Results 21 to 30 of about 88,889 (259)

Screening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption

BMC Musculoskeletal Disorders, 2010
Background Bone resorption is initiated by osteoclastic acidification of the resorption lacunae. This process is mediated by secretion of protons through the V-ATPase and chloride through the chloride antiporter ClC-7.
Boutin Jean A, Dziegiel Morten H, Karsdal Morten A, Sørensen Mette G, Nosjean Olivier, Henriksen Kim   +5 more
doaj   +1 more source

CircHmbox1 Targeting miRNA-1247-5p Is Involved in the Regulation of Bone Metabolism by TNF-α in Postmenopausal Osteoporosis

Frontiers in Cell and Developmental Biology, 2020
Tumor necrosis factor-alpha (TNF-α) promotes osteoclasts differentiation to enhance bone resorption and inhibits osteoblasts differentiation to impair bone formation, which plays a central role in the development of postmenopausal osteoporosis (PMOP ...
Zhuochao Liu, Changwei Li, Ping Huang, Fangqiong Hu, Min Jiang, Xing Xu, Bin Li, Lianfu Deng, Tianwen Ye, Lei Guo   +9 more
doaj   +1 more source

Break and then stand: novel insight into osteoclast functions in the skeletal system

Di-san junyi daxue xuebao, 2022
The skeleton provides the scaffold to support body weight, enable body movement, control mineral homeostasis, and provide the location for hematopoiesis.
DONG Shiwu, HU Wenhui
doaj   +1 more source

Fluid Flow-Induced Calcium Response in Osteoclasts: Signaling Pathways [PDF]

, 2014
Intracellular calcium oscillation and its downstream signaling in osteoclasts is believed to play critical roles in regulating bone resorption. Our previous study demonstrated that fluid shear stress (FSS) induced more calcium responsive peaks in the ...
Liu, Chenglin, Long, Mian, Li, Ping, Zhang, Ding, Zhang, D (reprint author), Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Stomatol,Fac Surg, Beijing 100730, Peoples R China., Hu, Man, Huo, Bo   +6 more
core   +1 more source

Fluid flow-induced calcium response in early or late differentiated osteoclasts [PDF]

, 2012
Intracellular calcium oscillation caused by receptor activator of nuclear factor kappa-B ligand has been demonstrated to promote the differentiation of osteoclasts.
Gao YX(高宇欣), Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Key Lab Micrograv, 15 N 4th Ring Rd, Beijing 100190, Peoples R China., Li P(李平), Long M(龙勉), Zhang D, Sun SJ(孙树津), Hu M(胡漫), Huo, B, Zhang Y(章燕), Huo B(霍波)   +9 more
core   +1 more source

Osteoclasts and Microgravity

Life, 2020
Astronauts are at risk of losing 1.0% to 1.5% of their bone mass for every month they spend in space despite their adherence to diets and exercise regimens designed to protect their musculoskeletal systems. This loss is the result of microgravity-related
John Kelly Smith
doaj   +1 more source

Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cells. [PDF]

PLoS ONE, 2012
Osteoclasts play a key role in the development of cancer-associated osteolytic lesions. The number and activity of osteoclasts are often enhanced by tumors. However, the origin of osteoclasts is unknown.
Junling Zhuang, Jianghong Zhang, Seint T Lwin, James R Edwards, Claire M Edwards, Gregory R Mundy, Xiangli Yang   +6 more
doaj   +1 more source

SMAD1/5 signaling in osteoclasts regulates bone formation via coupling factors. [PDF]

PLoS ONE, 2018
Bone remodeling occurs via coupling between bone resorption by osteoclasts and bone formation by osteoblasts. The mechanisms that regulate osteoclast signals to osteoblasts are not well understood.
Amy Tasca, Kristina Astleford, Nicholas C Blixt, Eric D Jensen, Rajaram Gopalakrishnan, Kim C Mansky   +5 more
doaj   +1 more source

The Beta-Tubulin Isotype TUBB6 Controls Microtubule and Actin Dynamics in Osteoclasts

Frontiers in Cell and Developmental Biology, 2021
Osteoclasts are bone resorbing cells that participate in the maintenance of bone health. Pathological increase in osteoclast activity causes bone loss, eventually resulting in osteoporosis.
Justine Maurin, Anne Morel, David Guérit, Julien Cau, Serge Urbach, Anne Blangy, Guillaume Bompard   +6 more
doaj   +1 more source

Macrophages and osteoclasts: similarity and divergence between bone phagocytes

Frontiers in Immunology
Both macrophages and osteoclasts are vital immune components of the bone microenvironment. While macrophages play an essential role in phagocytosis, pathogen clearance and tissue remodeling, osteoclasts are well described for their bone resorption ...
Julia Halper, Bastien Dolfi, Stoyan Ivanov, Maria-Bernadette Madel, Claudine Blin-Wakkach   +4 more
doaj   +1 more source