Results 21 to 30 of about 10,314 (209)
Novel SOST gene mutation in a sclerosteosis patient and her parents [PDF]
Bone, 2013 Sclerosteosis (OMIM 269500) is a rare autosomal recessive condition characterized by increased bone density associated with syndactyly. It is linked to a genetic defect in the SOST gene coding for sclerostin. So far, six different loss-of-function mutations in SOST have been reported in patients with sclerosteosis.
Bhadada, Sanjay Kumar +7 more
openaire +4 more sources
Calvarial Characterization of Dicer-Deficient under Sost Promotor Mouse Model [PDF]
, 2023 This study aims to evaluate the roles of mature miRNAs in osteocytes of calvarial bones. The skulls of transgenic Dicer deficiency driven under Sost (Dicer/Sost KO) mice were compared to the age and sex-matched control mice (Dicer floxed and Sostcre). We
Youngjae Sung (15107353)
core +1 more source
SOST expression in zebrafish vertebra. [PDF]
, 2019 (a–f) An NS of zebrafish vertebra. (a) HE-stained section. The blue and yellow squares mark distal and proximal regions within the NS, respectively, shown at higher magnification in (b) and (c), respectively.
Shiri Kult (6288368) +9 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2020 Steroid-induced osteonecrosis of femoral head (SONFH) is a common and serious complication caused by long-term and/or excessive use of glucocorticoids (GCs). The decreased activity and abnormal differentiation of bone marrow mesenchymal stem cells (BMSCs)
Lizhi Han +7 more
doaj +1 more source
Immunohistochemical analysis of Sost after unloading. [PDF]
, 2012 Immunohistochemistry using anti-Sost antibody in tibial sections of control (A, B, E, F) and unloaded (C, D, G–J) groups in wild-type (A, C, E, G, I) and BCL2 transgenic (B, D, F, H, J) mice at 4 months of age. The boxed regions with asterisks in A–D are
Toshihisa Komori (154757) +7 more
core +1 more source
Methylation of the Sclerostin (SOST) Gene in Serum Free DNA: A New Bone Biomarker? [PDF]
, 2021 Introduction: Cell-free DNA (cfDNA) methylation is an important molecular biomarker, which provides information about the regulation of gene expression in the tissue of origin.
Real, Álvaro del +21 more
core +1 more source
Frontiers in Bioengineering and Biotechnology, 2019 Sclerostin (Sost) and dickkopf (Dkk)-1 are inhibitors of the Wnt signaling pathway that plays a role in regenerative processes. Hypoxia-based strategies are used for regenerative approaches, but the influence of hypoxia on Sost and Dkk-1 production in a ...
Klara Janjić +8 more
doaj +1 more source
Osteoprotegerin, sclerostin, and osteocalcin serum levels in thyroid disorder patients [PDF]
The Ukrainian Biochemical Journal, 2021 The maintenance of thyroid hormone homeostasis is essential in the regulation of skeletal system development, bone tissue mineralization and fracture risk prevention.
F. F. Rija, S. Z. Hussein, M. A. Abdalla
doaj +1 more source
, 2022 Supplemental Figures 1-4 Table 1 - Primers Table 2- Echo ...
Merryman, William, Joll, J. Ethan
openaire +1 more source
Genetics and Genomics of SOST: Functional Analysis of Variants and Genomic Regulation in Osteoblasts [PDF]
International Journal of Molecular Sciences, 2021 SOST encodes the sclerostin protein, which acts as a key extracellular inhibitor of the canonical Wnt pathway in bone, playing a crucial role in skeletal development and bone homeostasis. The objective of this work was to assess the functionality of two variants previously identified (the rare variant rs570754792 and the missense variant p.Val10Ile ...
Núria Martínez-Gil +7 more
openaire +4 more sources