Results 21 to 30 of about 81,648 (311)
Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts.
PLoS ONE, 2011 CD68 is a member of the lysosome associated membrane protein (LAMP) family that is restricted in its expression to cells of the monocyte/macrophage lineage. This lineage restriction includes osteoclasts, and, while previous studies of CD68 in macrophages
Jason W Ashley +5 more
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OC_Finder: Osteoclast Segmentation, Counting, and Classification Using Watershed and Deep Learning
Frontiers in Bioinformatics, 2022 Osteoclasts are multinucleated cells that exclusively resorb bone matrix proteins and minerals on the bone surface. They differentiate from monocyte/macrophage lineage cells in the presence of osteoclastogenic cytokines such as the receptor activator of ...
Xiao Wang +9 more
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Arthritis-associated osteoclastogenic macrophage, AtoM, as a key player in pathological bone erosion
Inflammation and Regeneration, 2022 Osteoclasts are myeloid lineage cells with a unique bone-destroying ability that maintains bone homeostasis together with bone formation by osteoblasts.
Tomoya Agemura +4 more
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The effect of brown algae (Sargassum sp.) gel on the number of osteoclasts in periodontitis rats
Padjadjaran Journal of Dentistry, 2022 Introduction: Alveolar bone resorption in periodontitis is caused by increased activation of osteoclasts, causing an imbalance of bone remodeling.
Muhamat Muhtar S. Abdurrohman +2 more
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Osteoclasts control osteoblast chemotaxis via PDGF-BB/PDGF receptor beta signaling. [PDF]
PLoS ONE, 2008 Bone remodeling relies on the tightly regulated interplay between bone forming osteoblasts and bone digesting osteoclasts. Several studies have now described the molecular mechanisms by which osteoblasts control osteoclastogenesis and bone degradation ...
Maria Arantzazu Sanchez-Fernandez +4 more
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Advances in the Regulation of Osteoclasts and Osteoclast Functions [PDF]
Journal of Dental Research, 2013 Osteoclasts are derived from mononuclear hematopoietic myeloid lineage cells, which are formed in the bone marrow and are attracted to the bloodstream by factors, including sphingsine-1 phosphate. These circulating precursors are attracted to bone surfaces undergoing resorption by chemokines and other factors expressed at these sites, where they fuse ...
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Frontiers in Cell and Developmental Biology, 2020 Tumor necrosis factor-alpha (TNF-α) promotes osteoclasts differentiation to enhance bone resorption and inhibits osteoblasts differentiation to impair bone formation, which plays a central role in the development of postmenopausal osteoporosis (PMOP ...
Zhuochao Liu +9 more
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Fluid flow-induced calcium response in early or late differentiated osteoclasts [PDF]
, 2012 Intracellular calcium oscillation caused by receptor activator of nuclear factor kappa-B ligand has been demonstrated to promote the differentiation of osteoclasts.
Gao YX(高宇欣) +9 more
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Osteoclast Differentiation [PDF]
Critical Reviews in Oral Biology & Medicine, 1991 The osteoclast is the primary bone resorbing cell. It is a highly specialized multinucleated cell whose primary function is to help in the control of calcium homeostasis. The osteoclast has been very difficult to study because of its relative inaccessability, low numbers, and fragility when isolated from bone.
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BMC Musculoskeletal Disorders, 2010 Background Bone resorption is initiated by osteoclastic acidification of the resorption lacunae. This process is mediated by secretion of protons through the V-ATPase and chloride through the chloride antiporter ClC-7.
Boutin Jean A +5 more
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