Results 1 to 10 of about 13,466 (213)

Adipocytic sclerostin loop3-LRP4 interaction required by sclerostin to impair whole-body lipid and glucose metabolism [PDF]

Nature Communications
Sclerostin, which has three loops, inhibits bone formation and impairs whole-body lipid and glucose metabolism. The marketed therapeutic sclerostin antibody for postmenopausal osteoporosis (POP) mainly targeting loop2 promotes bone formation and improves
Hewen Jiang, Xiaohui Tao, Sifan Yu, Yihao Zhang, Yuan Ma, Nanxi Li, Shenghang Wang, Ning Zhang, Xin Yang, Shijian Ding, Chuanxin Zhong, Haitian Li, Zhanghao Li, Xiaoxin Wen, Huarui Zhang, Zefeng Chen, Meiheng Sun, Hang Luo, Meishen Ren, Chongguang Lei, Yuanyuan Yu, Jin Liu, Zongkang Zhang, Aiping Lyu, Hui Sheng, Dijie Li, Luyao Wang, Ge Zhang, Bao-Ting Zhang   +28 more
doaj   +3 more sources

Sclerostin promotes human dental pulp cells senescence [PDF]

PeerJ, 2018
Background Senescence-related impairment of proliferation and differentiation limits the use of dental pulp cells for tissue regeneration. Deletion of sclerostin improves the dentinogenesis regeneration, while its role in dental pulp senescence is ...
Yanjing Ou, Yi Zhou, Shanshan Liang, Yining Wang   +3 more
doaj   +4 more sources

Osteoblastic sclerostin loop3-LRP4 interaction required by sclerostin to inhibit bone formation [PDF]

Bone Research
Sclerostin negatively regulates bone formation. The marketed antibody against sclerostin loop2 promoted bone formation but may have caused severe cardiovascular events in clinical use.
Luyao Wang, Xiaohui Tao, Hewen Jiang, Shijian Ding, Ning Zhang, Xin Yang, Shenghang Wang, Yihao Zhang, Nanxi Li, Haitian Li, Zhanghao Li, Xiaoxin Wen, Meiheng Sun, Chuanxin Zhong, Heiwa So, Jin Liu, Yuanyuan Yu, Hua Yue, Xianghang Luo, Péter Ferdinandy, Tao Zhang, Shu Zhang, Zhenlin Zhang, Aiping Lu, Baoting Zhang, Ge Zhang   +25 more
doaj   +2 more sources

Blocking interaction of sclerostin loop3 with osteoblastic LRP4 counteracts bone loss without increasing arterial stiffness during mechanical unloading [PDF]

Journal of Orthopaedic Translation
Background: Mechanical unloading leads to bone loss and cardiovascular deconditioning, accompanied by elevated sclerostin expression. Genetic Sost knockout or pharmacologic sclerostin antibody treatment was reported to counteract bone loss during ...
Luyao Wang, Ning Zhang, Hewen Jiang, Xiaohui Tao, Yuan Ma, Zebing Hu, Chuanxin Zhong, Xin Yang, Sifan Yu, Huarui Zhang, Jin Liu, Yuanyuan Yu, Fangwu Liu, Zefeng Chen, Hang Luo, Shijian Ding, Yihao Zhang, Meiheng Sun, Shiqing Zhang, Péter Ferdinandy, Rongjun Yu, Tao Zhang, Aiping Lu, Ling Qin, Shu Zhang, Baoting Zhang, Ge Zhang   +26 more
doaj   +2 more sources

B4GALNT3 regulates glycosylation of sclerostin and bone massResearch in context [PDF]

EBioMedicine, 2023
Summary: Background: Global sclerostin inhibition reduces fracture risk efficiently but has been associated with cardiovascular side effects. The strongest genetic signal for circulating sclerostin is in the B4GALNT3 gene region, but the causal gene is ...
Sofia Movérare-Skrtic, Jakob Voelkl, Karin H. Nilsson, Maria Nethander, Trang Thi Doan Luong, Ioana Alesutan, Lei Li, Jianyao Wu, Karin Horkeby, Marie K. Lagerquist, Antti Koskela, Juha Tuukkanen, Jon H. Tobias, Ulf H. Lerner, Petra Henning, Claes Ohlsson   +15 more
doaj   +2 more sources

Serum Bone-, Muscle- and Fat- Derived Factors Sclerostin, Irisin and Leptin Show Different Correlations With Body Composition and Bone Mineral Density in Chinese Men With Obesity: A Cross-Sectional Study. [PDF]

Diabetes Metab Res Rev
ABSTRACT Aims This study aimed to explore the interactions among sclerostin, irisin and leptin, as well as their associations with body composition and bone metabolism in Chinese men with obesity. Materials and Methods This study included 26 men with normal weight and 78 men with obesity.
Chen X, Shen S, Zou M, Zhang Z, Tong N, Li J.   +5 more
europepmc   +2 more sources

Intracellular sclerostin promotes tumor progression and metastasis as a potential therapeutic target in triple-negative breast cancer [PDF]

Cell Reports Medicine
Summary: Triple-negative breast cancer (TNBC) urgently requires promising therapeutic targets. This study identifies sclerostin, an osteocyte-derived secretory protein traditionally linked to bone homeostasis, as an unexpected intracellular oncogenic ...
Meiheng Sun, Hang Luo, Shuangying Qiao, Zefeng Chen, Hewen Jiang, Xin Yang, Shijian Ding, Yuan Tian, Yingchao Wu, Peng Wu, Yihao Zhang, Xiaohui Tao, Yuanyuan Yu, Luyao Wang, Jianhui Tian, Wei Kang, Daqing Ma, Yixin He, Aiping Lu, Feng-Lai Yuan, Yuan Ma, Fangfei Li, Bao-Ting Zhang, Qianjun Chen, Ge Zhang   +24 more
doaj   +2 more sources

Cardiovascular Safety of Anti-Sclerostin Therapy in Chronic Kidney Disease

Metabolites, 2021
The significance of sclerostin for bone and cardiovascular health in patients with chronic kidney disease (CKD) is complex and incompletely understood. Experimental evidence suggests that anti-sclerostin therapy shows diminished efficacy on bone in the ...
Daniel Cejka
doaj   +2 more sources

Association Between Sclerostin and Sarcopenia-Related Functional Decline in Older Women [PDF]

Diagnostics
Background: Sclerostin, an osteocyte-derived glycoprotein, plays a key role in bone metabolism by inhibiting the Wnt/β-catenin signaling pathway. While it is a recognized therapeutic target in osteoporosis, its relationship with sarcopenia remains ...
Dong Gyu Lee, Jong Ho Lee, Eunjung Kong
doaj   +2 more sources

The Association of Urinary Sclerostin and Renal Magnesium Handling in Type 2 Diabetic Patients with Chronic Kidney Disease

Kidney & Blood Pressure Research, 2021
Introduction: Sclerostin could enhance renal excretion of calcium (Ca) and phosphate (P). The association between sclerostin and magnesium (Mg) has not yet discovered.
Ching-Fang Wu, Hung-Hsiang Liou, Chin-Chi Kuo, Ming-Hsien Tsai, Min-Yu Chang, Yi-Che Lee, Tsun-Mei Lin, Shih-Yuan Hung   +7 more
doaj   +1 more source