Results 41 to 50 of about 87,141 (298)

Osteoclast Fusion and Fission [PDF]

Calcified Tissue International, 2012
Osteoclasts are specialized multinucleated cells with the unique capacity to resorb bone. Despite insight into the various steps of the interaction of osteoclast precursors leading to osteoclast formation, surprisingly little is known about what happens with the multinucleated cell itself after it has been formed.
Jansen, I.D.C., Vermeer, J.A.F., Bloemen, V., Stap, J., Everts, V.   +4 more
openaire   +7 more sources

Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion

Biology, 2023
We previously demonstrated that mice with targeted deletion of the leucine repeat rich kinase 1 (Lrrk1) gene were osteopetrotic due to the failure of osteoclasts to resorb bone.
Sandi Shen, Mingjue Si, Canjun Zeng, Elaine K. Liu, Yian Chen, Jean Vacher, Haibo Zhao, Subburaman Mohan, Weirong Xing   +8 more
doaj   +1 more source

The Origin of Osteoclasts

Immunobiology, 1982
We are satisfied from studies with mi mi osteopetrotic mutant mice that osteoclasts arise from the myeloid tissue of bone marrow and not as formerly proposed from osteoprogenitor cells. Grafts of compatible normal myeloid cells cure the osteopetrosis by the substitution of the qualitatively defective osteoclasts with normal ones.
J F, Loutit, N W, Nisbet
openaire   +2 more sources

Regulation of Osteoclast Differentiation by Myosin X

Scientific Reports, 2017
Osteoclasts begin as mononuclear cells that fuse to form multinuclear cells able to resorb bone. The mechanisms that regulate all the steps of osteoclast differentiation are not entirely known.
Amy Tasca, Kristina Astleford, Ari Lederman, Eric D. Jensen, Beth S. Lee, Rajaram Gopalakrishnan, Kim C. Mansky   +6 more
doaj   +1 more source

Tumor Necrosis Factor-α Produced by Osteoclasts Might Induce Intractable Pain in a Rat Spinal Metastasis Model of Breast Cancer

Spine Surgery and Related Research, 2019
Introduction: Causes of pain due to spinal metastases have been insufficiently investigated. Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were the focus of this study.
Ai Mazaki, Sumihisa Orita, Kazuhide Inage, Miyako Suzuki, Kohki Abe, Yasuhiro Shiga, Masahiro Inoue, Masaki Norimoto, Tomotaka Umimura, Seiji Ohtori, Kazuyo Yamauchi   +10 more
doaj   +1 more source

THOC5 regulates human osteoclastogenesis

European Journal of Cell Biology, 2022
Osteoclasts are bone resorbing cells that are responsible for physiological and pathological bone resorption. Macrophage colony stimulating factor (M-CSF) binds to the M-CSF receptor (c-FMS) and plays a key role in the differentiation and survival of ...
Se Hwan Mun, Brian Oh, Min Joon Lee, Seyeon Bae, Young Yang, Kyung-Hyun Park-Min   +5 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

Advanced Science, EarlyView.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke, Poh Soo Lee   +10 more
wiley   +1 more source

Preventive CCL2/CCR2 Axis Blockade Suppresses Osteoclast Activity in a Mouse Model of Rheumatoid Arthritis by Reducing Homing of CCR2hi Osteoclast Progenitors to the Affected Bone

Frontiers in Immunology, 2021
Detailed characterization of medullary and extramedullary reservoirs of osteoclast progenitors (OCPs) is required to understand the pathophysiology of increased periarticular and systemic bone resorption in arthritis.
Darja Flegar, Darja Flegar, Maša Filipović, Maša Filipović, Alan Šućur, Alan Šućur, Antonio Markotić, Antonio Markotić, Nina Lukač, Nina Lukač, Dino Šisl, Dino Šisl, Marina Ikić Matijašević, Zrinka Jajić, Tomislav Kelava, Tomislav Kelava, Vedran Katavić, Vedran Katavić, Nataša Kovačić, Nataša Kovačić, Danka Grčević, Danka Grčević   +21 more
doaj   +1 more source

Optical Windows for Transcranial Brain Imaging in Living Mice: Skull Thinning, Clearing, and Beyond

Advanced Science, EarlyView.
Longitudinal, noninvasive in vivo imaging is crucial for studying brain physiology. Advances in transcranial optical windows and multiphoton microscopy have improved imaging depth, but their performance often deteriorates over time. This work investigated various transcranial window approaches and found that skull regrowth limits image quality.
Yiming Fu, Gewei Yan, Zhentao She, Yingzhu He, Kangqi Liu, Jianan Qu   +5 more
wiley   +1 more source