Results 31 to 40 of about 134,929 (355)

Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts.

PLoS ONE, 2011
CD68 is a member of the lysosome associated membrane protein (LAMP) family that is restricted in its expression to cells of the monocyte/macrophage lineage. This lineage restriction includes osteoclasts, and, while previous studies of CD68 in macrophages
Jason W Ashley, Zhenqi Shi, Haibo Zhao, Xingsheng Li, Robert A Kesterson, Xu Feng   +5 more
doaj   +1 more source

OC_Finder: Osteoclast Segmentation, Counting, and Classification Using Watershed and Deep Learning

Frontiers in Bioinformatics, 2022
Osteoclasts are multinucleated cells that exclusively resorb bone matrix proteins and minerals on the bone surface. They differentiate from monocyte/macrophage lineage cells in the presence of osteoclastogenic cytokines such as the receptor activator of ...
Xiao Wang, Mizuho Kittaka, Mizuho Kittaka, Yilin He, Yiwei Zhang, Yasuyoshi Ueki, Yasuyoshi Ueki, Daisuke Kihara, Daisuke Kihara, Daisuke Kihara   +9 more
doaj   +1 more source

Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.

Developmental Cell, 2002
Signaling by RANKL is essential for terminal differentiation of monocytes/macrophages into osteoclasts. The TRAF6 and c-Fos signaling pathways both play important roles downstream of RANKL.
H. Takayanagi, Sunhwa Kim, T. Koga, H. Nishina, M. Isshiki, H. Yoshida, A. Saiura, M. Isobe, T. Yokochi, J. Inoue, E. Wagner, T. Mak, T. Kodama, T. Taniguchi   +13 more
semanticscholar   +1 more source

Arthritis-associated osteoclastogenic macrophage, AtoM, as a key player in pathological bone erosion

Inflammation and Regeneration, 2022
Osteoclasts are myeloid lineage cells with a unique bone-destroying ability that maintains bone homeostasis together with bone formation by osteoblasts.
Tomoya Agemura, Tetsuo Hasegawa, Shinya Yari, Junichi Kikuta, Masaru Ishii   +4 more
doaj   +1 more source

The M-CSF receptor in osteoclasts and beyond

Experimental and Molecular Medicine, 2020
Colony-stimulating factor 1 receptor (CSF1R, also known as c-FMS) is a receptor tyrosine kinase. Macrophage colony-stimulating factor (M-CSF) and IL-34 are ligands of CSF1R.
Sehwan Mun, P.S.U. Park, Kyung-Hyun Park-Min   +2 more
semanticscholar   +1 more source

The effect of brown algae (Sargassum sp.) gel on the number of osteoclasts in periodontitis rats

Padjadjaran Journal of Dentistry, 2022
Introduction: Alveolar bone resorption in periodontitis is caused by increased activation of osteoclasts, causing an imbalance of bone remodeling.
Muhamat Muhtar S. Abdurrohman, Rahmawati Sri Praptiningsih, Yulistinawati Yulistinawati   +2 more
doaj   +1 more source

Developmental origin, functional maintenance and genetic rescue of osteoclasts

Nature, 2019
Osteoclasts are multinucleated giant cells that resorb bone, ensuring development and continuous remodelling of the skeleton and the bone marrow haematopoietic niche.
Christian E. Jacome-Galarza, Gulce I Percin, James T. Muller, E. Mass, T. Lazarov, Jiri Eitler, M. Rauner, V. Yadav, L. Crozet, Mathieu Bohm, Pierre-Louis Loyher, G. Karsenty, Claudia Waskow, F. Geissmann   +13 more
semanticscholar   +1 more source

Erythromyeloid progenitors give rise to a population of osteoclasts contributing to bone homeostasis and repair

Nature Cell Biology, 2020
Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade bone. Here, we used lineage tracing studies—labelling cells expressing Cx3cr1, Csf1r or Flt3—to identify the precursors of osteoclasts in mice.
Yasuhito Yahara, T. Barrientos, Yuning J. Tang, V. Puviindran, Puviindran Nadesan, Hongyuan Zhang, Jason R. Gibson, S. Gregory, Yarui Diao, Yu Xiang, Y. Qadri, Tomokazu Souma, M. Shinohara, B. Alman   +13 more
semanticscholar   +1 more source

Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling. [PDF]

PLoS ONE, 2008
Bone remodeling relies on the tightly regulated interplay between bone forming osteoblasts and bone digesting osteoclasts. Several studies have now described the molecular mechanisms by which osteoblasts control osteoclastogenesis and bone degradation ...
Maria Arantzazu Sanchez-Fernandez, Anne Gallois, Thilo Riedl, Pierre Jurdic, Bernard Hoflack   +4 more
doaj   +1 more source

Fluid Flow-Induced Calcium Response in Osteoclasts: Signaling Pathways [PDF]

, 2014
Intracellular calcium oscillation and its downstream signaling in osteoclasts is believed to play critical roles in regulating bone resorption. Our previous study demonstrated that fluid shear stress (FSS) induced more calcium responsive peaks in the ...
Liu, Chenglin, Long, Mian, Li, Ping, Zhang, Ding, Zhang, D (reprint author), Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Stomatol,Fac Surg, Beijing 100730, Peoples R China., Hu, Man, Huo, Bo   +6 more
core   +1 more source