Results 21 to 30 of about 134,929 (355)

The roles of osteoclasts and RUNX2 in the progression of prostate cancer bone metastases [PDF]

, 2021
Metastasis to the skeleton is the major cause of death from prostate cancer (PC). Patients with metastatic PC are treated with androgen deprivation therapy (ADT) to decrease testosterone levels and thereby inhibit further growth of the tumor.
Huang, Junchi
core   +1 more source

Loss of mutual protection between human osteoclasts and chondrocytes in damaged joints initiates osteoclast-mediated cartilage degradation by MMPs

Scientific Reports, 2021
Osteoclasts are multinucleated, bone-resorbing cells. However, they also digest cartilage during skeletal maintenance, development and in degradative conditions including osteoarthritis, rheumatoid arthritis and primary bone sarcoma.
Quitterie C. Larrouture, Adam P. Cribbs, Srinivasa R. Rao, Martin Philpott, Sarah J. Snelling, Helen J. Knowles   +5 more
doaj   +1 more source

The origins and roles of osteoclasts in bone development, homeostasis and repair.

Development, 2022
The mechanisms underlying bone development, repair and regeneration are reliant on the interplay and communication between osteoclasts and other surrounding cells.
Yasuhito Yahara, Tuyet Nguyen, K. Ishikawa, Katsuhiko Kamei, B. Alman   +4 more
semanticscholar   +1 more source

Generation of gene-corrected functional osteoclasts from osteopetrotic induced pluripotent stem cells

Stem Cell Research & Therapy, 2020
Background Infantile malignant osteopetrosis (IMO) is an autosomal recessive disorder characterized by non-functional osteoclasts and a fatal outcome early in childhood. About 50% of patients have mutations in the TCIRG1 gene.
Xiaojie Xian, Roksana Moraghebi, Henrik Löfvall, Anders Fasth, Kim Henriksen, Johan Richter, Niels-Bjarne Woods, Ilana Moscatelli   +7 more
doaj   +1 more source

Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro. [PDF]

PLoS ONE, 2012
Osteoclasts are the body's sole bone resorbing cells. Cytokines produced by pro-inflammatory effector T-cells (T(EFF)) increase bone resorption by osteoclasts.
Zachary S Buchwald, Jennifer R Kiesel, Richard DiPaolo, Meghana S Pagadala, Rajeev Aurora   +4 more
doaj   +1 more source

Automated Quantification of Human Osteoclasts Using Object Detection

Frontiers in Cell and Developmental Biology, 2022
A balanced skeletal remodeling process is paramount to staying healthy. The remodeling process can be studied by analyzing osteoclasts differentiated in vitro from mononuclear cells isolated from peripheral blood or from buffy coats.
Sampsa Kohtala, Tonje Marie Vikene Nedal, Carlo Kriesi, Carlo Kriesi, Siv Helen Moen, Qianli Ma, Kristin Sirnes Ødegaard, Therese Standal, Therese Standal, Martin Steinert   +9 more
doaj   +1 more source

Osteoblast-Osteoclast Communication and Bone Homeostasis

Cells, 2020
Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell ...
Jung-Min Kim, Chujiao Lin, Zheni Stavre, Matthew B. Greenblatt, Jae-Hyuck Shim   +4 more
doaj   +1 more source

Centrosome clustering control in osteoclasts through CCR5-mediated signaling

Scientific Reports, 2023
Osteoclasts uniquely resorb calcified bone matrices. To exert their function, mature osteoclasts maintain the cellular polarity and directional vesicle trafficking to and from the resorbing bone surface.
Ji-Won Lee, In-Hee Lee, Haruhisa Watanabe, Yunqing Liu, Kazuaki Sawada, Masashi Maekawa, Shunsuke Uehara, Yasuhiro Kobayashi, Yuuki Imai, Sek Won Kong, Tadahiro Iimura   +10 more
doaj   +1 more source

Hormone-stimulated modulation of endocytic trafficking in osteoclasts [PDF]

, 2012
Copyright @ 2012 Stenbeck, Lawrence and Albert. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and ...
Stenbeck, G, Anthony P. Albert, Albert, Anthony P., Lawrence, Kevin M., Lawrence, KM, Kevin M. Lawrence, Gudrun eStenbeck, Stenbeck, Gudrun, Anthony P Albert, Gudrun Stenbeck, Albert, AP, Kevin M Lawrence   +11 more
core   +1 more source

A novel assay for analysis of the regulation of the function of human osteoclasts. [PDF]

, 2006
BACKGROUND: Very little is known of the regulation of the function of human osteoclasts, largely due to the virtual impossibility of obtaining human osteoclasts ex vivo.
Shiroo Masahiro, Samuelsson, B, Kirstein Barrie, Chambers, TJ, Barrie Kirstein, Shiroo, M, Fuller, K, Urszula Grabowska, Karen Fuller, Grabowska Urszula, Masahiro Shiroo, Grabowska, U, Samuelsson Bertil, Chambers Timothy J, Fuller Karen, Bertil Samuelsson, Timothy J Chambers, Kirstein, B   +17 more
core   +1 more source