Results 31 to 40 of about 10,314 (209)

The Impact of the Extracellular Matrix Environment on Sost Expression by the MLO-Y4 Osteocyte Cell Line

Bioengineering, 2022
Bone is a dynamic organ that can adapt its structure to meet the demands of its biochemical and biophysical environment. Osteocytes form a sensory network throughout the tissue and orchestrate tissue adaptation via the release of soluble factors such as ...
Robert T. Brady, Fergal J. O’Brien, David A. Hoey   +2 more
doaj   +1 more source

Effect of HIF-1α on Sost promoter activity. [PDF]

, 2013
(A) HIF-1α activates the Sost promoter in a dose-dependent manner. HEK293 cells were transfected with a 1 kb Sost promoter-luciferase reporter gene without or with increasing amounts of an HIF-1α-expression plasmid as indicated.
Chi Zhang (9857), Yonggang Xing (291915), Zhiyu Zhou (291914), Yang Li (7082), Wei Tian (291921), Xuenong Zou (291919), Chengai Wu (420708), Dafu Chen (291913)   +7 more
core   +1 more source

TGFβ induces SOST expression through Smad3. [PDF]

, 2013
Treating UMR-106 cells with TGFβ1 (5 ng/ml) for 2, 8, or 24 h results in an increase in SOST mRNA, while inhibiting TGFβ signaling with SB431542 results in a decrease in SOST expression (A).
Tamara Alliston (265049), Jacqueline Nguyen (290539), Daniel Nguyen (290542), Simon Y. Tang (290540)   +3 more
core   +1 more source

Generation of Sost-Cre transgenic mice. [PDF]

, 2015
(A) Diagram of a portion of the Sost-Cre transgene construct used to generate Sost-Cre transgenic mice. UTR, untranslated region, IRES, internal ribosome entry site, GFP::Cre, fusion protein of GFP and the Cre recombinase.
Josh Campbell (798497), Stavros C. Manolagas (198084), Charles A. O’Brien (798500), Joseph J. Goellner (271077), Melda Onal (798496), Vladimir Dusevich (798498), Marilina Piemontese (798495), Lynda Bonewald (798499), Jinhu Xiong (798494)   +8 more
core   +1 more source

Identification of the minimal region in the promoter of Sost gene for HIF-1α activation. [PDF]

, 2013
(A) Schematic representation of the Sost deletion mutants. HRE: hypoxia response element. Sost-1 kb, Sost-540 bp, Sost-260 bp and Sost-106 bp Sost promoter reporter plasmids were constructed, using luciferase (LUC) as a reporter. (B) Deletion analysis of
Chi Zhang (9857), Yonggang Xing (291915), Zhiyu Zhou (291914), Yang Li (7082), Wei Tian (291921), Xuenong Zou (291919), Chengai Wu (420708), Dafu Chen (291913)   +7 more
core   +1 more source

SOST Gene Inhibits Osteogenesis from Adipose-Derived Mesenchymal Stem Cells by Inducing Th17 Cell Differentiation

Cellular Physiology and Biochemistry, 2018
Background/Aims: Postmenopausal osteoporosis is considered to be an autoimmune and inflammatory process, and IL-17 plays important roles in the loss of bone mass.
Li  You, Lin Chen, Ling Pan, Yongde Peng, Jinyu Chen   +4 more
doaj   +1 more source

Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort. [PDF]

PLoS ONE, 2015
To investigate DKK-1 and SOST serum levels among patients with recent inflammatory back pain (IBP) fulfilling ASAS criteria for SpA and associated factors.The DESIR cohort is a prospective, multicenter French cohort of 708 patients with early IBP ...
Gaetane Nocturne, Stephan Pavy, Saida Boudaoud, Raphaèle Seror, Philippe Goupille, Philippe Chanson, Désirée van der Heijde, Floris van Gaalen, Francis Berenbaum, Xavier Mariette, Karine Briot, Antoine Feydy, Pascal Claudepierre, Philippe Dieudé, Joanne Nithitham, Kimberly E Taylor, Lindsey A Criswell, Maxime Dougados, Christian Roux, Corinne Miceli-Richard   +19 more
doaj   +1 more source

Investigation of the Underlying Mechanism of Sclerosteosis Expression in Muscle Tissue in Multiple Myeloma with Sarcopenia

Journal of Inflammation Research, 2023
Jie Ren,1,* Jingzhou Wang,2,* Xingchen Yao,1 Yue Wu,1 Ming Shi,1 Xiangjun Shi,3 Xinru Du1 1Department of Orthopaedics, Beijing Chao-yang Hospital, Beijing, 100020, People’s Republic of China; 2Department of Orthopaedics, Beijing Daxing District ...
Ren J, Wang J, Yao X, Wu Y, Shi M, Shi X, Du X   +6 more
doaj  

The Pacific Island Volcanology and Its Relation to the Groundwater Features Through Magmatic Signatures [PDF]

Sustainable Earth Trends
The Pacific Plate is one of the heaviest tectonic plates, hosting multiple Pacific Island countries. Geological research has long provided evidence of volcanic magmatic events, which have frequently caused subsurface activities.
Ronald Maharaj, Azekah Swamy, Shailesh Kumar Singh, Sandeep Panchal   +3 more
doaj   +1 more source

lncRNA MEG3 Suppresses the Progression of Ankylosis Spondylitis by Regulating the Let-7i/SOST Axis

Frontiers in Molecular Biosciences, 2020
Ankylosis spondylitis (AS) is a disease mainly characterized by sacroiliac joint and spinal attachment point inflammation. Long non-coding RNA (lncRNA) plays a key role in the progression of many diseases.
Junjie Ma, Xiaohua Zhang, Hongxing Zhang, Hailong Chen   +3 more
doaj   +1 more source