Effect of Urocortin on human osteoclasts differentiation
, 2018 : Introduction Osteoarthritis (OA) is a degenerative joint disease characterised by articular cartilage and subchondral bone degradation, which affects approximately eight million people in the UK only.
De Pascale, C. +2 more
core +5 more sources
Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK-Binding Osteoclastogenic Factor. [PDF]
Adv Sci (Weinh)Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Park C +13 more
europepmc +2 more sources
The roles of osteoclasts and RUNX2 in the progression of prostate cancer bone metastases [PDF]
, 2021 Metastasis to the skeleton is the major cause of death from prostate cancer (PC). Patients with metastatic PC are treated with androgen deprivation therapy (ADT) to decrease testosterone levels and thereby inhibit further growth of the tumor.
Damber, Jan-Erik, +8 more
core +1 more source
Hormone-stimulated modulation of endocytic trafficking in osteoclasts [PDF]
, 2012 Copyright @ 2012 Stenbeck, Lawrence and Albert. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and ...
Stenbeck, G +11 more
core +1 more source
A novel assay for analysis of the regulation of the function of human osteoclasts. [PDF]
, 2006 BACKGROUND: Very little is known of the regulation of the function of human osteoclasts, largely due to the virtual impossibility of obtaining human osteoclasts ex vivo.
Shiroo Masahiro +17 more
core +1 more source
Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts.
PLoS ONE, 2011 CD68 is a member of the lysosome associated membrane protein (LAMP) family that is restricted in its expression to cells of the monocyte/macrophage lineage. This lineage restriction includes osteoclasts, and, while previous studies of CD68 in macrophages
Jason W Ashley +5 more
doaj +1 more source
The effect of brown algae (Sargassum sp.) gel on the number of osteoclasts in periodontitis rats
Padjadjaran Journal of Dentistry, 2022 Introduction: Alveolar bone resorption in periodontitis is caused by increased activation of osteoclasts, causing an imbalance of bone remodeling.
Muhamat Muhtar S. Abdurrohman +2 more
doaj +1 more source
Arthritis-associated osteoclastogenic macrophage, AtoM, as a key player in pathological bone erosion
Inflammation and Regeneration, 2022 Osteoclasts are myeloid lineage cells with a unique bone-destroying ability that maintains bone homeostasis together with bone formation by osteoblasts.
Tomoya Agemura +4 more
doaj +1 more source
Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling. [PDF]
PLoS ONE, 2008 Bone remodeling relies on the tightly regulated interplay between bone forming osteoblasts and bone digesting osteoclasts. Several studies have now described the molecular mechanisms by which osteoblasts control osteoclastogenesis and bone degradation ...
Maria Arantzazu Sanchez-Fernandez +4 more
doaj +1 more source
OC_Finder: Osteoclast Segmentation, Counting, and Classification Using Watershed and Deep Learning
Frontiers in Bioinformatics, 2022 Osteoclasts are multinucleated cells that exclusively resorb bone matrix proteins and minerals on the bone surface. They differentiate from monocyte/macrophage lineage cells in the presence of osteoclastogenic cytokines such as the receptor activator of ...
Xiao Wang +9 more
doaj +1 more source