Results 31 to 40 of about 81,648 (311)
Break and then stand: novel insight into osteoclast functions in the skeletal system
Di-san junyi daxue xuebao, 2022 The skeleton provides the scaffold to support body weight, enable body movement, control mineral homeostasis, and provide the location for hematopoiesis.
DONG Shiwu, HU Wenhui
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SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors. [PDF]
PLoS ONE, 2018 Bone remodeling occurs via coupling between bone resorption by osteoclasts and bone formation by osteoblasts. The mechanisms that regulate osteoclast signals to osteoblasts are not well understood.
Amy Tasca +5 more
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The Beta-Tubulin Isotype TUBB6 Controls Microtubule and Actin Dynamics in Osteoclasts
Frontiers in Cell and Developmental Biology, 2021 Osteoclasts are bone resorbing cells that participate in the maintenance of bone health. Pathological increase in osteoclast activity causes bone loss, eventually resulting in osteoporosis.
Justine Maurin +6 more
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Bone Reports, 2023 The bone resorbing osteoclasts are a complex type of cell essential for in vivo bone remodeling. There is no consensus on medium composition and seeding density for in vitro osteoclastogenesis, despite the importance thereof on osteoclastic ...
Stefan J.A. Remmers +3 more
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Macrophages and osteoclasts: similarity and divergence between bone phagocytes
Frontiers in ImmunologyBoth macrophages and osteoclasts are vital immune components of the bone microenvironment. While macrophages play an essential role in phagocytosis, pathogen clearance and tissue remodeling, osteoclasts are well described for their bone resorption ...
Julia Halper +4 more
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A novel assay for analysis of the regulation of the function of human osteoclasts.
, 2006 BACKGROUND: Very little is known of the regulation of the function of human osteoclasts, largely due to the virtual impossibility of obtaining human osteoclasts ex vivo.
Shiroo Masahiro +17 more
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Osteoclasts and hematopoiesis [PDF]
BoneKEy Reports, 2012 The skeletal tissue is closely associated with the hematopoietic tissue lodged in its inner cavities. Besides the well-known role of the endosteal osteoblasts in the maintenance of the hematopoietic stem cell (HSC) niche, it is an emerging concept that osteoclasts are involved in the regulation of hematopoiesis as well, although published data are ...
openaire +3 more sources
Biology, 2023 We previously demonstrated that mice with targeted deletion of the leucine repeat rich kinase 1 (Lrrk1) gene were osteopetrotic due to the failure of osteoclasts to resorb bone.
Sandi Shen +8 more
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Osteoclast Fusion and Fission [PDF]
Calcified Tissue International, 2012 Osteoclasts are specialized multinucleated cells with the unique capacity to resorb bone. Despite insight into the various steps of the interaction of osteoclast precursors leading to osteoclast formation, surprisingly little is known about what happens with the multinucleated cell itself after it has been formed.
Jansen, I.D.C. +4 more
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Kouqiang hemian waike zazhiOsteoclasts are bone-resorbing cells that play essential roles in both physiological bone remodeling and pathological bone resorption. Inflammation serves as a significant inducer of pathological bone resorption.
WANG Jin, WANG Yabing, SU Jiansheng
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