Results 1 to 10 of about 38,030 (279)

Lipocalin-2 upregulation in hypoxic murine osteocytes enhances RANKL-induced osteoclastogenesis [PDF]

Scientific Reports
Osteocytes regulate bone remodeling by interacting with osteoblasts and osteoclasts. Hypoxia influences osteocyte function and has been linked to increased osteoclastogenesis in pathological conditions such as orthodontic tooth movement (OTM) and bone ...
Kohei Narita, Fumitoshi Ohori, Aseel Marahleh, Jinghan Ma, Jiayi Ren, Angyi Lin, Ziqiu Fan, Kou Murakami, Hideki Kitaura   +8 more
doaj   +2 more sources

Single-cell RNA sequencing identifies Fgf23-expressing osteocytes in response to 1,25-dihydroxyvitamin D3 treatment

Frontiers in Physiology, 2023
Fibroblast growth factor 23 (FGF23), a hormone, mainly produced by osteocytes, regulates phosphate and vitamin D metabolism. By contrast, 1,25-dihydroxyvitamin D3, the active form of vitamin D, has been shown to enhance FGF23 production.
Ayako Hanai, Ayako Hanai, Ayako Kawabata, Kenta Nakajima, Kazuhiro Masuda, Itaru Urakawa, Masahiro Abe, Yuji Yamazaki, Seiji Fukumoto   +8 more
doaj   +1 more source

Differential Expression of Dickkopf 1 and Periostin in Mouse Strains with High and Low Bone Mass

Biology, 2022
By expressing different genes and proteins that regulate osteoclast as well as osteoblast formation, osteocytes orchestrate bone metabolism. The aim of this project was the evaluation of the differences in the osteocytes’ secretory activity in the low ...
Katharina Kerschan-Schindl, Victoria Schramek, Maria Butylina, Ursula Föger-Samwald, Peter Pietschmann   +4 more
doaj   +1 more source

Effect of High Static Magnetic Fields on Biological Activities and Iron Metabolism in MLO-Y4 Osteocyte-like Cells

Cells, 2021
There are numerous studies that investigate the effects of static magnetic fields (SMFs) on osteoblasts and osteoclasts. However, although osteocytes are the most abundant cell type in bone tissue, there are few studies on the biological effects of ...
Jiancheng Yang, Gejing Zhang, Qingmei Li, Qinghua Tang, Yan Feng, Peng Shang, Yuhong Zeng   +6 more
doaj   +1 more source

Extracellular Fe2+ and Fe3+ modulate osteocytic viability, expression of SOST, RANKL and FGF23, and fluid flow-induced YAP1 nuclear translocation

Scientific Reports, 2023
Iron overload negatively affects bone mass and strength. However, the impact of iron excess on osteocytes—important bone cells for mechanotransduction and remodeling—is poorly understood.
Wasutorn Chankamngoen, Saowalak Krungchanuchat, Jirawan Thongbunchoo, Naraporn Sirinonthanawech, Jarinthorn Teerapornpuntakit, Nattapon Panupinthu, Narattaphol Charoenphandhu   +6 more
doaj   +1 more source

Overexpression of Lrp5 enhanced the anti-breast cancer effects of osteocytes in bone

Bone Research, 2021
Osteocytes are the most abundant cells in bone, which is a frequent site of breast cancer metastasis. Here, we focused on Wnt signaling and evaluated tumor-osteocyte interactions.
Shengzhi Liu, Di Wu, Xun Sun, Yao Fan, Rongrong Zha, Aydin Jalali, Yan Feng, Kexin Li, Tomohiko Sano, Nicole Vike, Fangjia Li, Joseph Rispoli, Akihiro Sudo, Jing Liu, Alexander Robling, Harikrishna Nakshatri, Bai-Yan Li, Hiroki Yokota   +17 more
doaj   +1 more source

Single cell cortical bone transcriptomics define novel osteolineage gene sets altered in chronic kidney disease

Frontiers in Endocrinology, 2023
IntroductionDue to a lack of spatial-temporal resolution at the single cell level, the etiologies of the bone dysfunction caused by diseases such as normal aging, osteoporosis, and the metabolic bone disease associated with chronic kidney disease (CKD ...
Rafiou Agoro, Intawat Nookaew, Megan L. Noonan, Yamil G. Marambio, Sheng Liu, Wennan Chang, Wennan Chang, Hongyu Gao, Hongyu Gao, Lainey M. Hibbard, Corinne E. Metzger, Daniel Horan, William R. Thompson, Xiaoling Xuei, Yunlong Liu, Yunlong Liu, Chi Zhang, Chi Zhang, Alexander G. Robling, Lynda F. Bonewald, Lynda F. Bonewald, Jun Wan, Kenneth E. White, Kenneth E. White   +23 more
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The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States

Frontiers in Cell and Developmental Biology, 2022
Bone homeostasis is a dynamic equilibrium between bone-forming osteoblasts and bone-resorbing osteoclasts. This process is primarily controlled by the most abundant and mechanosensitive bone cells, osteocytes, that reside individually, within chambers of
Jung Un Ally Choi, Amanda W. Kijas, Jan Lauko, Alan E. Rowan   +3 more
doaj   +1 more source

Osteocyte: a Cellular Basis for Mechanotransduction in Bone

Journal of Biomechanical Science and Engineering, 2007
Osteocyte is the most abundant cell type in bone, and the only cell type located inside the mineralized matrix. The striking structural design of bone predicts an important role for osteocytes in determining bone structure and function.
Guoliang GU, Kosaku KURATA, Zhi CHEN, Kalervo H. VÄÄNÄNEN   +3 more
doaj   +1 more source

CSF‐1 in Osteocytes Inhibits Nox4‐mediated Oxidative Stress and Promotes Normal Bone Homeostasis

JBMR Plus, 2020
CSF‐1 is a key factor in regulating bone remodeling; osteocytes express CSF‐1 and its receptor. Viable osteocytes are essential for bone remodeling through cell–cell contact and secretion of factors that regulate osteoblasts and osteoclasts.
Sherry L Werner, Ramaswamy Sharma, Kathleen Woodruff, Diane Horn, Stephen E Harris, Yves Gorin, Doug‐Yoon Lee, Rui Hua, Sumin Gu, Roberto J Fajardo, Samy L Habib, Jean X Jiang   +11 more
doaj   +1 more source