Results 21 to 30 of about 11,099 (162)

Preaxial Polydactyly in Sost/Sostdc1 Double Knockouts [PDF]

, 2011
In the United States, {approx}5% are born with congenital birth defects due to abnormal function of cellular processes and interactions. Sclerosteosis, a rare autosomal recessive disease, causes hyperostosis of the axial and appendicular skeleton, and ...
Yee, C M, Collette, N M, N Collette, Loots, G G, G Loots, C Yee   +5 more
core   +1 more source

Targeting SOST using a small-molecule compound retards breast cancer bone metastasis

Molecular Cancer, 2022
Background Breast cancer metastasis to the bone can be exacerbated by osteoporosis, is associated with poor long-term survival, and has limited therapeutic options.
Lisha Sun, Yixiao Zhang, Guanglei Chen, Yaoting Ji, Qingtian Ma, Xinbo Qiao, Sijin Wu, Lin Zhou, Jiawen Bu, Xudong Zhu, Xiaoying Zhang, Xiaofan Jiang, Chao Liu, Xinnan Li, Yang Liu, Yongliang Yang, Caigang Liu   +16 more
doaj   +1 more source

Genetic evidence that SOST inhibits WNT signaling in the limb [PDF]

, 2010
SOST is a negative regulator of bone formation, and mutations in human SOST are responsible for sclerosteosis. In addition to high bone mass, sclerosteosis patients occasionally display hand defects, suggesting that SOST may function embryonically.
Genetos, Damian C., Loots, Gabriela G., Murugesh, Deepa, Collette, Nicole M., Harland, Richard M.   +4 more
core   +1 more source

The Influence of Pro-Inflammatory Factors on Sclerostin and Dickkopf-1 Production in Human Dental Pulp Cells Under Hypoxic Conditions

Frontiers in Bioengineering and Biotechnology, 2019
Sclerostin (Sost) and dickkopf (Dkk)-1 are inhibitors of the Wnt signaling pathway that plays a role in regenerative processes. Hypoxia-based strategies are used for regenerative approaches, but the influence of hypoxia on Sost and Dkk-1 production in a ...
Klara Janjić, Klara Janjić, Mohammad Samiei, Mohammad Samiei, Mohammad Samiei, Andreas Moritz, Andreas Moritz, Hermann Agis, Hermann Agis   +8 more
doaj   +1 more source

Knockdown of POSTN Inhibits Osteogenic Differentiation of Mesenchymal Stem Cells From Patients With Steroid-Induced Osteonecrosis

Frontiers in Cell and Developmental Biology, 2020
Steroid-induced osteonecrosis of femoral head (SONFH) is a common and serious complication caused by long-term and/or excessive use of glucocorticoids (GCs). The decreased activity and abnormal differentiation of bone marrow mesenchymal stem cells (BMSCs)
Lizhi Han, Song Gong, Ruoyu Wang, Shaokai Liu, Bo Wang, Guo Chen, Tianlun Gong, Weihua Xu   +7 more
doaj   +1 more source

Effect of sclerostin inactivation in a mouse model of severe dominant osteogenesis imperfecta

Scientific Reports, 2023
Osteogenesis imperfecta (OI) is a rare bone disease that is associated with fractures and low bone mass. Sclerostin inhibition is being evaluated as a potential approach to increase bone mass in OI.
Juliana Marulanda, Josephine T. Tauer, Iris Boraschi-Diaz, Ghalib Bardai, Frank Rauch   +4 more
doaj   +1 more source

Osteoprotegerin, sclerostin, and osteocalcin serum levels in thyroid disorder patients [PDF]

The Ukrainian Biochemical Journal, 2021
The maintenance of thyroid hormone homeostasis is essential in the regulation of skeletal system development, bone tissue mineralization and fracture risk prevention.
F. F. Rija, S. Z. Hussein, M. A. Abdalla
doaj   +1 more source

Methylation of the Sclerostin (SOST) Gene in Serum Free DNA: A New Bone Biomarker? [PDF]

, 2021
Introduction: Cell-free DNA (cfDNA) methylation is an important molecular biomarker, which provides information about the regulation of gene expression in the tissue of origin.
Real, Álvaro del, Pérez-Núñez, María I., Sañudo, Carolina, Laguna, Esther, Pérez-Campo, Flor Maria, Santurtún Zarrabeitia, Ana, Pérez Núñez, María Isabel, Laguna Bercero, Esther, García Ibarbia, María del Carmen, Riancho Moral, José Antonio, Fernández, Agustín F., Valero Díaz de Lamadrid, Carmen, García Unzueta, María Teresa, Santurtún, Ana, Garcia-Unzueta, M. Teresa, Pérez Campo, Flor María, Sañudo Campo, María Carolina, Fraga, Mario F., García-Ibarbia, Carmen, Riancho, José A., Del Real Bolt, Álvaro, Valero, M. Carmen   +21 more
core   +1 more source

The Impact of the Extracellular Matrix Environment on Sost Expression by the MLO-Y4 Osteocyte Cell Line

Bioengineering, 2022
Bone is a dynamic organ that can adapt its structure to meet the demands of its biochemical and biophysical environment. Osteocytes form a sensory network throughout the tissue and orchestrate tissue adaptation via the release of soluble factors such as ...
Robert T. Brady, Fergal J. O’Brien, David A. Hoey   +2 more
doaj   +1 more source

Investigation of the Underlying Mechanism of Sclerosteosis Expression in Muscle Tissue in Multiple Myeloma with Sarcopenia

Journal of Inflammation Research, 2023
Jie Ren,1,* Jingzhou Wang,2,* Xingchen Yao,1 Yue Wu,1 Ming Shi,1 Xiangjun Shi,3 Xinru Du1 1Department of Orthopaedics, Beijing Chao-yang Hospital, Beijing, 100020, People’s Republic of China; 2Department of Orthopaedics, Beijing Daxing District ...
Ren J, Wang J, Yao X, Wu Y, Shi M, Shi X, Du X   +6 more
doaj