Results 31 to 40 of about 38,030 (279)

The myosin and RhoGAP MYO9B influences osteocyte dendrite growth and responses to mechanical stimuli

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Myosin IXB (MYO9B) is an unconventional myosin with RhoGAP activity and thus is a regulator of actin cytoskeletal organization. MYO9B was previously shown to be necessary for skeletal growth and health and to play a role in actin-based ...
Beth S. Lee, Cynthia Murray, Jie Liu, Minji Kim, Min Sik Hwang, Tina Yueh, Myrna Mansour, Sana Qamar, Gunjan Agarwal, Do-Gyoon Kim   +9 more
doaj   +1 more source

The ultrastructural relationship between osteocytes and dental implants following osseointegration [PDF]

, 2016
BackgroundOsteocytes, the most abundant cells in bone, have multiple functions, including acting as mechanosensors and regulating mineralization. It is clear that osteocytes influence bone remodeling by controlling the differentiation and activity of ...
Feng, Jian Q., Jian Q. Feng, Xiao, Yin, Zhibin Du, Stephen M. Hamlet, Hamlet, Stephen, Q. Feng, Jian, Du, Zhibin, Feng, Jian Q, Feng, Jian Quan, Yin Xiao, Hamlet, Stephen M., Saso Ivanovski, Hamlet, Stephen M, Ivanovski, Saso   +14 more
core   +1 more source

Influence of osteocytes in the in vitro and in vivo β-tricalcium phosphate-stimulated osteogenesis [PDF]

, 2014
Osteocytes, known to act as the main regulators of bone homeostasis, have become a major focus in the field of bone research. Bioactive ceramics have been widely used for bone regeneration.
Yuen, Jones, Klein, Travis, Chen, Zetao, Crawford, Ross, Wu, Chengtie, Xiao, Yin   +5 more
core   +1 more source

Effect of TNF-α-Induced Sclerostin on Osteocytes during Orthodontic Tooth Movement

Journal of Immunology Research, 2019
Osteocytes are abundant cells in bone, which contribute to bone maintenance. Osteocytes express receptor activator of nuclear factor kappa-B ligand (RANKL) and regulate osteoclast formation.
Fumitoshi Ohori, Hideki Kitaura, Aseel Marahleh, Akiko Kishikawa, Saika Ogawa, Jiawei Qi, Wei-Ren Shen, Takahiro Noguchi, Yasuhiko Nara, Itaru Mizoguchi   +9 more
doaj   +1 more source

Inhibition of Cdk5 Ameliorates Skeletal Bone Loss in Glucocorticoid-Treated Mice

Biomedicines, 2022
Glucocorticoids (GCs) are widely used to treat inflammatory diseases. However, their long-term use leads to glucocorticoid-induced osteoporosis, increasing morbidity and mortality. Both anabolic and anti-resorptive drugs are used to counteract GC-induced
Benjamin Thilo Krüger, Lena Steppe, Sabine Vettorazzi, Melanie Haffner-Luntzer, Sooyeon Lee, Ann-Kristin Dorn, Anita Ignatius, Jan Tuckermann, Mubashir Ahmad   +8 more
doaj   +1 more source

TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation

Frontiers in Immunology, 2019
Osteoimmunology peeks into the interaction of bone and the immune system, which has largely proved to be a multiplex reaction. Osteocytes have been shown to regulate bone resorption through the expression of RANKL in physiologic and pathologic conditions.
Aseel Marahleh, Hideki Kitaura, Fumitoshi Ohori, Akiko Kishikawa, Saika Ogawa, Wei-Ren Shen, Jiawei Qi, Takahiro Noguchi, Yasuhiko Nara, Itaru Mizoguchi   +9 more
doaj   +1 more source

A Novel 3D Osteoblast and Osteocyte Model Revealing Changes in Mineralization and Pro-osteoclastogenic Paracrine Signaling During Estrogen Deficiency

Frontiers in Bioengineering and Biotechnology, 2020
Recent in vitro studies have revealed that the mechanobiological responses of osteoblasts and osteocytes are fundamentally impaired during estrogen deficiency.
Syeda Masooma Naqvi, Juan Alberto Panadero Pérez, Vatsal Kumar, Anneke S. K. Verbruggen, Laoise M. McNamara   +4 more
doaj   +1 more source

Osteocytes Serve as a Reservoir for Intracellular Persisting Staphylococcus aureus Due to the Lack of Defense Mechanisms

Frontiers in Microbiology, 2022
Chronic staphylococcal osteomyelitis can persist for long time periods causing bone destruction. The ability of Staphylococcus aureus to develop chronic infections is linked to its capacity to invade and replicate within osteoblasts and osteocytes and to
Marina Garcia-Moreno, Paul M. Jordan, Kerstin Günther, Therese Dau, Christian Fritzsch, Monika Vermes, Astrid Schoppa, Anita Ignatius, Britt Wildemann, Oliver Werz, Bettina Löffler, Lorena Tuchscherr   +11 more
doaj   +1 more source

MT1-MMP modulates the mechanosensitivity of osteocytes [PDF]

, 2012
Membrane-type matrix metalloproteinase-1 (MT1-MMP) is expressed by mechanosensitive osteocytes and affects bone mass. The extracellular domain of MT1-MMP is connected to extracellular matrix, while its intracellular domain is a strong modulator of cell ...
Bakker, A.D., Veldkamp, J.B.B., Everts, V., Kulkarni, R.N., Klein-Nulend, J., Chae, T.D., Gruber, E.V.   +6 more
core   +1 more source

Targeting osteocytes vs osteoblasts [PDF]

, 2023
Although osteoblasts and osteocytes are descended from the same lineage, they each have unique and essential roles in bone. Targeting gene deletion to osteoblasts and osteocytes using the Cre/loxP system has greatly increased our current understanding of
M. Prideaux, Y. Kitase, Kitase, Y., Prideaux, M.   +3 more
core   +2 more sources