Results 11 to 20 of about 11,659 (170)

Role of Sclerostin in Cardiovascular System

International Journal of Molecular Sciences
Sclerostin, encoded by the SOST gene, is a novel bone anabolic target for bone diseases. Humanized anti-sclerostin antibody, romosozumab, was approved for treatment of postmenopausal osteoporosis by the US Food and Drug Administration (FDA), but with a ...
Hewen Jiang, Jin Liu, Yuan Ma, Luyao Wang, Xiaofei Li, Ge Zhang, Xin Yang, Ning Zhang, Baoting Zhang, Sifan Yu, Xiaohui Tao, Yuanyuan Yu   +11 more
core   +3 more sources

Sclerostin and occlusion: A brief review

Journal of Indian Society of Periodontology, 2015
In its pursuit of understanding the wonders of human body, mankind has stumbled upon yet another discovery which not only is a key to chest of unanswered queries but also opens a plethora of new possibilities. Till recently the osteocytes were considered
Afshan Bey, Narinder Dev Gupta, Pankaj Bansal, Pritma Singh   +3 more
core   +4 more sources

Sclerostin : another vascular calcification inhibitor? [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2013
: Context: Sclerostin, a Wnt antagonist produced by osteocytes, regulates osteoblast activity and is a well-established key player in bone turnover. Recent data indicate that the Wnt pathway may also be involved in vascular calcification.
Meijers, Bj\uf6rn, d' Haese, Patrick C., Claes, Kathleen J., Viaene, Liesbeth, Evenepoel, Pieter, Heye, Sam   +5 more
core   +4 more sources

In silico identification of sclerostin inhibitors

Molecular Diversity
Wnt/beta-catenin signaling pathway plays a major role in the regulation of bone homeostasis. Sclerostin exhibits a high-affinity binding to the Wnt co-receptors LRP5/6 and therefore acts as an extracellular inhibitor of canonical Wnt signaling ...
Dinçel, Aylin Sepici, Erkoç, Şakir, Dinçel, AYLİN, Ergünol, Erdal, Şimşek, Yusuf, Uludamar, Altay, Baran, Sahra Setenay   +6 more
core   +4 more sources

Inhibitors of sclerostin [PDF]

Current Opinion in Rheumatology, 2014
Recent data suggest that inhibitors of sclerostin, an osteocyte-produced Wnt signaling pathway antagonist, can stimulate bone formation. This review provides rationale and summarizes recent evidence supporting this novel approach to skeletal anabolism.Data from numerous preclinical models in rodents and monkeys consistently demonstrate that ...
Matthew T, Drake, Joshua N, Farr
openaire   +2 more sources

Endocrine functions of sclerostin

Current Opinion in Endocrine and Metabolic Research, 2023
Sclerostin, the product of the SOST gene has primarily been studied for its profound impact on bone mass. By interacting with LRP5 and LRP6, the glycoprotein suppresses the propagation of Wnt signals to β-catenin and thereby suppresses new bone formation.
openaire   +2 more sources

Cardiovascular Safety and Sclerostin Inhibition

The Journal of Clinical Endocrinology & Metabolism, 2021
Abstract Sclerostin, which is primarily produced by the osteocytes, inhibits the canonical Wnt pathway and thereby the osteoblasts and stimulates RANKL release by the osteocytes and thereby osteoclast recruitment. Inhibition of sclerostin therefore causes stimulation of bone formation and inhibition of resorption.
Bente Lomholt Langdahl, Lorenz Christian Hofbauer, John Colin Forfar   +2 more
openaire   +3 more sources

Osteoblastic sclerostin loop3-LRP4 interaction required by sclerostin to inhibit bone formation. [PDF]

Bone Res
Abstract Sclerostin negatively regulates bone formation. The marketed antibody against sclerostin loop2 promoted bone formation but may have caused severe cardiovascular events in clinical use. In our published studies, sclerostin loop3 was found to be involved in inhibitory effects of sclerostin on bone formation,
Wang L, Tao X, Jiang H, Ding S, Zhang N, Yang X, Wang S, Zhang Y, Li N, Li H, Li Z, Wen X, Sun M, Zhong C, So H, Liu J, Yu Y, Yue H, Luo X, Ferdinandy P, Zhang T, Zhang S, Zhang Z, Lu A, Zhang B, Zhang G.   +25 more
europepmc   +2 more sources

Sclerostin–erbB-3 interactions: Modulation of erbB-3 activity by sclerostin [PDF]

Biochemical and Biophysical Research Communications, 2010
To gain insights into the mechanism of action of sclerostin, a protein that regulates bone mass, we performed yeast two-hybrid analyses using human SOST (sclerostin) cDNA cloned into pGBKT7 DNA-binding domain vector as a bait, and a normalized, high-complexity, universal cDNA library in a GAL4 activating domain vector.
Theodore A, Craig, Rajiv, Kumar
openaire   +2 more sources

The Effects of Sclerostin on the Immune System [PDF]

Current Osteoporosis Reports, 2020
We reviewed recent progress on the role of sclerostin (SOST) and its effects on the immune system in order to summarize the current state of knowledge in osteoimmunology, in regard to hematopoiesis, lymphopoiesis, and inflammation.Changes in sclerostin levels affect distinct niches within the bone marrow that support hematopoietic stem cells and B cell
Cristine Donham, Jennifer O. Manilay
openaire   +4 more sources