Results 41 to 50 of about 134,929 (355)
Frontiers in Cell and Developmental Biology, 2020 Tumor necrosis factor-alpha (TNF-α) promotes osteoclasts differentiation to enhance bone resorption and inhibits osteoblasts differentiation to impair bone formation, which plays a central role in the development of postmenopausal osteoporosis (PMOP ...
Zhuochao Liu +9 more
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Bone Research, 2018 The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on osteoblastogenesis, osteclastogenesis, and angiogenesis in a paracrine manner ...
Yujiao Han +4 more
semanticscholar +1 more source
Fluid flow-induced calcium response in early or late differentiated osteoclasts [PDF]
, 2012 Intracellular calcium oscillation caused by receptor activator of nuclear factor kappa-B ligand has been demonstrated to promote the differentiation of osteoclasts.
Gao YX(高宇欣) +9 more
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BMC Musculoskeletal Disorders, 2010 Background Bone resorption is initiated by osteoclastic acidification of the resorption lacunae. This process is mediated by secretion of protons through the V-ATPase and chloride through the chloride antiporter ClC-7.
Boutin Jean A +5 more
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Osteoclast Differentiation [PDF]
Critical Reviews in Oral Biology & Medicine, 1991 The osteoclast is the primary bone resorbing cell. It is a highly specialized multinucleated cell whose primary function is to help in the control of calcium homeostasis. The osteoclast has been very difficult to study because of its relative inaccessability, low numbers, and fragility when isolated from bone.
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Break and then stand: novel insight into osteoclast functions in the skeletal system
Di-san junyi daxue xuebao, 2022 The skeleton provides the scaffold to support body weight, enable body movement, control mineral homeostasis, and provide the location for hematopoiesis.
DONG Shiwu, HU Wenhui
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Effect of monoterpenes on the formation and activation of osteoclasts in vitro [PDF]
, 2006 Monoterpenes, present in aromatic plants, are known to inhibit bone resorption in vivo. In this in vitro study, they inhibited the activation of osteoclasts only at high concentrations but inhibited the formation at much lower concentrations.
Felix, Rolf +4 more
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Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain
Journal of Clinical Investigation, 2019 Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated subchondral bone remodeling in sensory innervation for OA pain.
Shouan Zhu +27 more
semanticscholar +1 more source
SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors. [PDF]
PLoS ONE, 2018 Bone remodeling occurs via coupling between bone resorption by osteoclasts and bone formation by osteoblasts. The mechanisms that regulate osteoclast signals to osteoblasts are not well understood.
Amy Tasca +5 more
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The Beta-Tubulin Isotype TUBB6 Controls Microtubule and Actin Dynamics in Osteoclasts
Frontiers in Cell and Developmental Biology, 2021 Osteoclasts are bone resorbing cells that participate in the maintenance of bone health. Pathological increase in osteoclast activity causes bone loss, eventually resulting in osteoporosis.
Justine Maurin +6 more
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