Results 1 to 10 of about 10,314 (209)

Sost Deficiency does not Alter Bone’s Lacunar or Vascular Porosity in Mice [PDF]

Frontiers in Materials, 2017
SCLEROSTIN (Sost) is expressed predominantly in osteocytes acting as a negative regulator of bone formation. In humans, mutations in the SOST gene lead to skeletal overgrowth and increased bone mineral density, suggesting that SCLEROSTIN is a key ...
Claire Clarkin, Behzad Javaheri, Andrew Pitsillides   +2 more
exaly   +13 more sources

HIF-1α inhibits Wnt signaling pathway by activating Sost expression in osteoblasts. [PDF]

PLoS ONE, 2013
The nature of the cellular and molecular mechanisms for the transition of avascular cartilage replacement with bone during endochondral ossification remains poorly understood. One of the driving forces is hypoxia.
Dafu Chen, Yang Li, Zhiyu Zhou, Chengai Wu, Yonggang Xing, Xuenong Zou, Wei Tian, Chi Zhang   +7 more
doaj   +3 more sources

Metformin attenuates diabetic osteoporosis via the miR-21 mediated Mef2c/Sost pathway [PDF]

Frontiers in Endocrinology
ObjectiveObjectiveThis study aimed to explore the role of the miR-21/Mef2c/Sost pathway in the pathogenesis of diabetic osteoporosis (DOP) and to investigate whether metformin ameliorates DOP by regulating this signaling pathway.MethodsWe compared bone ...
Le Liu, Jie Xu, Hui Zheng, Xiao-chen Li, Zhong-ai Gao, Cheng Meng, Congqing Pan, Ju-hong Yang, Bao-cheng Chang   +8 more
doaj   +2 more sources

Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo [PDF]

Molecular Therapy: Nucleic Acids, 2016
Sclerostin is a protein secreted by osteocytes that is encoded by the SOST gene; it decreases bone formation by reducing osteoblast differentiation through inhibition of the Wnt signaling pathway.
Genc Basha, Mina Ordobadi, Wilder R Scott, Andrew Cottle, Yan Liu, Haitang Wang, Pieter R Cullis   +6 more
doaj   +2 more sources

In silico design of novel precision vaccine targeting sclerostin epitopes for osteoporosis prevention and treatment [PDF]

Frontiers in Immunology
BackgroundOsteoporosis has become an increasingly pressing global public health challenge. Monoclonal antibody romosozumab (ROMO), which targets sclerostin (SOST), a critical inhibitor of bone formation, demonstrates considerable therapeutic efficacy ...
Jianzhou Luo, Tailin Wu, Tailin Wu, Bin Guan, Lin Li, Zili Yang, Huiren Tao   +6 more
doaj   +2 more sources

Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD [PDF]

Redox Biology
Sclerostin (Sost) functions as an inhibitor of the Wnt/β-catenin signaling pathway, which is known to promote kidney cell epithelial-to-mesenchymal transition (EMT), and fibrosis in chronic kidney disease (CKD).
Rang-yue Han, Rui-zhi Tan, Ling-hui Xu, Jing-yi Lin, Tong Li, Hong-wei Su, Ping Li, Peng Liu, Hui-yao Lan, Li Wang   +9 more
doaj   +2 more sources

Sclerostin Suppression Facilitates Uveal Melanoma Progression Through Activating Wnt/β-Catenin Signaling Via Binding to Membrane Receptors LRP5/LRP6

Frontiers in Oncology, 2022
ObjectiveUveal melanoma (UM) is the most frequent primary eye cancer in adults with a 50% mortality rate. Characterizing the fundamental signaling pathways that drive UM is of importance for the development of targeted therapy.
Hanqing Wang, Hanqing Wang, Sidi Zhao, Yang Liu, Fengyuan Sun, Fengyuan Sun, Xiaoming Huang, Xiaoming Huang, Tong Wu, Tong Wu   +9 more
doaj   +1 more source

In vitro and in vivo Repair Effects of the NCF-Col-NHA Aerogel Scaffold Loaded With SOST Monoclonal Antibody and SDF-1 in Steroid-Induced Osteonecrosis

Frontiers in Bioengineering and Biotechnology, 2022
In the current study, we synthesized nanocellulose (NCF)-collagen (Col)-nano hydroxyapatite (NHA) organic-inorganic hybrid aerogels loaded with stromal cell derived factor-1 (SDF-1) and sclerostin monoclonal antibody (SOST McAb) and investigated their ...
Bing Xu, Bing Xu, Zeyu Luo, Duan Wang, Zeyu Huang, Zongke Zhou, Haoyang Wang   +6 more
doaj   +1 more source

Targeting SOST using a small-molecule compound retards breast cancer bone metastasis

Molecular Cancer, 2022
Background Breast cancer metastasis to the bone can be exacerbated by osteoporosis, is associated with poor long-term survival, and has limited therapeutic options.
Lisha Sun, Yixiao Zhang, Guanglei Chen, Yaoting Ji, Qingtian Ma, Xinbo Qiao, Sijin Wu, Lin Zhou, Jiawen Bu, Xudong Zhu, Xiaoying Zhang, Xiaofan Jiang, Chao Liu, Xinnan Li, Yang Liu, Yongliang Yang, Caigang Liu   +16 more
doaj   +1 more source

Effect of sclerostin inactivation in a mouse model of severe dominant osteogenesis imperfecta

Scientific Reports, 2023
Osteogenesis imperfecta (OI) is a rare bone disease that is associated with fractures and low bone mass. Sclerostin inhibition is being evaluated as a potential approach to increase bone mass in OI.
Juliana Marulanda, Josephine T. Tauer, Iris Boraschi-Diaz, Ghalib Bardai, Frank Rauch   +4 more
doaj   +1 more source