Results 1 to 10 of about 11,099 (162)

Role of SOST in Response to Mechanical Stimulation in Bone and Extraosseous Organs

Biomolecules
Sclerostin (SOST) is a specific osteocyte protein. During the differentiation and proliferation of osteoblasts and osteoclasts, the high expression of SOST can inhibit bone formation and contribute to osteoporosis and the bone metastasis of malignant ...
Lingli Zhang
exaly   +4 more sources

HIF-1α inhibits Wnt signaling pathway by activating Sost expression in osteoblasts. [PDF]

PLoS ONE, 2013
The nature of the cellular and molecular mechanisms for the transition of avascular cartilage replacement with bone during endochondral ossification remains poorly understood. One of the driving forces is hypoxia.
Dafu Chen, Yang Li, Zhiyu Zhou, Chengai Wu, Yonggang Xing, Xuenong Zou, Wei Tian, Chi Zhang   +7 more
doaj   +2 more sources

Proxied therapeutic inhibition on sclerostin and atrial fibrillation risk [PDF]

Communications Medicine
Background Pharmacological inhibition of sclerostin (SOST) is clinically applied to treat osteoporosis. However, large-scale randomized controlled trials have reported conflicting findings regarding the cardiovascular effects of SOST inhibition.
Yu Qian, Peng-Lin Guan, Jingyan Hu, Ming-Yu Han, Yi-Hu Fang, Wei-Lin Wang, Saber Khederzadeh, Yun-Piao Hou, Mo-Chang Qiu, Jian-Hua Gao, Cheng-Da Yuan, Fei Huang, David Karasik, Ching-Lung Cheung, Liu Yang, Yong Wang, Chao Zheng, Lin Bo, Hou-Feng Zheng   +18 more
doaj   +2 more sources

Metformin attenuates diabetic osteoporosis via the miR-21 mediated Mef2c/Sost pathway [PDF]

Frontiers in Endocrinology
ObjectiveObjectiveThis study aimed to explore the role of the miR-21/Mef2c/Sost pathway in the pathogenesis of diabetic osteoporosis (DOP) and to investigate whether metformin ameliorates DOP by regulating this signaling pathway.MethodsWe compared bone ...
Le Liu, Jie Xu, Hui Zheng, Xiao-chen Li, Zhong-ai Gao, Cheng Meng, Congqing Pan, Ju-hong Yang, Bao-cheng Chang   +8 more
doaj   +2 more sources

ESWT attenuates compressive stress-induced cartilaginous endplate degeneration via modulation of the SOST/Wnt/β-catenin signaling pathway [PDF]

Frontiers in Bioengineering and Biotechnology
IntroductionCartilaginous endplate (CEP) degeneration is a critical contributor to intervertebral disc degeneration (IVDD) and is frequently induced by sustained compressive stress.
Pan Xiang, Pan Xiang, Junjun Hou, Junjun Hou, Chao Yang, Chao Yang, Ting Liang, Ting Liang, Wenbin Cai, Wenbin Cai, Fanlei Yang, Fanlei Yang, Jing Yang, Hao Xu, Hao Xu, Zongping Luo, Zongping Luo, Yanjun Che, Yanjun Che, Yanjun Che   +19 more
doaj   +2 more sources

Sost deficiency leads to greater bone vascular porosity, but similar osteocyte lacunar properties with increasing age [PDF]

Bone Reports
Sclerostin neutralizing antibody is an approved anabolic drug used to increase bone mass. Numerous preclinical studies examined bone mass and microstructural changes in mice receiving sclerostin neutralizing antibodies or mice lacking sclerostin, such as
Taylor deVet, Anthony Helou, Sara Checa, Alexander Rack, Ina Kramer, Fabian Wilde, Paul Zaslansky, Bettina M. Willie   +7 more
doaj   +2 more sources

lncRNA MEG3 Suppresses the Progression of Ankylosis Spondylitis by Regulating the Let-7i/SOST Axis

Frontiers in Molecular Biosciences, 2020
Ankylosis spondylitis (AS) is a disease mainly characterized by sacroiliac joint and spinal attachment point inflammation. Long non-coding RNA (lncRNA) plays a key role in the progression of many diseases.
Junjie Ma, Xiaohua Zhang, Hongxing Zhang, Hailong Chen   +3 more
exaly   +3 more sources

Sost Deficiency does not Alter Bone’s Lacunar or Vascular Porosity in Mice

Frontiers in Materials, 2017
SCLEROSTIN (Sost) is expressed predominantly in osteocytes acting as a negative regulator of bone formation. In humans, mutations in the SOST gene lead to skeletal overgrowth and increased bone mineral density, suggesting that SCLEROSTIN is a key ...
Claire Clarkin, Behzad Javaheri, Andrew Pitsillides   +2 more
exaly   +3 more sources

In silico design of novel precision vaccine targeting sclerostin epitopes for osteoporosis prevention and treatment [PDF]

Frontiers in Immunology
BackgroundOsteoporosis has become an increasingly pressing global public health challenge. Monoclonal antibody romosozumab (ROMO), which targets sclerostin (SOST), a critical inhibitor of bone formation, demonstrates considerable therapeutic efficacy ...
Jianzhou Luo, Tailin Wu, Tailin Wu, Bin Guan, Lin Li, Zili Yang, Huiren Tao   +6 more
doaj   +2 more sources

In vitro and in vivo Repair Effects of the NCF-Col-NHA Aerogel Scaffold Loaded With SOST Monoclonal Antibody and SDF-1 in Steroid-Induced Osteonecrosis

Frontiers in Bioengineering and Biotechnology, 2022
In the current study, we synthesized nanocellulose (NCF)-collagen (Col)-nano hydroxyapatite (NHA) organic-inorganic hybrid aerogels loaded with stromal cell derived factor-1 (SDF-1) and sclerostin monoclonal antibody (SOST McAb) and investigated their ...
Bing Xu, Bing Xu, Zeyu Luo, Duan Wang, Zeyu Huang, Zongke Zhou, Haoyang Wang   +6 more
doaj   +1 more source