since the discovery of osteoclasts in 1873, the structure and function of osteoclasts and the molecular and cellular mechanisms of osteoclastogenesis have been extensively studied.
Jefferson Tsai +4 more
openaire +2 more sources