Results 1 to 10 of about 11,659 (170)

Sclerostin and Cardiovascular Disease

Current Osteoporosis Reports, 2023
Purpose of ReviewThe role of wnt signalling in atherogenesis raises the possibility that the wnt inhibitor, sclerostin, provides a natural defence to this process, and that anti-sclerostin antibodies might increase the risk of atherosclerosis and ...
Tobias, Jonathan H, Jonathan H. Tobias
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Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling [PDF]

PLoS ONE, 2013
Sclerosteosis is a rare high bone mass disease that is caused by inactivating mutations in the SOST gene. Its gene product, Sclerostin, is a key negative regulator of bone formation and might therefore serve as a target for the anabolic treatment of ...
Stella E Weidauer, Juan Zhang, Stella E. Weidauer (408003), Mueller, T.D., Verena Boschert, Kasteren, P.B. van, Thomas D. Mueller (240937), Boschert, Verena, ten Dijke, Peter, Eva-Maria Muth (408005), Weidauer, Stella E., Puck B. van Kasteren (408008), Zhang, Juan, Puck B. Van Kasteren, Juan Zhang (48597), Knappik, Achim, Eva-Maria Muth, Peter ten Dijke, Gorter, D.J.J. de, Muth, Eva-Maria, Thomas D Mueller, Weidauer, S.E., Muth, E.M., Müller, Thomas D., Zhang, J., Achim Knappik (408006), de Gorter, David J. J., Puck B van Kasteren, Dinther, M. van, Christian Frisch, van Dinther, Maarten, Thomas D. Mueller, Christian Frisch (237601), Dijke, P. ten, Frisch, C., Maarten van Dinther, David J. J. de Gorter (408007), Maarten van Dinther (408002), Boschert, V., Verena Boschert (408004), Frisch, Christian, Achim Knappik, David J J de Gorter, Stella E. Weidauer, van Kasteren, Puck B., Knappik, A., David J. J. De Gorter, Peter ten Dijke (82259)   +47 more
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Sclerostin and Vascular Pathophysiology [PDF]

International Journal of Molecular Sciences, 2020
There is cumulating evidence for a contribution of Wnt signaling pathways in multiple processes involved in atherosclerosis and vascular aging. Wnt signaling plays a role in endothelial dysfunction, in the proliferation and migration of vascular smooth ...
Catalano, Corica, Morabito, Bellone
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Sclerostin [PDF]

Journal of Osteoporosis, 2010
The striking clinical benefits of intermittent parathyroid hormone in osteoporosis have begun a new era of skeletal anabolic agents.
Stuart L. Silverman
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Dental and periodontal phenotype in sclerostin knockout mice [PDF]

International Journal of Oral Science, 2014
Sclerostin is a Wnt signalling antagonist that controls bone metabolism. Sclerostin is expressed by osteocytes and cementocytes; however, its role in the formation of dental structures remains unclear.
Ulrike Kuchler, Uwe Y Schwarze, Toni Dobšák   +2 more
exaly   +2 more sources

Sclerostin levels during growth in children

Osteoporosis International, 2011
Serum sclerostin levels are associated with cortical porosity, suggesting that changes in sclerostin production during growth may play a role in defining cortical structure.Introduction: Sclerostin, produced by osteocytes, is a potent inhibitor of Wnt ...
Elizabeth J Atkinson, Sundeep Khosla, Khosla S   +2 more
exaly   +2 more sources

Role of Sclerostin in Cardiovascular Disease

Arteriosclerosis, Thrombosis, and Vascular Biology, 2022
Sclerostin is most recognized for its role in controlling bone formation but is also expressed in the heart, aorta, coronary, and peripheral arteries. This review summarizes research on sclerostin’s role in cardiovascular disease.
Golledge, Jonathan, Thanigaimani, Shivshankar   +1 more
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The Role of Sclerostin in Bone Diseases [PDF]

Journal of Clinical Medicine, 2022
Sclerostin has been identified as an important regulator of bone homeostasis through inhibition of the canonical Wnt-signaling pathway, and it is involved in the pathogenesis of many different skeletal diseases.
Pneumaticos, Spyros G., Vlachos, Christos, Vasiliadis, Elias S., Evangelopoulos, Dimitrios-Stergios, Benetos, Ioannis S., Kaspiris, Angelos   +5 more
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Sclerostin: From Molecule to Clinical Biomarker

International Journal of Molecular Sciences, 2022
Sclerostin, a glycoprotein encoded by the SOST gene, is mainly produced by mature osteocytes and is a critical regulator of bone formation through its inhibitory effect on Wnt signaling.
Diana Atanasova, Atanasova, Diana,, Filip Landgren, Magnusson, Per, Omran, Ahmed,, Per Magnusson, Omran, Ahmed, Landgren, Filip,, Magnusson, Per,, Atanasova, Diana, Landgren, Filip, Ahmed Omran   +11 more
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Changes in bone sclerostin levels in mice after ovariectomy vary independently of changes in serum sclerostin levels

Journal of Bone and Mineral Research, 2013
We examined the effects that ovariectomy had on sclerostin mRNA and protein levels in the bones of 8-week-old mice that were either sham-operated (SHAM) or ovariectomized (OVX) and then euthanized 3 or 6 weeks later.
Sandra Jastrzebski, Marina Stolina, Faryal Mírzá   +2 more
exaly   +2 more sources