Results 31 to 40 of about 132,120 (348)

Break and then stand: novel insight into osteoclast functions in the skeletal system

Di-san junyi daxue xuebao, 2022
The skeleton provides the scaffold to support body weight, enable body movement, control mineral homeostasis, and provide the location for hematopoiesis.
DONG Shiwu, HU Wenhui
doaj   +1 more source

Activated γδ T cells inhibit osteoclast differentiation and resorptive activity in vitro [PDF]

, 2013
Peer reviewedPublisher ...
Pappalardo, A., Thompson, K.
core   +1 more source

Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures [PDF]

, 2014
The basic mechanisms by which strontium ranelate acts on bone are still unclear. We show that an important action of strontium salts is to block calcification in cultures of osteoblasts, the bone-forming cells.
A Barbara, A Caudrillier, AF Donneau, AS Hurtel-Lemaire, C Roux, D. P. Wornham, E Bonnelye, E Canalis, F Yang, FE McCaslin, G Boivin, GJ Atkins, GM Blake, HB Pan, I Schrooten, I Schrooten, I Schrooten, I. R. Orriss, IR Orriss, IR Orriss, IR Orriss, J Christoffersen, JJ Patel, JY Reginster, JY Reginster, M Grynpas, M Yamaguchi, M. O. Hajjawi, MA Karsdal, MS Rybchyn, N Chattopadhyay, N Takahashi, O Bruyere, O Fromigue, P Ammann, P Zioupos, PC D’Haese, PJ Marie, PJ Marie, PJ Marie, PJ Marie, PJ Meunier, SC Verberckmoes, SC Verberckmoes, T. R. Arnett   +44 more
core   +3 more sources

SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors. [PDF]

PLoS ONE, 2018
Bone remodeling occurs via coupling between bone resorption by osteoclasts and bone formation by osteoblasts. The mechanisms that regulate osteoclast signals to osteoblasts are not well understood.
Amy Tasca, Kristina Astleford, Nicholas C Blixt, Eric D Jensen, Rajaram Gopalakrishnan, Kim C Mansky   +5 more
doaj   +1 more source

The Beta-Tubulin Isotype TUBB6 Controls Microtubule and Actin Dynamics in Osteoclasts

Frontiers in Cell and Developmental Biology, 2021
Osteoclasts are bone resorbing cells that participate in the maintenance of bone health. Pathological increase in osteoclast activity causes bone loss, eventually resulting in osteoporosis.
Justine Maurin, Anne Morel, David Guérit, Julien Cau, Serge Urbach, Anne Blangy, Guillaume Bompard   +6 more
doaj   +1 more source

Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis [PDF]

, 2017
Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate ...
Fantauzzi, Claudia Blasetti, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe   +3 more
core   +2 more sources

Macrophages and osteoclasts: similarity and divergence between bone phagocytes

Frontiers in Immunology
Both macrophages and osteoclasts are vital immune components of the bone microenvironment. While macrophages play an essential role in phagocytosis, pathogen clearance and tissue remodeling, osteoclasts are well described for their bone resorption ...
Julia Halper, Bastien Dolfi, Stoyan Ivanov, Maria-Bernadette Madel, Claudine Blin-Wakkach   +4 more
doaj   +1 more source

The effects of seeding density and osteoclastic supplement concentration on osteoclastic differentiation and resorption

Bone Reports, 2023
The bone resorbing osteoclasts are a complex type of cell essential for in vivo bone remodeling. There is no consensus on medium composition and seeding density for in vitro osteoclastogenesis, despite the importance thereof on osteoclastic ...
Stefan J.A. Remmers, Freek C. van der Heijden, Keita Ito, Sandra Hofmann   +3 more
doaj   +1 more source

Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model

, 2011
In this paper we develop a lattice-based computational model focused on bone resorption by osteoclasts in a single cortical basic multicellular unit (BMU).
Anderson, Baron, Beysens, Block, Boyce, Boyde, Britz, Bronckers, Buenzli, Burger, Chambers, Civitelli, Cohen, Cooper, David W. Smith, Drasdo, Drasdo, Everts, Frost, Frost, Fukushima, García-Aznar, Gerlee, Ghaemi, Glauber, Glazier, Grynpas, Helfrich, Huang, Jaworski, Jeon, Junhwan Jeon, Manolagas, Mansury, Markus, Martin, Martin, Martin, Martin, Martin, Matsuoka, Miller, Mombach, Moshin, Nishiyama, Noble, Othmer, Othmer, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Pascal R. Buenzli, Peruani, Peter Pivonka, Peter T. Cummings, Poplawski, Robling, Roodman, Ryser, Schienbein, Schilling, Schweitzer, Stout, Susa, Tappen, van Kampen, van Oers, van Oers, Väänänen, Walker, Zhang   +74 more
core   +2 more sources

Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion

Biology, 2023
We previously demonstrated that mice with targeted deletion of the leucine repeat rich kinase 1 (Lrrk1) gene were osteopetrotic due to the failure of osteoclasts to resorb bone.
Sandi Shen, Mingjue Si, Canjun Zeng, Elaine K. Liu, Yian Chen, Jean Vacher, Haibo Zhao, Subburaman Mohan, Weirong Xing   +8 more
doaj   +1 more source