Results 31 to 40 of about 88,889 (259)

The effects of seeding density and osteoclastic supplement concentration on osteoclastic differentiation and resorption

Bone Reports, 2023
The bone resorbing osteoclasts are a complex type of cell essential for in vivo bone remodeling. There is no consensus on medium composition and seeding density for in vitro osteoclastogenesis, despite the importance thereof on osteoclastic ...
Stefan J.A. Remmers, Freek C. van der Heijden, Keita Ito, Sandra Hofmann   +3 more
doaj   +1 more source

Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion

Biology, 2023
We previously demonstrated that mice with targeted deletion of the leucine repeat rich kinase 1 (Lrrk1) gene were osteopetrotic due to the failure of osteoclasts to resorb bone.
Sandi Shen, Mingjue Si, Canjun Zeng, Elaine K. Liu, Yian Chen, Jean Vacher, Haibo Zhao, Subburaman Mohan, Weirong Xing   +8 more
doaj   +1 more source

Regulation of Osteoclast Differentiation by Myosin X

Scientific Reports, 2017
Osteoclasts begin as mononuclear cells that fuse to form multinuclear cells able to resorb bone. The mechanisms that regulate all the steps of osteoclast differentiation are not entirely known.
Amy Tasca, Kristina Astleford, Ari Lederman, Eric D. Jensen, Beth S. Lee, Rajaram Gopalakrishnan, Kim C. Mansky   +6 more
doaj   +1 more source

Tumor Necrosis Factor-α Produced by Osteoclasts Might Induce Intractable Pain in a Rat Spinal Metastasis Model of Breast Cancer

Spine Surgery and Related Research, 2019
Introduction: Causes of pain due to spinal metastases have been insufficiently investigated. Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were the focus of this study.
Ai Mazaki, Sumihisa Orita, Kazuhide Inage, Miyako Suzuki, Kohki Abe, Yasuhiro Shiga, Masahiro Inoue, Masaki Norimoto, Tomotaka Umimura, Seiji Ohtori, Kazuyo Yamauchi   +10 more
doaj   +1 more source

THOC5 regulates human osteoclastogenesis

European Journal of Cell Biology, 2022
Osteoclasts are bone resorbing cells that are responsible for physiological and pathological bone resorption. Macrophage colony stimulating factor (M-CSF) binds to the M-CSF receptor (c-FMS) and plays a key role in the differentiation and survival of ...
Se Hwan Mun, Brian Oh, Min Joon Lee, Seyeon Bae, Young Yang, Kyung-Hyun Park-Min   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

Research progress in the differentiation and function of osteoclasts in the inflammatory microenvironment

Kouqiang hemian waike zazhi
Osteoclasts are bone-resorbing cells that play essential roles in both physiological bone remodeling and pathological bone resorption. Inflammation serves as a significant inducer of pathological bone resorption.
WANG Jin, WANG Yabing, SU Jiansheng
doaj   +1 more source

The role of osteoclasts in breast cancer bone metastasis [PDF]

, 2016
Breast cancer frequently metastasises to the skeleton, interfering with the normal bone remodelling process and inducing bone degradation. Bone degradation is caused by osteoclasts, the normal bone-resorbing cells.
Le Pape, F., Geoffrey Vargas, Clézardin, P., François Le Pape, Vargas, G., Philippe Clézardin   +5 more
core   +1 more source