Results 41 to 50 of about 10,314 (209)
All-trans Retinoic Acid and Beta-Carotene Increase Sclerostin Production in C2C12 Myotubes
Biomedicines, 2023 Sclerostin is a protein secreted by osteocytes whose encoding gene SOST is regulated by mechanical stimuli, cytokines, and all-trans retinoic acid (ATRA) and mediates antianabolic effects on bone formation as an inhibitor of the canonical Wnt/β-catenin ...
Franz Ewendt +3 more
doaj +1 more source
Nitric oxide is involved in the down-regulation of sost expression induced by mechanical loading [PDF]
, 2014 Mechanical stimulation reduces sclerostin expression in rodents. However, few data are available about the effect of physical stimuli in human systems. Recently we observed that the demethylating agent AzadC induces SOST expression in bone cells.
Riancho, J.A. +2 more
core +1 more source
Revista de Osteoporosis y Metabolismo Mineral, 2020 Introducción: Varios estudios de barrido genómico (GWAS) y otros focalizados en el gen de la esclerostina (SOST) han encontrado que algunos polimorfismos de SOST se asocian con la masa ósea y el riesgo de fracturas.
Del Real A +10 more
doaj +1 more source
SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor [PDF]
Journal of Biological Chemistry, 2005 Sclerosteosis is an autosomal recessive disease that is characterized by overgrowth of bone tissue and is linked to mutations in the gene encoding the secreted protein SOST. Sclerosteosis shares remarkable similarities with "high bone mass" diseases caused by "gain-of-function" mutations in the LRP5 gene, which encodes a coreceptor for Wnt signaling ...
Mikhail, Semënov, Keiko, Tamai, Xi, He
openaire +2 more sources
Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation [PDF]
, 2016 Sclerostin (Sost) is a negative regulator of bone formation that acts upon the Wnt signaling pathway. Sost is mechanically regulated at both mRNA and protein level such that loading represses and unloading enhances Sost expression, in osteocytes and in ...
Loots, Gabriela G. +11 more
core +1 more source
A Novel Mutation in SOST Gene Causes Sclerosteosis
Journal of the Endocrine Society, 2021 Abstract Background: Sclerostin is a SOST gene product that inhibits osteoblasts activity and prevents excessive bone formation by antagonizing Wnt signaling pathway. Sclerosteosis has been linked to the loss of function mutation in SOST gene.
Alyusuf, Ebtihal Y +2 more
openaire +1 more source
TIEG and estrogen modulate SOST expression in the murine skeleton [PDF]
Journal of Cellular Physiology, 2017 TIEG knockout (KO) mice exhibit a female‐specific osteopenic phenotype and altered expression of TIEG in humans is associated with osteoporosis. Gene expression profiling studies identified sclerostin as one of the most highly up‐regulated transcripts in the long bones of TIEG KO mice relative to WT littermates suggesting that TIEG may regulate SOST ...
Malayannan Subramaniam +4 more
openaire +2 more sources
messaletto (sost.), TLIO, Tesoro della lingua italiana delle Origini. [PDF]
, 2022 Elaborazione voce TLIO, messaletto (sost.)
Jessica Puliero
core
Anatomical similarity between the Sost‐knockout mouse and sclerosteosis in humans [PDF]
The Anatomical Record, 2019 AbstractSclerosteosis, a rare autosomal recessive genetic disorder caused by a mutation of the Sost gene, manifests in the facial skeleton by gigantism, facial distortion, mandibular prognathism, cranial nerve palsy, and, in extreme cases, compression of the medulla oblongata.
Uwe Y. Schwarze +3 more
openaire +3 more sources
gavettone (sost.), TLIO, Tesoro della lingua italiana delle Origini. [PDF]
, 2022 Elaborazione voce TLIO, gavettone (sost.)
Puliero Jessica
core