Results 31 to 40 of about 11,099 (162)

All-trans Retinoic Acid and Beta-Carotene Increase Sclerostin Production in C2C12 Myotubes

Biomedicines, 2023
Sclerostin is a protein secreted by osteocytes whose encoding gene SOST is regulated by mechanical stimuli, cytokines, and all-trans retinoic acid (ATRA) and mediates antianabolic effects on bone formation as an inhibitor of the canonical Wnt/β-catenin ...
Franz Ewendt, Anne Lehmann, Maximilian F. Wodak, Gabriele I. Stangl   +3 more
doaj   +1 more source

The Pacific Island Volcanology and Its Relation to the Groundwater Features Through Magmatic Signatures [PDF]

Sustainable Earth Trends
The Pacific Plate is one of the heaviest tectonic plates, hosting multiple Pacific Island countries. Geological research has long provided evidence of volcanic magmatic events, which have frequently caused subsurface activities.
Ronald Maharaj, Azekah Swamy, Shailesh Kumar Singh, Sandeep Panchal   +3 more
doaj   +1 more source

Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort. [PDF]

PLoS ONE, 2015
To investigate DKK-1 and SOST serum levels among patients with recent inflammatory back pain (IBP) fulfilling ASAS criteria for SpA and associated factors.The DESIR cohort is a prospective, multicenter French cohort of 708 patients with early IBP ...
Gaetane Nocturne, Stephan Pavy, Saida Boudaoud, Raphaèle Seror, Philippe Goupille, Philippe Chanson, Désirée van der Heijde, Floris van Gaalen, Francis Berenbaum, Xavier Mariette, Karine Briot, Antoine Feydy, Pascal Claudepierre, Philippe Dieudé, Joanne Nithitham, Kimberly E Taylor, Lindsey A Criswell, Maxime Dougados, Christian Roux, Corinne Miceli-Richard   +19 more
doaj   +1 more source

Calvarial Characterization of Dicer-Deficient under Sost Promotor Mouse Model

, 2023
This study aims to evaluate the roles of mature miRNAs in osteocytes of calvarial bones. The skulls of transgenic Dicer deficiency driven under Sost (Dicer/Sost KO) mice were compared to the age and sex-matched control mice (Dicer floxed and Sostcre). We
Youngjae Sung (15107353)
core   +1 more source

Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation [PDF]

, 2016
Sclerostin (Sost) is a negative regulator of bone formation that acts upon the Wnt signaling pathway. Sost is mechanically regulated at both mRNA and protein level such that loading represses and unloading enhances Sost expression, in osteocytes and in ...
Loots, Gabriela G., Genetos, Damian C., Genetos, Damian C, Murugesh, Deepa, Robling, Alexander G, Bullock, Whitney A, Foster, William H, Robling, Alexander G., Bullock, Whitney A., Foster, William H., Kang, Kyung Shin, Loots, Gabriela G   +11 more
core   +1 more source

SOST Gene Inhibits Osteogenesis from Adipose-Derived Mesenchymal Stem Cells by Inducing Th17 Cell Differentiation

Cellular Physiology and Biochemistry, 2018
Background/Aims: Postmenopausal osteoporosis is considered to be an autoimmune and inflammatory process, and IL-17 plays important roles in the loss of bone mass.
Li  You, Lin Chen, Ling Pan, Yongde Peng, Jinyu Chen   +4 more
doaj   +1 more source

Impacto funcional de polimorfismos del gen de la esclerostina sobre la metilación de ADN y la expresión génica

Revista de Osteoporosis y Metabolismo Mineral, 2020
Introducción: Varios estudios de barrido genómico (GWAS) y otros focalizados en el gen de la esclerostina (SOST) han encontrado que algunos polimorfismos de SOST se asocian con la masa ósea y el riesgo de fracturas.
Del Real A, Sañudo C, García-Ibarbia C, Santurtún A, Zarrabeitia MT, Pérez-Núñez MI, Laguna E, López-Delgado L, Fernández AF, Fraga MF, Riancho JA   +10 more
doaj   +1 more source

Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD

Redox Biology
Sclerostin (Sost) functions as an inhibitor of the Wnt/β-catenin signaling pathway, which is known to promote kidney cell epithelial-to-mesenchymal transition (EMT), and fibrosis in chronic kidney disease (CKD).
Rang-yue Han, Rui-zhi Tan, Ling-hui Xu, Jing-yi Lin, Tong Li, Hong-wei Su, Ping Li, Peng Liu, Hui-yao Lan, Li Wang   +9 more
doaj   +1 more source

Variations of SOST mRNA expression in human bone are associated with DNA polymorphism and DNA methylation in the SOST gene

, 2016
International audienceSOST encodes sclerostin, an inhibitor of bone formation that antagonizes canonical Wnt signaling. Variations of SOST expression have an impact on bone mineral density (BMD) and bone strength.
Ostertag, Agnes, Lhaneche, Leila, de Vernejoul, Marie-Christine, Harsløf, Torben, Zelenika, Diana, Domingues, Aline, Hannouche, Didier, Delepine, Marc, Jehan, Frédéric, Boland, Anne, Cohen-Solal, Martine, Hald, Jannie, Geoffroy, Valérie, Langdahl, Bente, Hald, Jannie D, Langdahl, Bente L   +15 more
core   +1 more source

Transcriptional control of Sost in bone [PDF]

, 2016
Sclerostin is an osteocyte derived negative regulator of bone formation. A highly specific expression pattern and the exclusive bone phenotype have made Sclerostin an attractive target for therapeutic intervention in treating metabolic bone diseases such
Loots, Gabriela G., Sebastian, Aimy
core   +1 more source